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1
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Prediction of progression of radiographic damage over 4 years in patients with ankylosing spondylitis [abstract]
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van der Heijde DM, Wanders A, Mielants H, et al.: Prediction of progression of radiographic damage over 4 years in patients with ankylosing spondylitis [abstract]. Ann Rheum Dis 2004, 63: OP132.
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58249103888
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Inflammatory lesions of the spine on MRI predict the development of new syndesmophytes in ankylosing spondylitis: Evidence for coupling between inflammation and ankylosis
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Maksymowych WP, Chiowchanwisawakit P, Clare T, et al.: Inflammatory lesions of the spine on MRI predict the development of new syndesmophytes in ankylosing spondylitis: evidence for coupling between inflammation and ankylosis. Arthritis Rheum 2009, 60:93-102.
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Maksymowych, W.P.1
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66149125235
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Effectiveness, safety, and predictors of good clinical response in 1250 patients treated with adalimumab for active ankylosing spondylitis
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This was a large, open-label analysis of the efficacy and safety of adalimumab in real world practice that also examined clinical and laboratory parameters used in routine care as predictors of treatment response
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•• Rudwaleit M, Claudepierre P, Wordsworth P, et al.: Effectiveness, safety, and predictors of good clinical response in 1250 patients treated with adalimumab for active ankylosing spondylitis. J Rheumatol 2009, 36:801-808. This was a large, open-label analysis of the efficacy and safety of adalimumab in real world practice that also examined clinical and laboratory parameters used in routine care as predictors of treatment response.
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J Rheumatol
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Rudwaleit, M.1
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Prediction of a major clinical response (BASDAI 50) to tumor necrosis factor a blockers in ankylosing spondylitis
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Rudwaleit M, Listing J, Brandt J, et al.: Prediction of a major clinical response (BASDAI 50) to tumor necrosis factor a blockers in ankylosing spondylitis. Ann Rheum Dis 2004, 63:665-670.
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Ann Rheum Dis
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Rudwaleit, M.1
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Brandt, J.3
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5
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50249188382
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MRI in predicting a major clinical response to anti-tumor necrosis factor treatment in ankylosing spondylitis
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This is one of the few studies that has incorporated MRI data for inflammation into a prediction model for treatment response
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• RudwaleitM, Schwarzlose S, Hilgert ES, et al.:MRI in predicting a major clinical response to anti-tumor necrosis factor treatment in ankylosing spondylitis. Ann Rheum Dis 2008, 67:1276-1281. This is one of the few studies that has incorporated MRI data for inflammation into a prediction model for treatment response.
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Ann Rheum Dis
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Rudwaleit, M.1
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Efficacy and safety of adalimumab in patients with ankylosing spondylitis: Results of a multicenter, randomized, double-blind, placebo-controlled trial
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van der Heijde D, Kivitz A, Schiff MH, et al.: Efficacy and safety of adalimumab in patients with ankylosing spondylitis: results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2006, 54:2136-2146.
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Van Der Heijde, D.1
Kivitz, A.2
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7
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Quantitative analyses of sacroiliac biopsies in spondylarthropathies: T cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancement detected by magnetic resonance imaging
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Bollow M, Fischer T, Reisshauer H, et al.: Quantitative analyses of sacroiliac biopsies in spondylarthropathies: T cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancement detected by magnetic resonance imaging. Ann Rheum Dis 2000, 59:135-140.
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8
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Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
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Appel H, Loddenkemper C, Grozdanovic Z, et al.: Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther 2006, 8:R143.
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Arthritis Res Ther
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Appel, H.1
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9
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Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis
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Lambert RGW, Salonen D, Rahman P, et al.: Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis. Arthritis Rheum 2007, 56:4005-4014.
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Rgw, L.1
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10
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Serum amyloid a as a useful indicator of disease activity in patients with ankylosing spondylitis
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Jung SY, Park MC, Park YB, Lee SK: Serum amyloid a as a useful indicator of disease activity in patients with ankylosing spondylitis. Yonsei Med J 2007, 48:218-224.
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Jung, S.Y.1
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11
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Comparison of a high sensitivity and standard C reactive protein measurement in patients with ankylosing spondylitis and nonradiographic axial spondyloarthritis
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Poddubnyy DA, Rudwaleit M, Listing J, et al.: Comparison of a high sensitivity and standard C reactive protein measurement in patients with ankylosing spondylitis and nonradiographic axial spondyloarthritis. Ann Rheum Dis 2010, 69:1338-1341.
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Poddubnyy, D.A.1
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12
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33845875436
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Comparison of serum IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in ankylosing spondylitis
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Bal A, Unlu E, Bahar G, et al.: Comparison of serum IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in ankylosing spondylitis. Clin Rheumatol 2007, 26:211-215.
