Treating viral exacerbations of chronic obstructive pulmonary disease: Insights from a mouse model of cigarette smoke and H1N1 influenza infection

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Bauer, Carla M T ^a   Zavitz, Caleb C J ^b   Botelho, Fernando M ^b   Lambert, Kristen N ^a   Brown, Earl G ^c   Mossman, Karen L ^a,b   Taylor, John D ^d   Stämpfli, Martin R ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CIGARETTE SMOKE; DEXAMETHASONE; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERFERON; KC PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PIOGLITAZONE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DRUG EFFICACY; DRUG RESPONSE; FEMALE; INFLUENZA A (H1N1); LUNG LAVAGE; MOUSE; NEUTROPHILIA; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG POTENTIATION; HUMAN; INFLUENZA; INFLUENZA VIRUS A H1N1; ISOLATION AND PURIFICATION; METABOLISM; PATHOPHYSIOLOGY; SMOKING; VIROLOGY;

ANIMALIA; INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE; RHINOVIRUS;

ANIMALS; CHEMOKINES; DISEASE MODELS, ANIMAL; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED C57BL; PPAR GAMMA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; THIAZOLIDINEDIONES;

EID: 78149454651     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013251     Document Type: Article

References (44)

1. Rodriguez-Roisin R (2000) Toward a consensus definition for COPD exacerbations. Chest 117: 398S-401S.
2. Wesseling G (2007) Occasional review: influenza in COPD: pathogenesis, prevention, and treatment. Int J Chron Obstruct Pulmon Dis 2: 5-10.
3. Mannino DM, Buist AS (2007) Global burden of COPD: risk factors, prevalence, and future trends. Lancet 370: 765-773.
4. Wedzicha JA (2001) Airway infection accelerates decline of lung function in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164: 1757-1758.
5. Mallia P, Johnston SL (2005) Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations. Proc Am Thorac Soc 2: 361-366; discussion 371-362.
6. Vlahos R, Bozinovski S, Gualano RC, Ernst M, Anderson GP (2006) Modelling COPD in mice. Pulm Pharmacol Ther 19: 12-17.
7. Wright JL, Churg A (2002) Animal models of cigarette smoke-induced COPD. Chest 122: 301S-306S.
8. Niewoehner DE (2006) The Impact of Severe Exacerbations on Quality of Life and the Clinical Course of Chronic Obstructive Pulmonary Disease. The American Journal of Medicine 119: 38.
9. Gorse GJ, O'Connor T Z, Young SL, Habib MP, Wittes J, et al. (2006) Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest 130: 1109-1116.
10. Wongsurakiat P, Maranetra KN, Wasi C, Kositanont U, Dejsomritrutai W, et al. (2004) Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. Chest 125: 2011-2020.
11. Robbins CS, Bauer CM, Vujicic N, Gaschler GJ, Lichty BD, et al. (2006) Cigarette smoke impacts immune inflammatory responses to influenza in mice. Am J Respir Crit Care Med 174: 1342-1351.
12. Gualano RC, Hansen MJ, Vlahos R, Jones JE, Park-Jones RA, et al. (2008) Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice. Respir Res 9: 53.
13. Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, et al. (2008) Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest 118: 2771-2784.
14. Botelho FM, Gaschler GJ, Kianpour S, Zavitz CC, Trimble NJ, et al. (2010) Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice. Am J Respir Cell Mol Biol 42: 394-403.
15. Bauer CM, Zavitz CC, Lambert KN, Brown EG, Mossman KL, et al. (2010) Treating Viral Exacerbations Of COPD With Steroids: Lessons Learned From Animal Models Of Cigarette Smoke Exposure And Influenza A Virus Infection. Am J Respir Crit Care Med 181: A1016.
16. Bauer CM, Zavitz CC, Lambert KN, Brown EG, Mossman KL, et al. (2010) Targeting Peroxisome Proliferator Activated Receptor-Gamma May Be Important For Attenuating Exacerbated Inflammatory Responses To Influenza A Virus In Smoke-Exposed Mice. Am J Respir Crit Care Med 181: A3824.
17. Bauer CM, Zavitz CJ, Brown EG, Mossman KL, Stampfli MR (2009) Cigarette Smoke Exacerbates the Inflammatory Response to Influenza A Infection in Mice Eur Respir J 34: A178.
