Lipodystrophy during pegvisomant therapy: A case report and review of the literature

Clinics

Volumn 65, Issue 9, 2010, Pages 931-933

  Buyuktas, D ^a   Celik, O ^a   Kantarci, F ^a   Kadioglu, P ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; HUMAN GROWTH HORMONE; PEGVISOMANT;

ACROMEGALY; CASE REPORT; CHEMICALLY INDUCED DISORDER; FEMALE; HUMAN; LETTER; LIPODYSTROPHY; MIDDLE AGED;

ACROMEGALY; FEMALE; HUMAN GROWTH HORMONE; HUMANS; LIPODYSTROPHY; MIDDLE AGED;

EID: 78249252704     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322010000900018     Document Type: Letter

References (8)

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2. Kopchick JJ, Parkinson C, Stevens EC, Trainer PJ. Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocrin Reviews. 2002; 23: 623-46, doi: 10.1210/er.2001-0022.
3. van der Lely AJ, Hutson RK, Trainer PJ, Besser GM, Barkan Al, Katznelson L, et al. Lon-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet. 2001; 358: 1754-9, doi: 10.1016/S0140-6736(01)06844-1.
4. Mersebach H, Feldt-Ramussen UF. Localized lipohypertrophy during growth hormone therapy. Ugeskr Laeger. 2002; 164:1930-2.
5. Maffei P, Martini C, Pagano C, Sicolo N, Corbetti F. Lipohypertrophy in acromegaly induced by the new growth hormone receptor antagonist pegvisomant. Annals of Internal Medicine. 2006; 145:310-2.
6. Salvatore C, Giovanni R, Vittorio C, Claudia S, Patrizia CS. Subcutaneous lipoatrophy induced by long-term pegvisomant administration. Clinical Endocrinology (Oxf). 2009; 70: 655-6, doi: 10.1111/j.1365-2265.2008.03400.x.
7. Marazuela M, Dauden E, Ocon E, Moure D, Nattero L. Pegvisomant induced lipohypertrophy: report of a case with histopathology. Annals of Internal Medicine. 2007; 147:741-3.
8. Bonert VS, Kennedy L, Petersenn S, Barkan A, Carmichael J, Melmed S. Lipodystrophy in patients with acromegaly receiving pegvisomant. Journal of Clinical Endocrinology & Metabolism. 2008; 93:3515-8, doi: 10.1210/jc.2008-0833.