Oxygenation state as a driver of myofibroblast differentiation and wound contraction: Hypoxia impairs wound closure

Journal of Investigative Dermatology

Volumn 130, Issue 12, 2010, Pages 2701-2703

  Sen, Chandan K ^a   Roy, Sashwati ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; HUMAN; HYPOXEMIA; MYOFIBROBLAST; NOTE; PRIORITY JOURNAL; SKIN INJURY; TISSUE OXYGENATION; WOUND CLOSURE; WOUND CONTRACTION; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANOXIA; CELL DIFFERENTIATION; HUMANS; MYOFIBROBLASTS; OXYGEN; WOUND HEALING; WOUNDS AND INJURIES;

EID: 78149447023     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.316     Document Type: Note

References (12)

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2. Khanna S, Roy S, Maurer M et al. (2006) Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point. Free Radic Biol Med 40:2147-54
3. Kuhn DE, Roy S, Radtke J et al. (2007) Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes. Am J Physiol Heart Circ Physiol 292:H1245-53
4. Modarressi A, Pietramaggiori G, Godbout C et al. (2010) Hypoxia impairs skin myofibroblast differentiation and function. J Invest Dermatol 130:2818-27
5. Packer L, Fuehr K (1977) Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 267:423-5
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7. Roy S, Khanna S, Wallace WA et al. (2003b) Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart. J Biol Chem 278:47129-35
8. Roy S, Khanna S, Rink T et al. (2007) P21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts. Mol Biol Cell 18:4837-46
9. Roy S, Khanna S, Azad A et al. (2010) Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts. Cardiovasc Res 87:647-55
10. Sen CK (2009) Wound healing essentials: let there be oxygen. Wound Repair Regen 17:1-18
11. Sen CK, Khanna S, Roy S (2006) Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart. Cardiovasc Res 71:280-8
12. Vikatmaa P, Juutilainen V, Kuukasjarvi P et al. (2008) Negative pressure wound therapy: a systematic review on effectiveness and safety. Eur J Vasc Endovasc Surg 36:438-48