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Clin Rheumatol
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Bal, A.1
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Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: A brief report and literature review
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Keller C, Webb A, Davis J: Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review. Ann Rheum Dis 2003, 62:1128-1132.
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Keller, C.1
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Davis, J.3
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14
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41849120865
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Inflammatory biomarkers, disease activity and spinal disease measures in patients with ankylosing spondylitis after treatment with infliximab
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This is one of the larger studies in the field and includes a multivariate analysis of cytokines and other biomarkers as predictors of treatment response. The latter is defined according to both MRI and clinical parameters of inflammation
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• Visvanathan S, Wagner C, Marini JC, et al.: Inflammatory biomarkers, disease activity and spinal disease measures in patients with ankylosing spondylitis after treatment with infliximab. Ann Rheum Dis 2008, 67:511-517. This is one of the larger studies in the field and includes a multivariate analysis of cytokines and other biomarkers as predictors of treatment response. The latter is defined according to both MRI and clinical parameters of inflammation.
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Ann Rheum Dis
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Visvanathan, S.1
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Marini, J.C.3
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15
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77949444874
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Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
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This study compared synovial and peripheral blood expression of IL-17/ 23 in RA, psoriatic arthritis, and SpA. Cytokines are examined for their associations with disease activity
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• Melis L, Vandooren B, Kruithof E, et al.: Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis. Ann Rheum Dis 2010, 69:618-623. This study compared synovial and peripheral blood expression of IL-17/ 23 in RA, psoriatic arthritis, and SpA. Cytokines are examined for their associations with disease activity.
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Ann Rheum Dis
, vol.69
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Melis, L.1
Vandooren, B.2
Kruithof, E.3
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16
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58149197788
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Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients
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Wendling D, Cedoz JP, Racadot E: Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients. Clin Rheumatol 2009, 28:187-190.
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Wendling, D.1
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17
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55849134446
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Identification of interleukin- 7 as a candidate disease mediator in spondylarthritis
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Rihl M, Kellner H, Kellner W, et al.: Identification of interleukin- 7 as a candidate disease mediator in spondylarthritis, Arthritis Rheum 2008, 58:3430-3435.
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Rihl, M.1
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73449131201
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From gene expression to serum proteins: Biomarker discovery in ankylosing spondylitis
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Haroon N, Tsui FWL, O'Shea FD, et al.: From gene expression to serum proteins: biomarker discovery in ankylosing spondylitis. Ann Rheum Dis 2010, 69:297-300.
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Haroon, N.1
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19
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Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis
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Maksymowych WP, Landewé R, Conner-Spady B, et al.: Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis. Arthritis Rheum 2007, 56:1846-1853.
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Arthritis Rheum
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Maksymowych, W.P.1
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20
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54949093957
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Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis
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This report describes the associations between several biomarkers and disease activity in a placebo-controlled trial of adalimumab in AS. Disease activity is assessed according to clinical, laboratory, and MRI parameters
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• Maksymowych WP, Rahman P, Shojania K, et al.: Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis. J Rheumatol 2008, 35:2030-2037. This report describes the associations between several biomarkers and disease activity in a placebo-controlled trial of adalimumab in AS. Disease activity is assessed according to clinical, laboratory, and MRI parameters.
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J Rheumatol
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, pp. 2030-2037
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Maksymowych, W.P.1
Rahman, P.2
Shojania, K.3
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21
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34547943895
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Changes of clinical response and bone biochemical markers in patients with ankylosing spondylitis taking etanercept
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Woo JH, Lee HJ, Sung IH, Kim TH: Changes of clinical response and bone biochemical markers in patients with ankylosing spondylitis taking etanercept. J Rheumatol 2007, 34:1753-1759.
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J Rheumatol
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Woo, J.H.1
Lee, H.J.2
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Kim, T.H.4
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22
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56049091470
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Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment
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This is one of the few studies comparing biomarker levels over time in patients on standard therapy and those receiving a TNF blocker
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• Appel H, Janssen L, Listing J, et al.: Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment. Arthritis Res Ther 2008, 10:R125. This is one of the few studies comparing biomarker levels over time in patients on standard therapy and those receiving a TNF blocker.
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Arthritis Res Ther
, vol.10
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Appel, H.1
Janssen, L.2
Listing, J.3
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23
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Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy
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Vandooren B, Kruithof E, Yu DT, et al.: Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. Arthritis Rheum 2004, 50:2942-2953.
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26444474599
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Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis
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Maksymowych WP, Poole AR, Hiebert L, et al.: Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis. J Rheumatol 2005, 32:1911-1917.
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Maksymowych, W.P.1
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14944375911
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Cartilage biomarkers in ankylosing spondylitis: Relationship to clinical variables and treatment response
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Kim TH, Stone M, Payne U, et al.: Cartilage biomarkers in ankylosing spondylitis: relationship to clinical variables and treatment response. Arthritis Rheum 2005, 52:885-891.
