Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

FEBS Letters

Volumn 584, Issue 22, 2010, Pages 4505-4510

  Bae, Yoonhee ^a   Choi, Dongwon ^a   Rhim, Hyangshuk ^b   Kang, Seongman ^a  

^a Korea University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; Cyclin B1; Hip2; Ubiquitination

Indexed keywords

CYCLIN B1; PROTEIN HIP2; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS;

APOPTOSIS; CYCLIN B1; HCT116 CELLS; HEK293 CELLS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STABILITY; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

EID: 78249251470     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.10.016     Document Type: Article

References (20)

1. Kalchman M.A., et al. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J. Biol. Chem. 1996, 271:19385-19394.
2. Song S., et al. Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. Mol. Cell 2003, 12:553-563.
3. Lee S.J., Choi J.Y., Sung Y.M., Park H., Rhim H., Kang S. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. FEBS Lett. 2001, 503:61-64.
4. Rodrigo-Brenni M.C., Morgan D.O. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 2007, 130:127-139.
5. Mastrandrea L.D., Kasperek E.M., Niles E.G., Pickart C.M. Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K. Biochemistry 1998, 37:9784-9792.
6. Knecht E., et al. Intracellular protein degradation in mammalian cells: recent developments. Cell. Mol. Life Sci. 2009, 66:2427-2443.
7. Li W., Tu D.Q., Brunger A.T., Ye Y.H. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Nature 2007, 446:333-337.
8. Hoeller D., Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009, 458:438-444.
9. Hochstrasser M. Protein degradation or regulation: Ub the judge. Cell 1996, 84:813-815.
10. Cogswell J.P., Godlevski M.M., Bonham M., Bisi J., Babiss L. Upstream stimulatory factor regulates expression of cell cycle-dependent cyclin B1 gene promoter. Mol. Cell. Biol. 1995, 15:2782-2790.
11. Pines J., Hunter T. Human cyclin-A and cyclin-B1 are differentially located in the cell and undergo cell cycle-depenent nuclear transport. J. Cell Biol. 1991, 115:1-17.
12. Clute P., Pines J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat. Cell Biol. 1999, 1:82-87.
13. Hershko A. Mechanisms and regulation of the degradation of cyclin B. Philos. Trans. R Soc. Lond. B Biol. Sci. 1999, 354:1571-1575.
14. Zhang S.M., Sun Y., Fan R., Xu Q.Z., Liu X.D., Zhang X.M., Wang Y., Zhou P.K. HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation. FASEB J. 2010, 24:495-503.
15. Gomez L.A., de las Pozas A., Reiner T., Burnstein K., Perez-Stable C. Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy. Mol. Cancer Ther. 2007, 6:1534-1543.
16. Bae Y., Kho C.W., Lee S.Y., Rhim H., Kang S. Hip2 interacts with and destabilizes Smac/DIABLO. Biochem. Biophys. Res. Commun. 2010, 397:718-723.
17. Bassermann F., Peschel C., Duyster J. Mitotic entry-A matter of oscillating destruction. Cell Cycle 2005, 4:1515-1517.
18. Porter L.A., Singh G., Lee J.M. Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis. Blood 2000, 95:2645-2650.
19. van Engeland M., Nieland L.J.W., Ramaekers F.C.S., Schutte B., Reutelingsperger C.P.M. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 1998, 31:1-9.
20. Chen Z.J., Pickart C.M. A 25-kilodaton ubiquitn carrier protein (E2) catalyzes multiubiqutin chain synthesis via lysine-48 of ubiquitin. J. Biol. Chem. 1990, 265:21835-21842.