Canine glomerulonephritis: New thoughts on proteinuria and treatment

Journal of Small Animal Practice

Volumn 46, Issue 10, 2005, Pages 469-478

  Grauer, G F ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ANIMAL; ANIMAL DISEASE; ANTIGEN ANTIBODY COMPLEX; CHRONIC KIDNEY FAILURE; DISEASE COURSE; DOG; DOG DISEASE; GLOMERULONEPHRITIS; METABOLISM; PATHOLOGY; PROTEINURIA; REVIEW; TIME;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; DISEASE PROGRESSION; DOG DISEASES; DOGS; GLOMERULONEPHRITIS; KIDNEY FAILURE, CHRONIC; PROTEINURIA; TIME FACTORS;

CANIS FAMILIARIS;

EID: 27144467525     PISSN: 00224510     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-5827.2005.tb00275.x     Document Type: Review

References (73)

1. ALFREY, A. C., FROMENT, D. H. & HAMMOND, W. S. (1989) Role of iron in tubulointerstitial injury in nephrotoxic serum nephritis. Kidney International 36, 753-759
2. BARSANTI, J. A. & FINCO, D. R. (1979) Protein concentration in urine of normal dogs. American Journal of Veterinary Research 40, 1583-1588
3. BENIGNI, A., ZOJA, C. & REMUZZI, G. (1995) Biology of disease: the renal toxicity of sustained glomerular protein traffic. Laboratory Investigation 73, 461-468
4. BERTANI, T., CUTILLO, F., ZOJA, C., BROGGINI, M. & REMUZZI, G. (1986) Tubulointerstitial lesions mediate renal damage in adriamycin glomerulopathy. Kidney International 30, 488-496
5. BIANCHI, S., BIGAZZI, R. & CAMPESE, V. M. (1999) Microalbuminuria in essential hypertension: significance, pathophysiology and therapeutic implications. American Journal of Kidney Disease 6, 973-995
6. BIEWENGA, W. I., GRUYS, E. & HENDRIKS, H. I. (1983) Urinary protein loss in the dog: nephrological study of 29 dogs without signs of renal disease. Research in Veterinary Science 33, 366-374
7. BOHLE, A., WEHRMANN, M., BOGENSHUTZ, O., BATZ, C., VOGL, W., SCHMITT, H., MULLER, C. A. & MULLER, G. A. (1992) The long-term prognosis of the primary glomerulonephritides. A morphological and clinical analysis of 1747 cases. Pathology, Research and Practice 188, 908-924
8. BRENNER, B. M., MEYER, T. W. & HOSTETTER, T. H. (1982) Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. New England Journal of Medicine 307, 652-659
9. BROWN, E. A., MARKANDU, N. D., ROULSTON, I. E., JONES, B. E., SQUIRES, M. & MACGREGOR, G. A. (1982) Is the renin-angiotensin-aldosterone system involved in the sodium retention in the nephrotic syndrome? Nephron 32, 102-107
10. BROWN, S. A., BROWN, C. A., CROWELL, W. A., BARSANTI, J. A., ALLEN, T., COWELL, C. & FINCO, D. R. (1998) Beneficial effects of chronic administration of dietary n-3 polyunsaturated fatty acids in dogs with renal insufficiency. Journal of Laboratory Clinical Medicine 131, 447-455
11. BROWN, S. A., WALTON, C. L., CRAWFORD, P. & BAKRIS, G. L. (1993) Long-term effects of antihypertensive regimens on renal hemodynamics and proteinuria. Kidney International 43, 1210-1218
12. BURKHOLDER, W. J., LEES, G. E., LEBLANC, A. K., SLATER, M. R., BAUER, J. E., KASHTAN, C. E., MCCRACKEN, B. A. & HANNAH, S. S. (2004) Diet modulates proteinuria in heterozygous female dogs with X-linked hereditary nephropathy. Journal of Veterinary Internal Medicine 18, 165-175
13. CAMUSSI, G. (1994) Alternative pathway activation of complement by cultured human proximal tubular epithelial cells. Kidney International 45, 451-460
14. CENTER, S. A., SMITH, C. A., WILKINSON, E., ERB, H. N. & LEWIS, R. M. (1987) Clinicopathologic, renal immunofluorescent, and light microscopic features of GN in the dog: 41 cases (1975-1985). Journal of the American Veterinary Medical Association 190, 81-90
15. CENTER, S. A., WILKINSON, E., SMITH, C. A., ERB, H. N. & LEWIS, R. M. (1985) 24-hour urine protein/creatinine ratio in dogs with protein losing nephropathies. Journal of the American Veterinary Medical Association 187, 820-824