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Kim, T.H.1
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26
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47849103048
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Association of markers of bone- and cartilage-degradation with radiological changes at baseline and after 2 years follow-up in patients with ankylosing spondylitis
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This prospective study examined biomarkers of cartilage turnover in a multivariate analysis of AS patients on standard therapies to determine their ability to predict joint damage
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• Vosse D, Landewé R, Garnero P, et al.: Association of markers of bone- and cartilage-degradation with radiological changes at baseline and after 2 years follow-up in patients with ankylosing spondylitis. Rheumatology (Oxford) 2008, 47:1219-1222. This prospective study examined biomarkers of cartilage turnover in a multivariate analysis of AS patients on standard therapies to determine their ability to predict joint damage.
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Rheumatology (Oxford)
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Relationship between urinary pyridinium crosslinks, disease activity and disease subsets of ankylosing spondylitis
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Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis
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Franck H, Meurer T, Hofbauer LC: Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis. J Rheumatol 2004, 31:2236-2241.
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Effects of infliximab on markers of inflammation and bone turnover and associations with bone mineral density in patients with ankylosing spondylitis
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Visvanathan S, van der Heijde D, Deodhar A, et al.: Effects of infliximab on markers of inflammation and bone turnover and associations with bone mineral density in patients with ankylosing spondylitis. Ann Rheum Dis 2009, 68:175-182.
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39549123007
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Toussirot E, Dumoulin G, Saas P, et al.: Increased tartrate-resistant acid phosphatase serum levels in ankylosing spondylitis and relationship with the inflammatory process. Ann Rheum Dis 2008, 67:430-431.
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Vis M, Havaardsholm EA, Haugeberg G, et al.: Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NF kappa B ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis. Ann Rheum Dis 2006, 65:1495-1499.
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DKK-1 levels are comparably increased in patients with AS and RA, show similar decreases with anti-TNF therapy, and are not associated with markers of bone remodeling [abstract]
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Wang N, Morrow S, Mallon C, Maksymowych WP: DKK-1 levels are comparably increased in patients with AS and RA, show similar decreases with anti-TNF therapy, and are not associated with markers of bone remodeling [abstract]. Ann. Rheum Dis 2008, 67(Suppl II):129.
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74849091356
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Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis
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In Contrast to the Diarra et Al. Report [34], This Study Reported Higher Levels of DKK-1 in AS but Also Provided Evidence That DKK-1 May Be Dysfunctional. Furthermore, It Showed That This May Be An Important Factor in Driving New Bone Formation Through Inhibition of Signalling Through Wingless Proteins
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• Daoussis D, Liossis SN, Solomou EE, et al.: Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis. Arthritis Rheum 2010, 62:150-158. In contrast to the Diarra et al. report [34], this study reported higher levels of DKK-1 in AS but also provided evidence that DKK-1 may be dysfunctional. Furthermore, it showed that this may be an important factor in driving new bone formation through inhibition of signalling through wingless proteins.
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Arthritis Rheum
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Daoussis, D.1
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Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis
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Choi ST, Kim JH, Kang EJ, et al.: Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis. Rheumatology (Oxford) 2008, 47:1775-1779.
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Choi, S.T.1
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Kang, E.J.3
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39
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68949149643
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Increased production of soluble CTLA-4 in patients with spondyloarthropathies correlates with disease activity
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This study reported for the first time that a biomarker reflecting regulation of T-cell costimulation may reflect disease activity in SpA
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•• Toussirot E, Saas P, Deschamps M, et al.: Increased production of soluble CTLA-4 in patients with spondyloarthropathies correlates with disease activity. Arthritis Res Ther 2009, 11: R101. This study reported for the first time that a biomarker reflecting regulation of T-cell costimulation may reflect disease activity in SpA.
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Arthritis Res Ther
, vol.11
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Toussirot, E.1
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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): A new mediator involved in early ankylosing spondylitis
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Chen CH, Liao HT, Chen HA, et al.: Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a new mediator involved in early ankylosing spondylitis. J Rheumatol 2008, 35:1846-1848.
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J Rheumatol
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Chen, C.H.1
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Chen, H.A.3
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41
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78149468542
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A prediction model for future radiologic damage in ankylosing spondylitis based on a prospective cohort analysis [abstract]
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O'Shea FD, Haroon N, Riarh R, Inman RD: A prediction model for future radiologic damage in ankylosing spondylitis based on a prospective cohort analysis [abstract]. Arthritis Rheum 2009, 60 (Suppl):1797.
