Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease

Archiv der Pharmazie

Volumn 343, Issue 10, 2010, Pages 590-601

  Badran, Mohga M ^a   Hakeem, Maha Abdel ^a   Abuel Maaty, Suzan M ^a   El Malah, Afaf ^a   Salam, Rania M Abdel ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

AChE (Acetylcholine esterase); Alzheimer's disease; Docking; Tacrine analogues; Thienopyridines

Indexed keywords

10 AMINO 2,3,6,7,8,9 HEXAHYDRO 1H [1]BENZOTHIENO[2,3 B]CYCLOPENTA[E]PYRIDINE; 10 AMINO 2,3,6,7,8,9 HEXAHYDRO 1H CYCLOPENTA[4,5] THIENO[2,3-B]QUINOLINE; 11 AMINO 1,2,3,4,7,8,9,10 OCTAHYDRO[1]BENZOTHIENO[2,3-B]QUINOLINE; 11 AMINO 2 METHYL 1,2,3,4,7,8,9,10 OCTAHYDRO[1]BENZOTHIENO[2,3-B][1,6]NAPHTHA-PYRIDINE; 11 AMINO 7,12,12 TRIMETHYL 7,10 METHANO 1,2,3,4,7,8,9,10 OCTAHYDRO[1]BENZO THIENO[2,3-B]QUINOLINE; 11 AMINO1,2,3,10 TETRAHYDROCYCLOPENTA[4,5]THIENO[2,3-B]INDENO[2',1'-E]PYRIDINE; 12 AMINO 2,3,4,11 TETRAHYDRO 1H [1]BENZOTHIENO[2,3-B]INDENO[2',1'-E]PYRIDINE; 12 AMINO 2,3,6,11 TETRAHYDRO 1H CYCLOPENTA[4,5]THIENO[2,3-B]BENZO[G]QUINOLINE; 13 AMINO 1,2,3,4,7,12 HEXAHYDRO[1]BENZOTHIENO [3',2':5,6]PYRIDO[2,3-B]QUINOLINE; 13 AMINO 1,2,3,4,7,12 HEXAHYDRO[1]BENZOTHIENO[2,3-B]BENZO[G]QUINOLINE; 4 AMINO 2,3 DIMETHYL 5,10 DIHYDROTHIENO[2,3-B]BENZO[G]QUINOLINE; 4 AMINO 2,3 DIMETHYL 5,6,7,8 TETRAHYDROTHIENO[2,3-B]QUINOLONE; 4 AMINO 2,3 DIMETHYL 5H THIENO[2,3-B]INDENO[2',1'-E]PYRIDINE; 4 AMINO 2,3 DIMETHYL 6,7 DIHYDRO 5H THIENO [2,3-B] CYCLOPENTA[E]PYRIDINE; 9 AMINO 1,2,3,6,7,8 HEXAHYDROCYCLOPENTA[4,5]THIENO[2,3-B]CYCLOPENTA[E]PYRIDINE; AMINOTHIENOPYRIDINE; CHOLINESTERASE INHIBITOR; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RAT;

ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE; THIENOPYRIDINES;

EID: 78349241400     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900226     Document Type: Article

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