Gene expression profile of the skin in the 'hairpoor' (HrHp) mice by microarray analysis

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Kim, Bong Kyu ^a   Baek, In Cheol ^a   Lee, Hwa Young ^a   Kim, Jeong Ki ^a   Song, Hae Hiang ^a   Yoon, Sungjoo K ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 14; HAIRLESS PROTEIN; MEMBRANE PROTEIN; PROTEIN KRT71; PROTEIN WIF1; SECRETED FRIZZLED RELATED PROTEIN 1; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENOTYPE; HAIR FOLLICLE; HETEROZYGOSITY; HOMOZYGOSITY; KERATINOCYTE; MICROARRAY ANALYSIS; MORPHOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN FOLDING; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; AGING; ANIMAL; CELL LINE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAIRLESS MOUSE; METABOLISM; PATHOLOGY; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN;

ANIMALIA; MUS;

AGING; ANIMALS; CELL LINE; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAIR FOLLICLE; KERATINOCYTES; MICE; MICE, HAIRLESS; MORPHOGENESIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; TRANSFECTION; UP-REGULATION;

EID: 78349234318     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-640     Document Type: Article

References (35)

1. Hardy MH. The secret life of the hair follicle. Trends Genet 1992, 8(2):55-61. 10.1016/0168-9525(92)90350-D, 1566372.
2. Cachon-Gonzalez MB, Fenner S, Coffin JM, Moran C, Best S, Stoye JP. Structure and expression of the hairless gene of mice. Proc Natl Acad Sci USA 1994, 91(16):7717-7721. 10.1073/pnas.91.16.7717, 44473, 8052649.
3. Thompson CC, Bottcher MC. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc Natl Acad Sci USA 1997, 94(16):8527-8532. 10.1073/pnas.94.16.8527, 22986, 9238010.
4. Potter GB, Beaudoin GM, DeRenzo CL, Zarach JM, Chen SH, Thompson CC. The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev 2001, 15(20):2687-2701. 10.1101/gad.916701, 312820, 11641275.
5. Hsieh JC, Sisk JM, Jurutka PW, Haussler CA, Slater SA, Haussler MR, Thompson CC. Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. J Biol Chem 2003, 278(40):38665-38674. 10.1074/jbc.M304886200, 12847098.
6. Moraitis AN, Giguere V, Thompson CC. Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants. Mol Cell Biol 2002, 22(19):6831-6841. 10.1128/MCB.22.19.6831-6841.2002, 134023, 12215540.
7. Zarach JM, Beaudoin GM, Coulombe PA, Thompson CC. The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development 2004, 131(17):4189-4200. 10.1242/dev.01303, 15280217.
8. Ahmad W, Panteleyev AA, Sundberg JP, Christiano AM. Molecular basis for the rhino (hrrh-8J) phenotype: a nonsense mutation in the mouse hairless gene. Genomics 1998, 53(3):383-386. 10.1006/geno.1998.5495, 9799606.
9. Mann SJ. Hair loss and cyst formation in hairless and rhino mutant mice. Anat Rec 1971, 170(4):485-499. 10.1002/ar.1091700409, 5118596.
10. Cachon-Gonzalez MB, San-Jose I, Cano A, Vega JA, Garcia N, Freeman T, Schimmang T, Stoye JP. The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype. Dev Dyn 1999, 216(2):113-126. 10.1002/(SICI)1097-0177(199910)216:2<113::AID-DVDY3>3.0.CO;2-M, 10536052.
11. Brancaz MV, Iratni R, Morrison A, Mancini SJ, Marche P, Sundberg J, Nonchev S. A new allele of the mouse hairless gene interferes with Hox/LacZ transgene regulation in hair follicle primordia. Exp Mol Pathol 2004, 76(2):173-181. 10.1016/j.yexmp.2003.10.003, 15010296.
12. Zhang JT, Fang SG, Wang CY. A novel nonsense mutation and polymorphisms in the mouse hairless gene. J Invest Dermatol 2005, 124(6):1200-1205. 10.1111/j.0022-202X.2005.23744.x, 15955095.
13. Panteleyev AA, Ahmad W, Malashenko AM, Ignatieva EL, Paus R, Sundberg JP, Christiano AM. Molecular basis for the rhino Yurlovo (hr(rhY)) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene. Exp Dermatol 1998, 7(5):281-288. 10.1111/j.1600-0625.1998.tb00298.x-i1, 9832316.
14. Liu Y, Sundberg JP, Das S, Carpenter D, Cain KT, Michaud EJ, Voy BH. Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R) in the hairless gene (Hr). Vet Pathol 47(1):167-176. 10.1177/0300985809352970, 20080498.