16. CLARK, W. F., FRIESEN, M., LINTON, A. L. & LINDSAY, R. M. (1976) The platelet as a mediator of tissue damage in immune complex GN. Clinical Nephrology 6, 287-289
17. COOK, A. K. & COWGILL, L. D. (1996) Clinical and pathologic features of protein-losing glomerular disease in the dog: a review of 137 cases. Journal of the American Animal Hospital Association 32, 313-322
18. COWGILL, L. D. (1991) Clinical significance, diagnosis and management of systemic hypertension in dogs and cats. In: Managing Renal Disease and Hypertension. Hill's Pet Products and Harmon Smith. pp 35-44
19. DIBARTOLA, S. P., CHEW, D. J. & JACOBS, G. (1980a) Quantitative urinalysis including 24-hour protein excretion in the dog. Journal of the American Animal Hospital Association 16, 537-546
20. DIBARTOLA, S. P., SPAULDING, G. L., CHEW, D. J. & LEWIS, R. M. (1980b) Urinary protein excretion and immunopathologic findings in dogs with glomerular disease. Journal of the American Veterinary Medical Association 177, 73-77
21. EPSTEIN, M. (2001) Aldosterone as a mediator of progressive renal disease: pathogenic and clinical implications. American Journal of Kidney Disease 37, 677-688
22. GOSLING, P. (1995) Microalbuminuria: a marker of systemic disease. British Journal of Hospital Medicine 54, 285-290
23. GRAUER, G. F. (1991) Glomerular disease and proteinuria. In: Small Animal Medicine. Ed D. G. Allen. Lippincott Williams & Wilkins, Philadelphia. pp 615-623
24. GRAUER, G. F., CULHAM, C. A., DUBIELZIG, R. R., LONGHOFER, S. L. & GRIEVE, R. B. (1989) Experimental Dirofilaria immitis-associated GN induced in part by in situ formation of immune complexes in the glomerular capillary wall. Journal of Parasitology 75, 585-593
25. GRAUER, G. F., FRISBIE, D. D., LONGHOFER, S. L. & COOLEY, A. J. (1992a) Effects of a thromboxane synthetase inhibitor on established immune complex GN in dogs. American Journal of Veterinary Research 53, 808-813
26. GRAUER, G. F., GRECO, D. S., GETZY, D. M., COWGILL, L. D., VADEN, S. L., CHEW, D. J., POLZIN, D. J. & BARSANTI, J. A. (2000) Effects of enalapril vs placebo as a treatment for canine idiopathic glomerulonephritis. Journal of Veterinary Internal Medicine 14, 526-533
27. GRAUER, G. F., MOORE, L. E., SMITH, A. R. & JENSEN, W. A. (2004) Comparison of conventional urine protein test strips and a quantitative ELISA for the detection of canine and feline albuminuria. Journal of Veterinary Internal Medicine 18, 418-419
28. GRAUER, G. F., OBERHAUSER, E. B. & BASARABA, R. J. (2002) Development of microalbuminuria in dogs with heartworm disease. Journal of Veterinary Internal Medicine 16, 352
29. GRAUER, G. F., ROSE, B. J., TOOLAN, L., THRALL, M. A. & COLGAR, S. P. (1992b) Comparison of the effects of low-dose aspirin and specific thromboxane synthetase inhibition on whole blood platelet aggregation ATP secretion in healthy dogs. American Journal of Veterinary Research 53, 1631-1635
30. GRAUER, G. F., THOMAS, C. B. & EICKER, S. W. (1985) Estimation of quantitative proteinuria in the dog, using the urine protein-to-creatinine ratio from a random, voided sample. American Journal of Veterinary Research 46, 2116-2119
31. GRAUER, G. F., TWEDT, D. C. & MERO, K. N. (1983) Evaluation of laparoscopy for obtaining renal biopsy specimens from dogs and cats. Journal of the American Veterinary Medical Association 183, 677-679
32. GREEN, R. A. & KABEL, A. L. (1982) Hypercoagulable state in three dogs with nephrotic syndrome: role of acquired antithrombin III deficiency. Journal of the American Veterinary Medical Association 181, 914-917
33. GREEN, R. A., RUSSO, E. A., GREENE, R. T. & KABEL, A. L. (1985) Hypoalbuminemia-related platelet hypersensitivity in two dogs with nephrotic syndrome. Journal of the American Veterinary Medical Association 186, 485-488