18. Papi A, Bellettato CM, Braccioni F, Romagnoli M, Casolari P, et al. (2006) Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med 173: 1114-1121.
19. Celli BR, MacNee W (2004) Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 23: 932-946.
20. Gold PM (2009) The 2007 GOLD Guidelines: a comprehensive care framework. Respir Care 54: 1040-1049.
21. Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, et al. (2009) Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile. Am J Respir Crit Care Med 179: 666-675.
22. Roque R, Ponce R, Burleson F, Cabrit M, Broly H, et al. (2006) Influenza virus host response of C57Bl/6 mice treated with TACI-Ig. Immunopharmacol Immunotoxicol 28: 13-32.
23. Xu T, Qiao J, Zhao L, He G, Li K, et al. (2009) Effect of dexamethasone on acute respiratory distress syndrome induced by the H5N1 virus in mice. Eur Respir J 33: 852-860.
24. Aldridge JR, Jr., Moseley CE, Boltz DA, Negovetich NJ, Reynolds C, et al. (2009) TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A 106: 5306-5311.
25. Birrell MA, Patel HJ, McCluskie K, Wong S, Leonard T, et al. (2004) PPARgamma agonists as therapy for diseases involving airway neutrophilia. Eur Respir J 24: 18-23.
26. Sharma R, Kaundal RK, Sharma SS (2009) Amelioration of pulmonary dysfunction and neutrophilic inflammation by PPAR gamma agonist in LPSexposed guinea pigs. Pulm Pharmacol Ther 22: 183-189.
27. Dawson TC, Beck MA, Kuziel WA, Henderson F, Maeda N (2000) Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol 156: 1951-1959.
28. Lin KL, Suzuki Y, Nakano H, Ramsburg E, Gunn MD (2008) CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenzainduced pulmonary immune pathology and mortality. J Immunol 180: 2562-2572.
29. Wedzicha JA, Seemungal TA (2007) COPD exacerbations: defining their cause and prevention. Lancet 370: 786-796.
30. Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8: 183-192.
31. Stampfli MR, Anderson GP (2009) How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol 9: 377-384.
32. Wilt T, Niewoehner D, Kim C-B, Kane R, Linabery A, et al. (2005) Use of Spirometry for Case Finding, Diagnosis, and Management of Chronic Obstructive Pulmonary Disease (COPD). AHRQ Evidence Reports/Technology Assessments. Available: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=erta121. Accessed 2010 Sep 15.
33. Tashkin DP (2010) Preventing and managing exacerbations in COPD-critical appraisal of the role of tiotropium. Int J Chron Obstruct Pulmon Dis 5: 41-53.
34. Xu T, Qiao J, Zhao L, He G, Li K, et al. (2009) Effect of dexamethasone on acute respiratory distress syndrome induced by the H5N1 virus in mice. Eur Respir J 33: 852-860.
35. Hansel TT, Barnes PJ (2009) New drugs for exacerbations of chronic obstructive pulmonary disease. Lancet 374: 744-755.
36. Belvisi MG, Hele DJ (2008) Peroxisome proliferator-activated receptors as novel targets in lung disease. Chest 134: 152-157.
37. Belvisi MG, Mitchell JA (2009) Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease. Br J Pharmacol 158: 994-1003.
38. Liu D, Zeng BX, Zhang SH, Wang YL, Zeng L, et al. (2005) Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, reduces acute lung injury in endotoxemic rats. Crit Care Med 33: 2309-2316.
39. Shah P, Mudaliar S Pioglitazone: side effect and safety profile. Expert Opin Drug Saf 9: 347-354.
40. Drannik AG, Pouladi MA, Robbins CS, Goncharova SI, Kianpour S, et al. (2004) Impact of cigarette smoke on clearance and inflammation after Pseudomonas aeruginosa infection. Am J Respir Crit Care Med 170: 1164-1171.
41. Gaschler GJ, Zavitz CC, Bauer CM, Skrtic M, Lindahl M, et al. (2008) Cigarette smoke exposure attenuates cytokine production by mouse alveolar macrophages. Am J Respir Cell Mol Biol 38: 218-226.
42. Brown EG (1990) Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8. J Virol 64: 4523-4533.
43. Bergner A, Sanderson MJ (2002) Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices. J Gen Physiol 119: 187-198.
44. Khan MA, Kianpour S, Stampfli MR, Janssen LJ (2007) Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema. Eur Respir J 30: 691-700.