Exercise induced - Exercise increases exhaled breath condensate cysteinyl leukotriene concentration in asthmatic patients

Journal of Asthma

Volumn 47, Issue 9, 2010, Pages 1057-1062

  Bikov, András ^a   Gajdócsi, Réka ^b   Huszár, Éva ^b   Szili, Balázs ^a   Lázár, Zsófia ^a   Antus, Balázs ^b   Losonczy, György ^a   Horváth, Ildikó ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL KORANYI INSTITUTE OF PULMONOLOGY   (Hungary)

Author keywords

asthma; cysteinyl leukotrienes; exercise induced bronchoconstriction; exhaled breath condensate; exhaled nitric oxide

Indexed keywords

NITRIC OXIDE; PEPTIDOLEUKOTRIENE; CYSTEINE; CYSTEINYL-LEUKOTRIENE; LEUKOTRIENE;

ADULT; ARTICLE; ASTHMA; ATOPY; BREATHING PATTERN; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FORCED EXPIRATORY VOLUME; HUMAN; INFLAMMATION; LUNG FUNCTION TEST; THERAPY EFFECT; ADOLESCENT; BREATH ANALYSIS; EXERCISE INDUCED ASTHMA; EXERCISE TEST; EXHALATION; FEMALE; MALE; METABOLISM; PATHOPHYSIOLOGY;

ADOLESCENT; ADULT; ASTHMA, EXERCISE-INDUCED; BREATH TESTS; CYSTEINE; EXERCISE TEST; EXHALATION; FEMALE; HUMANS; INFLAMMATION; LEUKOTRIENES; MALE; NITRIC OXIDE; RESPIRATORY FUNCTION TESTS; YOUNG ADULT;

EID: 78149420254     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.1080/02770903.2010.512690     Document Type: Article

References (43)

