Tempol, a superoxide dismutase mimetic, prevents cerebral vessel remodeling in hypertensive rats

Microvascular Research

Volumn 80, Issue 3, 2010, Pages 445-452

  Pires, Paulo Wagner ^a   Deutsch, Christian ^b   McClain, Jonathon Lee ^a   Rogers, Curt Thomas ^a   Dorrance, Anne McLaren ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Middle cerebral artery; SHRSP; Stroke; Tempol; Vascular remodeling

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN TYPE 4; MALONALDEHYDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SEROTONIN; TEMPOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY DIAMETER; ARTERY TONE; ARTICLE; BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION; HYPERTENSION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MYOGRAPHY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; STROKE; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; TREATMENT DURATION; VASOCONSTRICTION;

ANIMALS; BLOOD PRESSURE; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; HYPERTENSION; MALE; MIDDLE CEREBRAL ARTERY; MYOGRAPHY; RATS; RATS, INBRED SHR; REACTIVE OXYGEN SPECIES; SPIN LABELS; STROKE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

RATTUS;

EID: 78249260878     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2010.06.004     Document Type: Article

References (44)

1. Alberts M.J., Ovbiagele B. Current strategies for ischemic stroke prevention: role of multimodal combination therapies. J. Neurol. 2007, 254(10):1414-1426.
2. Baumbach G.L., Ghoneim S. Vascular remodeling in hypertension. Scanning Microsc. 1993, 7(1):137-142. (discussion 143).
3. Baumbach G.L., Hajdu M.A. Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats. Hypertension 1993, 21(6 Pt 1):816-826.
4. Bonacasa B., Sanchez M.L., Rodriguez F., Lopez B., Quesada T., Fenoy F.J., Hernandez I. 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats. Maturitas 2008, 61(4):310-316.
5. Briones A.M., Rodriguez-Criado N., Hernanz R., Garcia-Redondo A.B., Rodrigues-Diez R.R., Alonso M.J., Egido J., Ruiz-Ortega M., Salaices M. Atorvastatin prevents angiotensin II-induced vascular remodeling and oxidative stress. Hypertension 2009, 54(1):142-149.
6. Castro M.M., Rizzi E., Rodrigues G.J., Ceron C.S., Bendhack L.M., Gerlach R.F., Tanus-Santos J.E. Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic. Biol. Med. 2009, 46(9):1298-1307.
7. Chen X., Touyz R.M., Park J.B., Schiffrin E.L. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension 2001, 38(3 Pt 2):606-611.
8. D'Armiento J. Decreased elastin in vessel walls puts the pressure on. J. Clin. Invest. 2003, 112(9):1308-1310.
9. De Keulenaer G.W., Chappell D.C., Ishizaka N., Nerem R.M., Alexander R.W., Griendling K.K. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase. Circ. Res. 1998, 82(10):1094-1101.
10. DeMarco V.G., Habibi J., Whaley-Connell A.T., Schneider R.I., Heller R.L., Bosanquet J.P., Hayden M.R., Delcour K., Cooper S.A., Andresen B.T., Sowers J.R., Dellsperger K.C. Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat. Am. J. Physiol. Heart Circ. Physiol. 2008, 294(6):H2659-H2668.
11. Dorrance A.M., Pollock D.M., Romanko O.P., Stepp D.W. A high-potassium diet reduces infarct size and improves vascular structure in hypertensive rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292(1):R415-R422.
12. Everett, B.M., Glynn, R.J., MacFadyen, J.G., Ridker, P.M., 2010. Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circulation 121(1): 143-150.
13. Faraci F.M., Modrick M.L., Lynch C.M., Didion L.A., Fegan P.E., Didion S.P. Selective cerebral vascular dysfunction in Mn-SOD-deficient mice. J. Appl. Physiol. 2006, 100(6):2089-2093.
14. phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ. Res. 1997, 80(1):45-51.
15. Heagerty A.M., Aalkjaer C., Bund S.J., Korsgaard N., Mulvany M.J. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension 1993, 21(4):391-397.
16. Junqueira L.C., Bignolas G., Brentani R.R. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem. J. 1979, 11(4):447-455.
17. Junquiera L.C., Junqueira L.C., Brentani R.R. A simple and sensitive method for the quantitative estimation of collagen. Anal. Biochem. 1979, 94(1):96-99.
18. Kumai Y., Ooboshi H., Ago T., Ishikawa E., Takada J., Kamouchi M., Kitazono T., Ibayashi S., Iida M. Protective effects of angiotensin II type 1 receptor blocker on cerebral circulation independent of blood pressure. Exp. Neurol. 2008, 210(2):441-448.
