Escherichia coli Pyometra Induces Transient Glomerular and Tubular Dysfunction in Dogs

Journal of Veterinary Internal Medicine

Volumn 24, Issue 6, 2010, Pages 1263-1270

  Maddens, B ^a   Daminet, S ^a   Smets, P ^a   Meyer, E ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Dog; Endometritis; Renal marker

Indexed keywords

BIOLOGICAL MARKER;

ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DOG DISEASE; ESCHERICHIA COLI INFECTION; FEMALE; KIDNEY DISEASE; MICROBIOLOGY; PYOMETRA; URINE;

ANIMALS; BIOLOGICAL MARKERS; DOG DISEASES; DOGS; ESCHERICHIA COLI INFECTIONS; FEMALE; KIDNEY DISEASES; PYOMETRA;

CANIDAE; CANIS FAMILIARIS; ESCHERICHIA COLI;

EID: 78349244751     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2010.0603.x     Document Type: Article

References (45)

1. Grauer GF. Canine glomerulonephritis: New thoughts on proteinuria and treatment. J Small Anim Pract 2005;46:469-478.
2. Naicker S, Fabian J, Naidoo S, et al. Infection and glomerulonephritis. Semin Immunopathol 2007;29:397-414.
3. Rodriguez-Iturbe B, Musser JM. The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol 2008;19:1855-1864.
4. Asheim A. Pathogenesis of renal damage and polydipsia in dogs with pyometra. J Am Vet Med Assoc 1965;147:736-745.
5. De Schepper J, Van Der Stock J, Capiau E, et al. Renal injury in dogs with pyometra. Tijdschr Diergeneeskd 1987;112 (Suppl 1):124S-126S.
6. Heiene R, Kristiansen V, Teige J, et al. Renal histomorphology in dogs with pyometra and control dogs, and long term clinical outcome with respect to signs of kidney disease. Acta Vet Scand 2007;49:13-22.
7. Heiene R, Moe L, Molmen G. Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra. Res Vet Sci 2001;70:129-137.
8. Obel AL, Nicander L, Asheim A. Light and electron microscopic studies of the renal lesion in dogs with pyometra. Acta Vet Scand 1964;5:93-125.
9. Stone EA, Littman MP, Robertson JL, et al. Renal dysfunction in dogs with pyometra. J Am Vet Med Assoc 1988;193:457-464.
10. Faldyna M, Laznicka A, Toman M. Immunosuppression in bitches with pyometra. J Small Anim Pract 2001;42:5-10.
11. Hagman R, Kindahl H, Fransson BA, et al. Differentiation between pyometra and cystic endometrial hyperplasia/mucometra in bitches by prostaglandin F-2 alpha metabolite analysis. Theriogenology 2006;66:198-206.
12. Sandholm M, Vasenius H, Kivisto AK. Pathogenesis of canine pyometra. J Am Vet Med Assoc 1975;167:1006-1010.
13. Newman SJ, Confer AW, Panciera RJ. Urinary system. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease, 4th ed. St Louis, MO: Mosby-Elsevier; 2006:613-652.
14. Bartoskova A, Vitasek R, Leva L, et al. Hysterectomy leads to fast improvement of haematological and immunological parameters in bitches with pyometra. J Small Anim Pract 2007;48:564-568.
15. Price RG. The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity. Clin Nephrol 1992;38 (Suppl 1):S14-S19.
16. Sarasua SM, Mueller P, Kathman S, et al. Confirming the utility of four kidney biomarker tests in a longitudinal follow-up study. Ren Fail 2003;25:797-817.
17. Stuveling EM, Bakker SJ, Hillege HL, et al. Biochemical risk markers: A novel area for better prediction of renal risk? Nephrol Dial Transplant 2005;20:497-508.
18. Lees GE, Brown SA, Elliott J, et al. Assessment and management of proteinuria in dogs and cats: 2004 ACVIM forum consensus statement (small animal). J Vet Intern Med 2005;19:377-385.
19. D'Amico G, Bazzi C. Pathophysiology of proteinuria. Kidney Int 2003;63:809-825.
20. Maddens B, Daminet S, Demeyere K, et al. Validation of immunoassays for renal biomarkers in canine urine. Vet Immunol Immunopathol 2010;13:259-264.
21. Raila J, Forterre S, Kohn B, et al. Effects of chronic renal disease on the transport of vitamin A in plasma and urine of dogs. Am J Vet Res 2003;64:874-879.