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Arthritis Rheum
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O'shea, F.D.1
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42
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78149466855
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Multiplex assay of a panel of 58 biomarkers in ankylosing spondylitis: Identification of high priority candidates for prediction of structural damage [abstract]
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MaksymowychWP, Morency N,Wichuk S, et al.:Multiplex assay of a panel of 58 biomarkers in ankylosing spondylitis: identification of high priority candidates for prediction of structural damage [abstract]. Ann Rheum Dis 2010, 69(Suppl 3):428.
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Ann Rheum Dis
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Maksymowych, W.P.1
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78149466191
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The relationship of biomarkers and radiographic progression in patients with ankylosing spondylitis treated with TNF-blockers [abstract]
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Baraliakos X, Landewe RB, van der Heijde D, et al.: The relationship of biomarkers and radiographic progression in patients with ankylosing spondylitis treated with TNF-blockers [abstract]. Ann Rheum Dis 2010, 69(Suppl 3):105.
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(2010)
Ann Rheum Dis
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Baraliakos, X.1
Landewe, R.B.2
Van Der Heijde, D.3
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44
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78149468179
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Inverse correlation between serum levels of dickkopf 1 (DKK1) and new bone formation in ankylosing spondylitis patients [abstract]
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Sieper J, Appel H, Rudwaleit M, et al.: Inverse correlation between serum levels of dickkopf 1 (DKK1) and new bone formation in ankylosing spondylitis patients [abstract]. Ann Rheum Dis 2010, 69(Suppl 3):442.
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Ann Rheum Dis
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Sieper, J.1
Appel, H.2
Rudwaleit, M.3
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45
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70350558488
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Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis
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This study described the first evaluation of sclerostin as a biomarker for predicting radiographic progression in SpA. It also described the immunohistochemical localization data of this molecule in SpA as compared with RA patients and those with osteoarthritis
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•• Appel H, Ruiz-Heiland G, Listing J, et al.: Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum 2009, 60:3257-3262. This study described the first evaluation of sclerostin as a biomarker for predicting radiographic progression in SpA. It also described the immunohistochemical localization data of this molecule in SpA as compared with RA patients and those with osteoarthritis.
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(2009)
Arthritis Rheum
, vol.60
, pp. 3257-3262
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Appel, H.1
Ruiz-Heiland, G.2
Listing, J.3
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46
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45549083413
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Relationship of bone morphogenetic proteins to disease activity and radiographic damage in patients with ankylosing spondylitis
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Park MC, Park YB, Lee SK: Relationship of bone morphogenetic proteins to disease activity and radiographic damage in patients with ankylosing spondylitis. Scand J Rheumatol 2008, 37:200-204.
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Scand J Rheumatol
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, pp. 200-204
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Park, M.C.1
Park, Y.B.2
Lee, S.K.3
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47
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70449516048
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Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
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This was a large prospective study analyzing clinical and laboratory parameters used in routine care as predictors of treatment response to anti-TNF-a therapy
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• de Vries MK, van Eijk IC, van der Horst-Bruinsma IE, et al.: Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis. Arthritis Rheum 2009, 61:1484-1490. This was a large prospective study analyzing clinical and laboratory parameters used in routine care as predictors of treatment response to anti-TNF-a therapy.
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(2009)
Arthritis Rheum
, vol.61
, pp. 1484-1490
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De Vries, M.K.1
Van Eijk, I.C.2
Van Der Horst-Bruinsma, I.E.3
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48
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35148883476
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C-reactive protein predicts tumor necrosis factor-alpha blocker retention rate in axial ankylosing spondylitis
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Luc M, Gossec L, Ruyssen-Witrand A, et al.: C-reactive protein predicts tumor necrosis factor-alpha blocker retention rate in axial ankylosing spondylitis. J Rheumatol 2007, 34:2078-2081.
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(2007)
J Rheumatol
, vol.34
, pp. 2078-2081
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Luc, M.1
Gossec, L.2
Ruyssen-Witrand, A.3
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49
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53849090620
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Identification of acute phase reactants and cytokines useful for monitoring infliximab therapy in ankylosing spondylitis
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Romero-Sánchez C, Robinson WH, Tomooka BH, et al.: Identification of acute phase reactants and cytokines useful for monitoring infliximab therapy in ankylosing spondylitis. Clin Rheumatol 2008, 27:1429-1435.
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(2008)
Clin Rheumatol
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, pp. 1429-1435
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Romero-Sánchez, C.1
Robinson, W.H.2
Tomooka, B.H.3
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50
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0346690017
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Cytokine correlates of clinical response patterns to infliximab treatment of ankylosing spondylitis
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Stone MA, Payne U, Pacheco-Tena C, Inman RD: Cytokine correlates of clinical response patterns to infliximab treatment of ankylosing spondylitis. Ann Rheum Dis 2004, 63:84-87.
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(2004)
Ann Rheum Dis
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Stone, M.A.1
Payne, U.2
Pacheco-Tena, C.3
Inman, R.D.4
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