Phospholipid binding improves plasma survival of factor VIII

Thrombosis and Haemostasis

Volumn 104, Issue 5, 2010, Pages 1073-1075

  Pisal, Dipak S ^a   Balu Iyer, Sathy V ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 8; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID BINDING PROTEIN; VON WILLEBRAND FACTOR;

AREA UNDER THE CURVE; BLOOD CLOTTING FACTOR DEFICIENCY; HEMOPHILIA A; LETTER; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; THROMBOCYTE MEMBRANE;

ANIMALS; AREA UNDER CURVE; COAGULANTS; DISEASE MODELS, ANIMAL; FACTOR VIII; HALF-LIFE; HEMOPHILIA A; METABOLIC CLEARANCE RATE; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPIDS; VON WILLEBRAND FACTOR;

EID: 78149482075     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-06-0422     Document Type: Letter

References (23)

1. Klinge J, Ananyeva NM, Hauser CA, et al. Hemophilia A - from basic science to clinical practice. Semin Thromb Hemost 2002; 28: 309-322.
2. Lenting PJ, CJ VANS, Denis CV. Clearance mechanisms of von Willebrand factor and factor VIII. J Thromb Haemost 2007; 5: 1353-1360.
3. Saenko EL, Scandella D. The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor. J Biol Chem 1997; 272: 18007-18014.
4. Saenko EL, Shima M, Rajalakshmi KJ, et al. A role for the C2 domain of factor VIII in binding to von Willebrand factor. J Biol Chem 1994; 269: 11601-11605.
5. Lenting PJ, Neels JG, van den Berg BM, et al. The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein. J Biol Chem 1999; 274: 23734-23739.
6. Saenko EL, Yakhyaev AV, Mikhailenko I, et al. Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism. J Biol Chem 1999; 274: 37685-37692.
7. Gilbert GE, Kaufman RJ, Arena AA, et al. Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs. J Biol Chem 2002; 277: 6374-6381.
8. Meems H, Meijer AB, Cullinan DB, et al. Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. Blood 2009; 114: 3938-3946.
9. Hsu TC, Pratt KP, Thompson AR. The factor VIII C1 domain contributes to platelet binding. Blood 2008; 111: 200-208.
10. Kemball-Cook G, Barrowcliffe TW. Interaction of factor VIII with phospholipids: role of composition and negative charge. Thromb Res 1992; 67: 57-71.
11. Ramani K, Miclea RD, Purohit VS, et al. Phosphatidylserine containing liposomes reduce immunogenicity of recombinant human factor VIII (rFVIII) in a murine model of hemophilia A. J Pharm Sci 2008; 97: 1386-1398.
12. Purohit VS, Ramani K, Sarkar R, et al. Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex. J Biol Chem 2005; 280: 17593-17600.
13. Berntorp E, Bjorkman S. The pharmacokinetics of clotting factor therapy. Haemophilia 2003; 9: 353-359.
14. Barrowcliffe TW, Raut S, Sands D, et al. Coagulation and chromogenic assays of factor VIII activity: general aspects, standardization, and recommendations. Semin Thromb Hemost 2002; 28: 247-256.
15. Nedelman JR, Gibiansky E, Lau DT. Applying Bailer's method for AUC confidence intervals to sparse sampling. Pharm Res 1995; 12: 124-128.
16. Bovenschen N, Mertens K, Hu L, et al. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 2005; 106: 906-912.
17. Saenko E, Kannicht C, Loster K, et al. Development and applications of surface plasmon resonance-based von Willebrand factor-collagen binding assay. Anal Biochem 2002; 302: 252-262.
18. Saenko E, Sarafanov A, Greco N, et al. Use of surface plasmon resonance for studies of protein-protein and protein-phospholipid membrane interactions. Application to the binding of factor VIII to von Willebrand factor and to phosphatidylserine-containing membranes. J Chromatogr A 1999; 852: 59-71.
19. Kamps JA, Scherphof GL. Receptor versus non-receptor mediated clearance of liposomes. Adv Drug Deliv Rev 1998; 32: 81-97.
20. Denis CV, Christophe OD, Oortwijn BD, et al. Clearance of von Willebrand factor. Thromb Haemost 2008; 99: 271-278.
21. Gabizon A, Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc Natl Acad Sci USA 1988; 85: 6949-6953.
22. Ngo JC, Huang M, Roth DA, et al. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure 2008; 16: 597-606.
23. Pratt KP, Shen BW, Takeshima K, et al. Structure of the C2 domain of human factor VIII at 1.5 A resolution. Nature 1999; 402: 439-442.