15. Baek IC, Kim JK, Cho KH, Cha DS, Cho JW, Park JK, Song CW, Yoon SK. A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis. Mamm Genome 2009, 20(6):350-358. 10.1007/s00335-009-9191-8, 19513791.
16. Kim JK, Kim E, Baek IC, Kim BK, Cho AR, Kim TY, Song CW, Seong JK, Yoon JB, Stenn KS, et al. Overexpression of Hr links excessive induction of Wnt signaling to Marie Unna hereditary hypotrichosis. Hum Mol Genet 19(3):445-453. 10.1093/hmg/ddp509, 19897589.
17. Wen Y, Liu Y, Xu Y, Zhao Y, Hua R, Wang K, Sun M, Li Y, Yang S, Zhang XJ, et al. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet 2009, 41(2):228-233. 10.1038/ng.276, 19122663.
18. Liu Y, Das S, Olszewski RE, Carpenter DA, Culiat CT, Sundberg JP, Soteropoulos P, Liu X, Doktycz MJ, Michaud EJ, et al. The near-naked hairless (Hr(N)) mutation disrupts hair formation but is not due to a mutation in the Hairless coding region. J Invest Dermatol 2007, 127(7):1605-1614.
19. Andl T, Reddy ST, Gaddapara T, Millar SE. WNT signals are required for the initiation of hair follicle development. Dev Cell 2002, 2(5):643-653. 10.1016/S1534-5807(02)00167-3, 12015971.
20. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 2001, 105(4):533-545. 10.1016/S0092-8674(01)00336-1, 11371349.
21. Beaudoin GM, Sisk JM, Coulombe PA, Thompson CC. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci USA 2005, 102(41):14653-14658. 10.1073/pnas.0507609102, 1253615, 16195376.
22. Eckhart L, Ban J, Fischer H, Tschachler E. Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation. Biochem Biophys Res Commun 2000, 277(3):655-659. 10.1006/bbrc.2000.3698, 11062009.
23. Nishio H, Matsui K, Tsuji H, Tamura A, Suzuki K. Immunolocalisation of the janus kinases (JAK)--signal transducers and activators of transcription (STAT) pathway in human epidermis. J Anat 2001, 198(Pt 5):581-589. 10.1046/j.1469-7580.2001.19850581.x, 1468247, 11430697.
24. Eckhart L, Declercq W, Ban J, Rendl M, Lengauer B, Mayer C, Lippens S, Vandenabeele P, Tschachler E. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation. J Invest Dermatol 2000, 115(6):1148-1151. 10.1046/j.1523-1747.2000.00205.x, 11121154.
25. Runkel F, Klaften M, Koch K, Bohnert V, Bussow H, Fuchs H, Franz T, Hrabe de Angelis M. Morphologic and molecular characterization of two novel Krt71 (Krt2-6) mutations: Krt71rco12 and Krt71rco13. Mamm Genome 2006, 17(12):1172-1182. 10.1007/s00335-006-0084-9, 17143583.
26. Whitbread LA, Powell BC. Expression of the intermediate filament keratin gene K15, in the basal cell layers of epithelia and the hair follicle. Exp Cell Res 1998, 244(2):448-459. 10.1006/excr.1998.4217, 9806795.
27. Hamada K, Ozawa K, Itami S, Yoshikawa K. Human fibroblast growth factor 10 expression in dermal papilla cells, outer root sheath cells and keratinocytes. Exp Dermatol 1999, 8(4):347-349.
28. Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci USA 1997, 94(13):6770-6775. 10.1073/pnas.94.13.6770, 21233, 9192640.
29. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 1999, 398(6726):431-436. 10.1038/18899, 10201374.
30. Thompson CC, Sisk JM, Beaudoin GM. Hairless and Wnt signaling: allies in epithelial stem cell differentiation. Cell Cycle 2006, 5(17):1913-1917.
31. Alibardi L, Tschachler E, Eckhart L. Distribution of caspase-14 in epidermis and hair follicles is evolutionarily conserved among mammals. Anat Rec A Discov Mol Cell Evol Biol 2005, 286(2):962-973.
32. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001, 98(1):31-36. 10.1073/pnas.011404098, 14539, 11134512.
33. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98(9):5116-5121. 10.1073/pnas.091062498, 33173, 11309499.
34. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003, 100(16):9440-9445. 10.1073/pnas.1530509100, 170937, 12883005.
35. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25(4):402-408. 10.1006/meth.2001.1262, 11846609.