Lipohypertrophy in acromegaly induced by the new growth hormone receptor antagonist pegvisomant [3]

Annals of Internal Medicine

Volumn 145, Issue 4, 2006, Pages 310-312

  Maffei, Pietro ^a   Martini, Chiara ^a   Pagano, Claudio ^a   Sicolo, Nicola ^a   Corbetti, Francesco ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LIVER ENZYME; PEGVISOMANT; SOMATOMEDIN C; DRUG DERIVATIVE; HUMAN GROWTH HORMONE;

ABDOMINAL DISTENSION; ACROMEGALY; ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; CASE REPORT; CLINICAL EXAMINATION; CLINICAL FEATURE; DRUG EFFICACY; ECHOGRAPHY; FEMALE; HUMAN; LETTER; LIPOHYPERTROPHY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ABDOMEN; CHEMICALLY INDUCED DISORDER; HYPERTROPHY; LIPODYSTROPHY; PATHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION;

ABDOMEN; ACROMEGALY; ADIPOSE TISSUE; ADULT; FEMALE; HUMAN GROWTH HORMONE; HUMANS; HYPERTROPHY; INJECTIONS, SUBCUTANEOUS; LIPODYSTROPHY; MALE;

EID: 33747100659     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-145-4-200608150-00017     Document Type: Letter

References (5)

1. Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000;342:1171-7.
2. van der Lely AJ, Hutson RK, Trainer PJ, Besser GM, Barkan AL, Katznelson L, et al. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet. 2001;358:1754-9.
3. Kopchick JJ, Parkinson C, Stevens EC, Trainer PJ. Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocr Rev. 2002;23:623-46.
4. Trainer PJ, Drake WM, Perry LA, Taylor NF, Besser GM, Monson JP. Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly. J Clin Endocrinol Metab. 2001;86:2989-92.
5. Muller AF, Kopchick JJ, Flyvbjerg A, van der Lely AJ. Clinical review 166: Growth hormone receptor antagonists. J Clin Endocrinol Metab. 2004;89:1503-11.