Characterization of in vivo keratin 19 phosphorylation on tyrosine-391

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Zhou, Qin ^a   Snider, Natasha T ^b   Liao, Jian ^c   Li, Daniel H ^d   Hong, Anita ^d   Ku, Nam On ^e   Cartwright, Christine A ^a   Bishr Omary, M ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Applied Biomics Inc   (United States)

^d AnaSpec Inc   (United States)

^e Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 19; CYTOKERATIN ANTIBODY; PERVANADATE; PROTEIN TYROSINE KINASE; TYROSINE 391; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION;

MUS; MUS MUSCULUS; ORYCTOLAGUS CUNICULUS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HUMANS; KERATIN-19; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; TYROSINE;

EID: 78149436144     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013538     Document Type: Article

References (35)

1. Fuchs E, Weber K (1994) Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem 63: 345-382.
2. Ku NO, Zhou X, Toivola DM, Omary MB (1999) The cytoskeleton of digestive epithelia in health and disease. Am J Physiol 277: G1108-G1137.
3. Coulombe PA, Omary MB (2002) 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol 14: 110-122.
4. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, et al. (2006) New consensus nomenclature for mammalian keratins. J Cell Biol 174: 169-174.
5. Omary MB, Ku NO, Toivola DM (2002) Keratins: guardians of the liver. Hepatology 35: 251-257.
6. Omary MB, Ku NO, Strnad P, Hanada S (2009) Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest 119: 1794-1805.
7. Bader BL, Magin TM, Hatzfeld M, Franke WW (1986) Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein. EMBO J 5: 1865-1875.
8. Eckert RL (1988) Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin. Proc Natl Acad Sci U S A 85: 1114-1118.
9. Fuchs E, Cleveland DW (1998) A structural scaffolding of intermediate filaments in health and disease. Science 279: 514-519.
10. Porter RM, Lane EB (2003) Phenotypes, genotypes and their contribution to understanding keratin function. Trends Genet 19: 278-285.
11. Uitto J, Richard G, McGrath JA (2007) Diseases of epidermal keratins and their linker proteins. Exp Cell Res 313: 1995-2009.
12. Omary MB (2009) ''IF-pathies'': a broad spectrum of intermediate filamentassociated diseases. J Clin Invest 119: 1756-1762.
13. Omary MB, Coulombe PA, McLean WH (2004) Intermediate filament proteins and their associated diseases. N Engl J Med 351: 2087-2100.
14. Vijayaraj P, Sohl G, Magin TM (2007) Keratin transgenic and knockout mice: functional analysis and validation of disease-causing mutations. Methods Mol Biol 360: 203-251.
15. Marceau N, Schutte B, Gilbert S, Loranger A, Henfling ME, et al. (2007) Dual roles of intermediate filaments in apoptosis. Exp Cell Res 313: 2265-2281.
16. Toivola DM, Strnad P, Habtezion A, Omary MB (2010) Intermediate filaments take the heat as stress proteins. Trends Cell Biol 20: 79-91.
17. Toivola DM, Tao GZ, Habtezion A, Liao J, Omary MB (2005) Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments. Trends Cell Biol 15: 608-617.
18. Inagaki M, Matsuoka Y, Tsujimura K, Ando S, Tokui T, et al. (1996) Dynamic property of intermediate filaments: Regulation by phosphorylation. BioEssays 18: 481-487.
19. Omary MB, Ku NO, Tao GZ, Toivola DM, Liao J (2006) ''Heads and tails'' of intermediate filament phosphorylation: multiple sites and functional insights. Trends Biochem Sci 31: 383-394.
20. Zhou X, Liao J, Hu L, Feng L, Omary MB (1999) Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization. J Biol Chem 274: 12861-12866.
21. Feng L, Zhou X, Liao J, Omary MB (1999) Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinasedependent pathway. J Cell Sci 112 (Pt 13): 2081-2090.
22. Angelastro JM, Ho CL, Frappier T, Liem RK, Greene LA (1998) Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine. J Neurochem 70: 540-549.
23. Valgeirsdottir S, Claesson-Welsh L, Bongcam-Rudloff E, Hellman U, Westermark B, et al. (1998) PDGF induces reorganization of vimentin filaments. J Cell Sci 111 (Pt 14): 1973-1980.
24. Barberis L, Pasquali C, Bertschy-Meier D, Cuccurullo A, Costa C, et al. (2009) Leukocyte transmigration is modulated by chemokine-mediated PI3Kgammadependent phosphorylation of vimentin. Eur J Immunol 39: 1136-1146.
25. Cartwright CA, Eckhart W, Simon S, Kaplan PL (1987) Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain. Cell 49: 83-91.
26. Chou CF, Smith AJ, Omary MB (1992) Characterization and dynamics of Olinked glycosylation of human cytokeratin 8 and 18. J Biol Chem 267: 3901-3906.
27. Ku NO, Toivola DM, Zhou Q, Tao GZ, Zhong B, et al. (2004) Studying simple epithelial keratins in cells and tissues. Methods Cell Biol 78: 489-517.
28. Ku NO, Omary MB (2000) Keratins turn over by ubiquitination in a phosphorylation-modulated fashion. J Cell Biol 149: 547-552.
29. Omary MB, Ku NO, Liao J, Price D (1998) Keratin modifications and solubility properties in epithelial cells and in vitro. Subcell Biochem 31: 105-140.
30. Goldman RD, Grin B, Mendez MG, Kuczmarski ER (2008) Intermediate filaments: versatile building blocks of cell structure. Curr Opin Cell Biol 20: 28-34.
31. Strnad P, Windoffer R, Leube RE (2002) Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases. J Cell Sci 115: 4133-4148.
32. Steinert PM, Wantz ML, Idler WW (1982) O-phosphoserine content of intermediate filament subunits. Biochemistry 21: 177-183.
33. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131: 1190-1203.
34. Kim LC, Song L, Haura EB (2009) Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6: 587-595.
35. Boyer B, Bourgeois Y, Poupon MF (2002) Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene 21: 2347-2356.