19. Laurindo F.R., Pedro Mde A., Barbeiro H.V., Pileggi F., Carvalho M.H., Augusto O., da Luz P.L. Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism. Circ. Res. 1994, 74(4):700-709.
20. Lee R.M. Morphology of cerebral arteries. Pharmacol. Ther. 1995, 66(1):149-173.
21. Lemarie C.A., Tharaux P.L., Esposito B., Tedgui A., Lehoux S. Transforming growth factor-alpha mediates nuclear factor kappaB activation in strained arteries. Circ. Res. 2006, 99(4):434-441.
22. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79(4):1431-1568.
23. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
24. Lloyd-Jones D., Adams R.J., Brown T.M., Carnethon M., Dai S., De Simone G., Ferguson T.B., Ford E., Furie K., Gillespie C., Go A., Greenlund K., Haase N., Hailpern S., Ho P.M., Howard V., Kissela B., Kittner S., Lackland D., Lisabeth L., Marelli A., McDermott M.M., Meigs J., Mozaffarian D., Mussolino M., Nichol G., Roger V., Rosamond W., Sacco R., Sorlie P., Stafford R., Thom T., Wasserthiel-Smoller S., Wong N.D., Wylie-Rosett J. Heart disease and stroke statistics-2010 update. A report from the American Heart Association. Circulation 2009, 121(7):e46-e215.
25. Loomis E.D., Sullivan J.C., Osmond D.A., Pollock D.M., Pollock J.S. Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. J. Pharmacol. Exp. Ther. 2005, 315(3):1058-1064.
26. Moro M.A., Almeida A., Bolanos J.P., Lizasoain I. Mitochondrial respiratory chain and free radical generation in stroke. Free Radic Biol. Med. 2005, 39(10):1291-1304.
27. Nagata D., Takahashi M., Sawai K., Tagami T., Usui T., Shimatsu A., Hirata Y., Naruse M. Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity. Hypertension 2006, 48(1):165-171.
28. Ozawa Y., Hayashi K., Kanda T., Homma K., Takamatsu I., Tatematsu S., Yoshioka K., Kumagai H., Wakino S., Saruta T. Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats. Nephrology (Carlton) 2004, 9(5):272-277.
29. Paravicini T.M., Touyz R.M. Redox signaling in hypertension. Cardiovasc. Res. 2006, 71(2):247-258.
30. Park J.B., Touyz R.M., Chen X., Schiffrin E.L. Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. Am. J. Hypertens. 2002, 15(1 Pt 1):78-84.
31. Piantadosi C.A., Zhang J. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 1996, 27(2):327-331. (discussion 332).
32. Planas A.M., Soriano M.A., Rodriguez-Farre E., Ferrer I. Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain. Neurosci. Lett. 1995, 200(3):187-190.
33. Ridker P.M., Danielson E., Fonseca F.A., Genest J., Gotto A.M., Kastelein J.J., Koenig W., Libby P., Lorenzatti A.J., MacFadyen J.G., Nordestgaard B.G., Shepherd J., Willerson J.T., Glynn R.J. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 2008, 359(21):2195-2207.
34. Rigsby C.S., Pollock D.M., Dorrance A.M. Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats. Microvasc. Res. 2007, 73(3):198-205.
35. Sakurabayashi-Kitade S., Aoka Y., Nagashima H., Kasanuki H., Hagiwara N., Kawana M. Aldosterone blockade by spironolactone improves the hypertensive vascular hypertrophy and remodeling in angiotensin II overproducing transgenic mice. Atherosclerosis 2009, 206(1):54-60.
36. Sprague A.H., Khalil R.A. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem. Pharmacol. 2009, 78(6):539-552.
37. Taniyama Y., Griendling K.K. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 2003, 42(6):1075-1081.
38. Touyz R.M. Reactive oxygen species and angiotensin II signaling in vascular cells-implications in cardiovascular disease. Braz. J. Med. Biol. Res. 2004, 37(8):1263-1273.
39. Touyz R.M. Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries. Arterioscler. Thromb. Vasc. Biol. 2006, 26(4):685-688.
40. Touyz R.M., Tabet F., Schiffrin E.L. Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clin. Exp. Pharmacol. Physiol. 2003, 30(11):860-866.
41. Ungvari Z., Csiszar A., Huang A., Kaminski P.M., Wolin M.S., Koller A. High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase. Circulation 2003, 108(10):1253-1258.
42. Virdis A., Neves M.F., Amiri F., Viel E., Touyz R.M., Schiffrin E.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 2002, 40(4):504-510.
43. Wang D., Chabrashvili T., Wilcox C.S. Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium. Circ. Res. 2004, 94(11):1436-1442.
44. Wei Y., Whaley-Connell A.T., Chen K., Habibi J., Uptergrove G.M., Clark S.E., Stump C.S., Ferrario C.M., Sowers J.R. NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat. Hypertension 2007, 50(2):384-391.