Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain

FEBS Letters

Volumn 584, Issue 22, 2010, Pages 4500-4504

  Arai, Munehito ^a,b,c   Dyson, H Jane ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Isothermal titration calorimetry; Mixed lineage leukemia; NMR chemical shift perturbation; Protein protein interaction; Transactivation domain; Transcriptional coacvitator CBP

Indexed keywords

ALANINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LEUCINE; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN C MYB;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

ANIMALS; BINDING SITES; CREB-BINDING PROTEIN; HUMANS; LEUCINE; MICE; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTIONAL ACTIVATION;

EID: 78249237191     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.10.024     Document Type: Article

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