1. Anderson SD, Charlton B,Weiler JM, Nichols S, Spector SL, Pearlman DS; A305 Study Group. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res 2009; 10:4.
2. Hallstrand TS, Moody MW, Wurfel MM, Swartz LB, Henderson WR, Aitken ML. Inflammatory Basis of Exercise-induced Bronchoconstriction. Am J Respir Crit Care Med 2005; 172:679-686.
3. Buchvald F, Hermansen MN, Nielsen KG, Bisgaard H. Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic school children. Chest 2005; 128:1964-1967.
4. Lex C, Dymek S, Heying R, Kovacevic A, Kramm CM, Schuster A. Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthma. Pediatr Pulmonol 2007; 42:225-230.
5. Malmberg LP, Pelkonen AS, Mattila PS, Hammarén-Malmi S, Mäkelä MJ. Exhaled nitric oxide and exercise-induced bronchoconstriction in young wheezy children-interactions with atopy. Pediatr Allergy Immunol 2009; 20:673-678.
6. ElHalawani SM, Ly NT, Mahon RT, Amundson DE. Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction. Chest 2003; 124:639-643.
7. Scollo M, Zanconato S, Ongaro R, Zaramella C, Zacchello F, Baraldi E. Exhaled nitric oxide and exercise-induced bronchocostriction in asthmatic children. Am J Respir Crit Care Med 2000; 161:1047-1050.
8. Rouhos A, Ekroos H, Karjalainen J, Sarna S, Sovijärvi AR. Exhaled nitric oxide and exercise-induced bronchoconstriction in young male conscripts: association only in atopics. Allergy 2005; 60:1493-1498.
9. Csoma Z, Huszar E, Vizi E, Vass G, Szabó Z, Herjavecz I, Kollai M, Horvath I. Adenosine level in exhaled breath increases during exerciseinduced bronchoconstriction. Eur Respir J 2005; 25:873-878.
10. Balbi B, Pignatti P, Corradi M, Baiardi P, Bianchi L, Brunetti G, Radaeli A, Moscato G, Mutti A, Spanevello A, Malerba M. Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: values in healthy adults. Eur Respir J 2007; 4: 769-781.
11. Horvath I, Hunt J, Barnes PJ. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005; 26:523-548.
12. Carraro S, Corradi M, Zanconato S Alinovi R, Pasquale MF, Zacchello F, Baraldi E. Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction. J Allergy Clin Immunol 2005; 115:764-770.
13. Ratnawati, Morton J, Henry RL, Thomas PS. Mediators in exhaled breath condensate after hypertonic saline challenge. J Asthma 2009; 46:1045-1051.
14. Kullmann T, Barta I, Csiszér E, Antus B, Horvath I. Differential cytokine pattern in the exhaled breath of patients with lung cancer. Pathol Oncol Res 2008; 14:481-483.
15. Vlasić Z, Dodig S, Cepelak I, Topić RZ, Zivcić J, Nogalo B, Turkalj M. Iron and ferritin concentrations in exhaled breath condensate of children with asthma. J Asthma 2009; 46:81-85.
16. Lazar Z, Cervenak L, Orosz M, Galffy G, Komlosi Z, Bikov A, Losonczy G, Horvath I. Adenosine triphosphate concentration of exhaled breath condensate in asthma. Chest 2010; 138:536-542.
17. Hallstrand TS, Henderson WR Jr. Role of leukotrienes in exerciseinduced bronchoconstriction. Curr Allergy Asthma Rep 2009; 9: 18-25.
18. Melo RE, Sole D, Naspitz CK. Exercise-induced bronchoconstriction in children: montelukast attenuates the immediate phase and late phase responses. J Allergy Clin Immunol 2003; 111:301-317.
19. Pajaron-Fernandez M, Garcia-Rubia S, Sanchez-Solis M, Garcia-Marcos L. Montelukast administered in the morning or in the evening to prevent exercise-induced bronchoconstriction in children. Pediatric Pulmonol 2006; 41:222-227.
20. Peroni DG, Piacentini GL, Ress M, Bodini A, Loiacono A, Aralla R, Boner AL. Time efficacy of single dose of montelukast on exerciseinduced asthma in children. Pediatr Allergy Immunol 2002; 13: 434-437.
21. Van Schoor J, Joos GF, Kips JC, Drajesk JF, Carpentier PJ, Pauwels RA. The effect of ABT-761, a novel 5-lipoxygenase inhibitor, on exercise- and adenosine-induced bronchoconstriction in asthmatic subjects. Am J Respir Crit Care Med 1997; 155:875-880.
22. Heir T, Aanestad G, Carlsen KH, Larsen S. Respiratory tract infection and bronchial responsiveness in elite athletes and sedentary control subjects. Scand J Med Sci Sports 1995; 5:94-99.
23. Miller MR, Hankinson J, Brusasco V. Standardisation of spirometry. Eur Respir J 2005; 26:319-338.
24. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med. 2005; 352: 2163-2173.
25. Carlsen KH, Anderson SD, Bjermer L, Bonini S, Brusasco V, Canonica W, Cummiskey J, Delgado L, Del Giacco SR, Drobnic F, Haahtela T, Larsson K, Palange P, Popov T, van Cauwenberge P. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy 2008; 69:387-403. (Pubitemid 351341832)
26. Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol 2002; 109:615-620.
27. Pavord ID, Ward R, Woltmann G. Induced sputum eicosanoid concentration in asthma. Am J Respir Crit Care Med 1999; 160:1905-1909.
28. Samitas K, Chorianopoulos D, Vittorakis S, Zervas E, Economidou E, Papatheodorou G, Loukides S, GagaM. Exhaled cysteinyl-leukotrienes and 8-isoprostane in patients with asthma and their relation to clinical severity. Respir Med 2009; 103:750-756.
29. Wardlaw AJ, Hay H, Cromwell O, Collins JV, Kay AB. Leukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseases. J Allergy Clin Immunol 1989; 84:19-26.
30. Cabral AL, Conceição GM, Fonseca-Guedes CH, Martins MA. Exercise-induced bronchospasm in children: effects of asthma severity. Am J Respir Crit Care Med 1999; 159:1819-1823.
31. Csoma Z, Kharitonov SA, Balint B, Bush A, Wilson NM, Barnes PJ. Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med 2002; 166:1345-1349. (Pubitemid 35292700)
32. Pontier S, Heurtaux W, Riviere D, Escamilla R. Increased exhaled leukotrienes levels in adults with chronic cough. Eur Respir J 2003; 22(Suppl. 45):475s.
33. Zanconato S, Piovan V, Ghiro L, Corradi M, Alinovi R, Bodini A. Cysteinyl-leukotrienes as markers of airway inflammation in exhaled breath condensate of asthmatic children. Eur Respir J 2002; 20(Suppl. 38):412s.
34. Lex C, Zacharasiewicz A, Payne DN, Wilson NM, Nicholson AG, Kharitonov SA, Barnes PJ, Bush A. Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study. Respir Res 2006; 7:63.
35. Soyer OU, Dizdar EA, Keskin O, Lilly C, Kalayci O. Comparison of two methods for exhaled breath condensate collection. Allergy 2006; 61:1016-1018.
36. Tufvesson E, Bjermer L. Methodological improvements for measuring eicosanoids and cytokines in exhaled breath condensate. Respir Med 2006; 100:34-38.
37. Huszar E, Szabo Z, Jakab A, Barta I, Herjavecz I, Horvath I. Comparative measurement of thromboxane A2 metabolites in exhaled breath condensate by different immunoassays. Inflamm Res 2005; 54:350-355.
38. Debley JS, Ohanian AS, Spiekerman CF, Aitken ML, Hallstrand TS. Effects of bronchoconstriction, minute ventilation, and deep inspiration on the composition of exhaled breath condensate (EBC). Chest 2010 Apr 9. [Epub ahead of print]
39. Dupont LJ, Rochette F, Demedts MG, Verleden GM. Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-naive patients with asthma. Am J Respir Crit Care Med 1998; 157: 894-898.
40. Nishio K, Odajima H, Motomura C, Nakao F, Nishima S. Exhaled nitric oxide and exercise-induced bronchospasm assessed by FEV1, FEF25-75% in childhood asthma. J Asthma 2007; 44:475-478.
41. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 1998; 53: 91-95.
42. Anderson SD, Daviskas E. The mechanism of exercise-induced asthma is. J Allergy Clin Immunol 2000; 106:453-459.
43. Yoshikawa T, Shoji S, Fujii T, Kanazawa H, Kudoh S, Hirata K, Yoshikawa J. Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma. Eur Respir J 1998; 12:879-884.