22. Sato R, Soeta S, Miyazaki M, et al. Clinical availability of urinary N-acetyl-beta-D-glucosaminidase index in dogs with urinary diseases. J Vet Med Sci 2002;64:361-365.
23. Imig JD. Eicosanoid regulation of the renal vasculature. Am J Physiol Renal Physiol 2000;279:F965-F981.
24. Nasrallah R, Clark J, Hebert RL. Prostaglandins in the kidney: Developments since Y2K. Clin Sci 2007;113:297-311.
25. Smets P, Meyer E, Maddens B, et al. Urinary markers in healthy young and aged dogs and dogs with chronic kidney disease. J Vet Intern Med 2010;24:65-72.
26. Bigliardi E, Parmigiani E, Cavirani S, et al. Ultrasonography and cystic hyperplasia-pyometra complex in the bitch. Reprod Domest Anim 2004;39:136-140.
27. Grauer GF, Greco DS, Behrend EN, et al. Estimation of quantitative enzymuria in dogs with gentamicin-induced nephrotoxicosis using urine enzyme creatinine ratios from spot urine samples. J Vet Intern Med 1995;9:324-327.
28. Bartels H, Bohmer M, Heierli C. Serum creatinine determination without protein precipitation. Clin Chim Acta 1972;37:193-197.
29. Polzin DJ. Chronic kidney disease. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine. St Louis, MO: Saunders Elsevier; 2010:1990-2021.
30. Zaragoza C, Barrera R, Centeno F, et al. SDS-PAGE and Western blot of urinary proteins in dogs with leishmaniasis. Vet Res 2003;34:137-151.
31. Zaragoza C, Barrera R, Centeno F, et al. Canine pyometra: A study of the urinary proteins by SDS-PAGE and Western blot. Theriogenology 2004;61:1259-1272.
32. Dabrowski R, Wawron W, Kostro K. Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra. Theriogenology 2007;67:321-327.
33. Paltrinieri S. Early biomarkers of inflammation in dogs and cats: The acute phase proteins. Vet Res Commun 2007;31:125-129.
34. Costigan MG, Rustom R, Bone JM, et al. Origin and significance of urinary N-acetyl-beta-D-glucosaminidase (NAG) in renal patients with proteinuria. Clin Chim Acta 1996;255:133-144.
35. Grauer GF. Early detection of renal damage and disease in dogs and cats. Vet Clin North Am Small Anim Pract 2005;35:581-596.
36. Wardle EN. Thromboxanes in glomerulonephritis: What about therapy? Am J Ther 1999;6:111-114.
37. Grauer GF, Frisbie DD, Longhofer SL, et al. Effects of a thromboxane synthetase inhibitor on established immune-complex glomerulonephritis in dogs. Am J Vet Res 1992;53:808-813.
38. Longhofer SL, Frisbie DD, Johnson HC, et al. Effects of thromboxane synthetase inhibition on immune-complex glomerulonephritis. Am J Vet Res 1991;52:480-487.
39. Schellenberg S, Mettler M, Gentilini F, et al. The effects of hydrocortisone on systemic arterial blood pressure and urinary protein excretion in dogs. J Vet Intern Med 2008;22:273-281.
40. Bagley RS, Center SA, Lewis RM, et al. The effect of experimental cystitis and iatrogenic blood contamination on the urine protein/creatine ratio in the dog. J Vet Intern Med 1991;5:66-70.
41. Vaden SL, Pressler BM, Lappin MR, et al. Effects of urinary tract inflammation and sample blood contamination on urine albumin and total protein concentrations in canine urine samples. Vet Clin Pathol 2004;33:14-19.
42. Smets P, Meyer E, Maddens B, et al. Effect of sampling method and storage conditions on albumin, retinol-binding protein and N-acetyl-β-D-glucosaminidase concentrations in canine urine samples. J Vet Diagn Invest 2010;22. In press.
43. Neuwirth L, Mahaffey M, Crowell W, et al. Comparison of excretory urography and ultrasonography for detection of experimentally induced pyelonephritis in dogs. Am J Vet Res 1993;54:660-669.
44. LaClair R, O'Neal K, Ofner S, et al. Precision of biomarkers to define chronic inflammation in CKD. Am J Nephrol 2008;28:808-812.
45. Zeledon JI, McKelvey RL, Servilla KS, et al. Glomerulonephritis causing acute renal failure during the course of bacterial infections. Histological varieties, potential pathogenetic pathways and treatment. Int Urol Nephrol 2008;40:461-470.