Identification of tumor-associated antigens from medullary breast carcinoma by a modified SEREX approach

Molecular Biotechnology

Volumn 46, Issue 2, 2010, Pages 105-112

  Kiyamova, Ramziya ^a   Kostianets, Olga ^a   Malyuchik, Sergey ^a   Filonenko, Valeriy ^a   Usenko, Vasiliy ^b   Gurtovyy, Vadym ^b   Khozayenko, Yuliya ^b   Antonuk, Stepan ^c   Old, Lloyd ^d   Gout, Ivan ^a,e  

^a INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

^b Medical Technologies   (Ukraine)

^c Dnipropetrovsk Municipal Clinical Hospital   (Ukraine)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer immunotherapy and diagnostics; CDNA expression library; Medullary breast carcinoma; SEREX; Tumor associated antigens

Indexed keywords

BREAST CANCER; BREAST CARCINOMAS; CANCER IMMUNOTHERAPY; CDNA CLONES; CDNA EXPRESSION LIBRARY; FALSE POSITIVE; IMMUNE RESPONSE; IMMUNOGLOBULIN GENES; MEDULLARY BREAST CARCINOMA; MITOTIC INDEX; SEREX; TUMOR ANTIGEN; TUMOR SAMPLES;

SEEPAGE; SOIL MECHANICS; TUMORS;

ANTIGENS;

COMPLEMENTARY DNA; IMMUNOGLOBULIN G; TUMOR ANTIGEN;

ADULT; AGED; ANTIGEN DETECTION; ANTIGEN PURIFICATION; ARTICLE; BREAST CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA LIBRARY; FEMALE; HUMAN; HUMAN TISSUE; MEDULLARY CARCINOMA; METHODOLOGY; MOLECULAR CLONING; PROTEIN EXPRESSION;

ANTIGENS, NEOPLASM; BREAST NEOPLASMS; CARCINOMA, MEDULLARY; DNA, COMPLEMENTARY; FEMALE; GENE LIBRARY; HUMANS; IMMUNE SERA;

EID: 78149467817     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-010-9285-2     Document Type: Article

References (14)

1. Finn, O. J. (2008). Cancer immunology. New England Journal of Medicine, 358, 2704-2715.
2. Mattes, M. J., Look, K., Furukawa, K., Pierce, V. K., Old, L. J., Lewis, J. L., et al. (1987). Mouse monoclonal antibodies to human epithelial differentiation antigens expressed on the surface of ovarian carcinoma ascites cells. Cancer Research, 47, 6741-6750.
3. Boon, T., Couli, P. G., & Van den Eynde, B. (1997). Tumor antigens recognized by T cells. Immunology Today, 18, 267-268.
4. Boon, T. (1993). Tumor antigens recognized by cytolytic T lymphocytes: present perspectives for specific immunotherapy. International Journal of Cancer, 54, 177-180.
5. Parkhurst, M. R., Fitzgerald, E. B., Southwood, S., Sette, A., Rosenberg, S. A., & Kawakami, Y. (1998). Identification of a shared HLA by A0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2). Cancer Research, 58, 4895-4901.
6. Wang, R. F., Wang, X., Atwood, A. C., Topalian, S. L., & Rosenberg, S. A. (1999). Cloning genes encoding MHC class IIrestricted antigens: mutated CDC27 as a tumor antigen. Science, 284, 1351-1354.
7. Gunawardana, C. G., & Diamandis, E. P. (2007). High throughput proteomic strategies for identifying tumour-associated antigens. Cancer Letters, 249, 110-119.
8. Sahin, U., Tureci, O., & Pfreundschuh, M. (1997). Serological identification of human tumor antigens. Current Opinion Immunology, 9, 709-716.
9. Old, L. J. (2008). Cancer vaccines: An overview. Cancer Immunity, 8(Suppl 1), 1.
10. Ridolfi, R. L., Rosen, P. P., Port, A., Kinne, D., & Mike, V. (1977). Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up. Cancer, 40, 1365-1385.
11. Kuroda, H., Tamaru, J., Sakamoto, G., Ohnisi, K., & Itoyama, S. (2005). Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast. Virchows Archiv, 446, 10-14.
12. Hansen, M. H., Nielsen, H. V., & Ditzel, H. J. (2002). Translocation of an intracellular antigen to the surface of medullary breast cancer cells early in apoptosis allows for an antigen-driven antibody response elicited by tumor-infiltrating B cells. Journal of Immunology, 169, 2701-2711.
13. Kotlan, B., Simsa, P., Teillaud, J. L., Fridman, W. H., Toth, J., McKnight, M., et al. (2005). Novel ganglioside antigen identified by B cells in human medullary breast carcinomas: the proof of principle concerning the tumor-infiltrating B lymphocytes. Journal of Immunology, 175, 2278-2285.
14. Hansen, M. H., Nielsen, H., & Ditzel, H. J. (2001). The tumorinfiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells. Proceedings of the National Academy of Science, 98, 12659-12664.