34. GRODECKI, K. M., GAINS, M. J., BAUMAL, R., OSMOND, D. H., COTTER, B., VALLI, V. E. & JACOBS, R. M. (1997) Treatment of X-linked hereditary nephritis in Samoyed dogs with angiotensin converting enzyme (ACE) inhibitor. Journal of Comparative Pathology 117, 209-225
35. HAGER, D. A., NYLAND, T. G. & FISHER, P. (1985) Ultrasound-guided biopsy of the canine liver, kidney and prostate. Veterinary Radiology 26, 82-88
36. HARRIS, K. P., BURTON, C. & WALLS, J. (1996) Proteinuria: a mediator of interstitial fibrosis? Contributions to Nephrology 118, 173-179
37. HAYSLETT, I. P. (1984) Role of platelets in glomerulonephritis. New England Journal of Medicine 310, 1457-1458
38. HENSON, P. M. (1971) Interaction of cells with immune complexes: adherence, release of constituents, and tissue injury. Journal of Experimental Medicine 134, 114s-135s
39. HILGERS, K. F. & MANN, J. F. E. (1996) Role of angiotensin II in glomerular injury: lessons from experimental and clinical studies. Kidney and Blood Pressure Research 19, 254-262
40. JAENKE, R. S. & ALLEN, T. A. (1986) Membranous nephropathy in the dog. Veterinary Pathology 23, 718-733
41. JENSEN, W. A., GRAUER, G. F., ANDREWS, J. & SIMPSON, D. (2001) Prevalence of microalbuminuria in dogs. Journal of Veterinary Internal Medicine 15, 300
42. JERAJ, K., OSBORNE, C. A. & STEVENS, J. B. (1982) Evaluation of renal biopsy in 197 dogs and cats. Journal of the American Veterinary Medical Association 181, 367-369
43. JERUMS, G., PANAGIOTOPOULOS, S., TSALAMANDRIS, C., ALLEN, T. J., GILBERT, R. E. & COMPER, W. D. (1997) Why is proteinuria such an important risk factor for progression in clinical trials? Kidney International 52, S87-S92
44. JOHNSON, R. J. (1997) Cytokines, growth factors and renal injury: where do we go now? Kidney International 52, S2-S6
45. KEILANI, T., SCHLUETER, W. A., LEVIN, M. L. & BATLLE, D. C. (1993) Improvement of lipid abnormalities associated with proteinuria using fosinopril, an angiotensin-converting enzyme inhibitor. Annals of Internal Medicine 118, 246-254
46. KINCAID-SMITH, P. (1972) Coagulation and renal disease. Kidney International 2, 183-190
47. LEES, G. E., JENSEN, W. A., SIMPSON, D. F. & KASHTAN, C. E. (2002a) Persistent albuminuria precedes onset of overt proteinuria in male dogs with X-linked hereditary nephropathy. Journal of Veterinary Internal Medicine 16, 353
48. LEES, G. E., WILLARD, M. D. & DZIEZUC, J. (2002b) Glomerular proteinuria is rapidly but reversibly increased by short-term prednisone administration in heterozygous (carrier) female dogs with X-linked hereditary nephropathy. Journal of Veterinary Internal Medicine 16, 352
49. LONGHOFER, S. L., FRISBIE, D. D., JOHNSON, H. C., CULHAM, C. A., COOLEY, A. J., SCHULTZ, K. T. & GRAUER, G. F. (1991) Effects of a thromboxane synthetase inhibitor on immune complex GN. American Journal of Veterinary Research 52, 480-487
50. MCCAW, D. L., KNAPP, D. W. & HEWET, J. E. (1985) Effect of collection and exercise restriction on the prediction of urine protein excretion, using urine protein/creatinine ratio in dogs. American Journal of Veterinary Research 46, 1665-1669
51. MACDOUGALL, D. F., COOK, T., STEWARD, A. P. & CATTELL, V. (1986) Canine chronic renal disease: prevalence and types of GN in the dog. Kidney International 29, 1144-1151
52. MATHEWS, K. A., HOLMBERG, D. L. & MILLER, C. W. (2000) Kidney transplantation in dogs with naturally occurring end-stage renal disease. Journal of the American Animal Hospital Association 36, 294-301
53. MULLER-PEDDINGHAUS, R. & TRAUTWEIN, G. (1977) Spontaneous GN in dogs 1. Classification and immunopathology. Veterinary Pathology 14, 1-13
54. OLBRICHT, C. J., CANNON, J. K., GARG, L. C. & TISHER, C. C. (1986) Activities of cathepsin B and L in isolated nephron segments from proteinuric and nonproteinuric rats. American Journal of Physiology 250, F1055-F1062
55. ONG, A. & MOORHEAD, J. (1994) Tubular lipidosis: epiphenomenon or pathogenetic lesion in human renal disease. Kidney International 45, 753-762
56. PINTO-SIETSMA, S. J., JANSSEN, W. M. T., HILLEGE, H. L., NAVIS, G., DE ZEEUW, D. & DE JONG, P. E. (2000) Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. Journal of the American Society of Nephrology 10, 1882-1888
57. PRESSLER, B. M., PROULX, D. A. & WILLIAMS, L. E. (2003) Urine albumin concentration is increased in dogs with lymphoma or osteosarcoma. Journal of Veterinary Internal Medicine 17, 404
58. PRESSLER, B. M., VADEN, S. L. & JENSEN, W. A. (2001) Prevalence of microalbuminuria in dogs evaluated at a referral veterinary hospital. Journal of Veterinary Internal Medicine 15, 300
59. RADECKI, S., DONNELLY, R., JENSEN, W. A. & STINCHCOMB, D. T. (2003) Effect of age and breed on the prevalence of microalbuminuria in dogs. Journal of Veterinary Internal Medicine 17, 406
60. REDDI, A. S., RAMAMURTHI, R., MILLER, M., DHUPER, S. & LASKER, N. (1991) Enalapril improves albuminuria by preventing glomerular loss of heparan sulfate in diabetic rats. Biochemical Medicine and Metabolic Biology 45, 119-131
61. REMUZZI, G. (1995) Abnormal protein traffic through the glomerular barrier induces proximal tubular cell dysfunction and causes renal injury. Current Opinion in Nephrology and Hypertension 4, 339-342
62. ROUSE, B. T. & LEWIS, R. J. (1975) Canine glomerulonephritis: prevalence in dogs submitted at random for euthanasia. Canadian Journal of Comparative Medicine 39, 365-370
63. TANG, S., SHEERIN, N. S., ZHOU, W., BROWN, Z. & SACKS, S. H. (1999) Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. Journal of the American Society of Nephrology 10, 69-76
64. VADEN, S. L., BREITSCHWERDT, E. B., ARMSTRONG, P. J., CORREA, M. T., BROWN, C., POLZIN, D. J., BRACE, J. J., DIBARTOLA, S. P., BARSANTI, J. A., CROWELL, W., et al (1995) The effects of cyclosporin versus standard care in dogs with naturally occurring glomerulonephritis. Journal of Veterinary Internal Medicine 9, 259-266
65. VADEN, S. L., JENSEN, W. A., LONGHOFER, S. L. & SIMPSON, D. F. (2001) Longitudinal study of microalbuminuria in soft-coated wheaten terriers. Journal of Veterinary Internal Medicine 15, 300
66. VADEN, S. L., PRESSLER, B. M. & LAPPIN, M. R. (2002) Urinary tract inflammation has a variable effect on urine albumin concentrations. Journal of Veterinary Internal Medicine 16, 378
67. VASSALLI, P. & MCCLUSKEY, R. T. (1964) The pathogenetic role of fibrin deposition in immunologically induced GN. Annals of the New York Academy of Sciences 116, 1052-1062
68. WEIL, G. I., MALANE, M. S. & POWERS, K. G. (1985) Monoclonal antibodies to parasite antigens found in the serum of Dirofilaria immitis-infected dogs. Journal of Immunology 134, 1185-1191
69. WEIR, M. R. (2002) Microalbuminuria as a cardiovascular and renal risk factor in patients with type 2 diabetes. American Journal of Clinical Procedures 3, 7-14
70. WHEELER, D. C., VARGHESE, Z. & MOORHEAD, I. F. (1989) Hyperlipidemia in nephrotic syndrome. American Journal of Nephrology 9, S78-S84
71. WHITE, J. V., OLIVIER, B. & REIMAN, K. (1984) Use of protein-to-creatinine ratio in a single urine specimen for quantitative estimation of canine proteinuria. Journal of the American Veterinary Medical Association 185, 882-885
72. WHITTEMORE, J. C., JENSEN, W. A., PRAUSE, L. & RADECKI, S. (2003) Comparison of microalbuminuria, urine dipstick and urine protein creatinine ratio results in clinically ill dogs. Journal of Veterinary Internal Medicine 17, 437
73. WIEGMANN, T. B., HERRON, K. G., CHONKO, A. M., MACDOUGALL, M. L. & MOORE, W. V. (1992) Effects of angiotensin-converting enzyme inhibition on renal function and albuminuria in normotensive type I diabetic patients. Diabetes 41, 62-67