Close relationship between strict blood glucose control, including suppression of blood glucose variability, and mortality reduction in acutely ill patients with glucose intolerance investigated by means of a bedside-type artificial pancreas

Journal of Artificial Organs

Volumn 13, Issue 3, 2010, Pages 151-160

  Hoshino, Masami ^a   Haraguchi, Yoshikura ^b   Mizushima, Iwanori ^c   Sakai, Motohiro ^d  

^a Shisei Hospital   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION DISASTER MEDICAL CENTER   (Japan)

^c Nippon Engineering College   (Japan)

^d TOKYO WOMEN S MEDICAL UNIVERSITY MEDICAL CENTER EAST   (Japan)

Author keywords

Artificial pancreas; Blood glucose control; Blood glucose variability; Critically ill patients; Outcome

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; ARTIFICIAL PANCREAS; BLOOD GLUCOSE MONITORING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROGNOSIS;

ADULT; AGED; BLOOD GLUCOSE; CRITICAL ILLNESS; FEMALE; GLUCOSE INTOLERANCE; HUMANS; HYPERGLYCEMIA; INSULIN; MALE; MIDDLE AGED; PANCREAS, ARTIFICIAL; TREATMENT OUTCOME;

EID: 78149416091     PISSN: 14347229     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10047-010-0509-9     Document Type: Article

References (53)

1. The Diabetic Control and Complications Trial Research Group 1993 The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus N Eng J Med 329 977 986 10.1056/NEJM199309303291401 (Pubitemid 23307905)
2. United kingdom Prospective Diabetes Study Group 1998 Intensive blood-glucose control with sulphonylurea or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS33) Lancet 352 837 853 10.1016/S0140-6736(98)07019-6 (Pubitemid 28416718)
3. K Malmberg 1997 Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus: DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group B M J 314 1512 1515 1:CAS:528:DyaK2sXjvF2jtLc%3D
4. AP Furnary KJ Zerr GL Grunkemeier A Starr 1999 Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures Ann Thorac Surg 67 352 362 1:STN:280:DyaK1M3htFGisg%3D%3D 10.1016/S0003-4975(99)00014-4 10197653 (Pubitemid 29176984)
5. G Van den Berghe P Wouters F Weekers C Werwaest F Bruyninckx M Schetz D Vlasselaers P Ferdinande P Lauwers R Buillon 2001 Intensive insulin therapy in the critically ill patients N Eng J Med 345 1359 1367 10.1056/NEJMoa011300
6. G Van den Berghe A Wilmer G Hermans W Meersseman PJ Wouters I Milants E Van Wijngaerden H Bobbaers R Buillon 2006 Intensive insulin therapy in the Medical ICU N Engl J Med 354 449 461 10.1056/NEJMoa052521 16452557 (Pubitemid 43200296)
7. SJ Finney C Zekveld A Elia TW Evans 2003 Glucose control and mortality in critically ill patients JAMA 290 2041 2047 1:CAS:528:DC%2BD3sXot1Kmu74%3D 10.1001/jama.290.15.2041 14559958 (Pubitemid 37430587)
8. JS Krinsley 2004 Effect of an intensive glucose management protocol on the mortality of critically ill adult patients Mayo Clin Proc 79 992 1000 10.4065/79.8.992 15301325
9. The International Surviving Sepsis Campaign Guidelines Committee 2008 Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 Crit Care Med 36 296 327 10.1097/01.CCM. 0000298158.12101.41
10. JH Taylor GJ Beilman 2005 Hyperglycemia in the intensive care unit: no longer just a marker of illness severity Surg Infect 6 233 245 10.1089/sur.2005.6.233 (Pubitemid 41388158)
11. TA Baird MW Parsons T Phanh KS Butcher PM Desmond BM Tress PG Colman BR Chambers SM Davis 2003 Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome Stroke 34 2208 2214 1:CAS:528:DC%2BD3sXmvVWhu7c%3D 10.1161/01.STR.0000085087.41330.FF 12893952 (Pubitemid 37099838)
12. M Vogelzang ICC van der Horst MWN Nijsten 2004 Hyperglycaemic index as a tool to assess glucose control: a retrospective study Crit Care 8 R122 R127 10.1186/cc2840 15153239
13. V Srinivasan PC Spinella HR Drott CL Roth MA Helfaer V Nadkarni 2004 Association of timing, duration and intensity of hyperglycemia with intensive care unit mortality in critically ill children Pediatr Crit Care Med 5 329 336 10.1097/01.PCC.0000128607.68261.7C 15215001
14. JS Krinsley RL Jones 2006 Cost analysis of intensive glycemic control in critically ill adult patients Chest 129 644 650 10.1378/chest.129.3.644 16537863
15. G Van den Berhge PJ Wouters K Kesteloot DE Hilleman 2006 Analysis of healthcare resource utilization with intensive Insulin therapy in critically ill patients Crit Care Med 34 612 616
16. IB Hirsch M Brownlee 2005 Should minimal blood glucose variability become the gold standard of glycemic control? J Diabetes Complicat 19 178 181 10.1016/j.jdiacomp.2004.10.001 15866065 (Pubitemid 40615551)
17. KA Wintergerst B Buckingham L Gandrud BJ Wong S Kache DM Wilson 2006 Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit Pediatrics 118 173 179 10.1542/peds.2005-1819 16818563 (Pubitemid 46071160)
18. M Egi R Bellomo E Stachowski CJ French G Hart 2006 Variability of blood glucose concentration and short-term mortality in critically ill patients Anesthesiology 105 244 252 1:CAS:528:DC%2BD28Xntl2mt7k%3D 10.1097/00000542- 200608000-00006 16871057 (Pubitemid 44148168)
19. D Vlasselaers I Milants L Desmet PJ Wouters I Vanhorebeek I Van den Heuvel D Mesotten MP Casaer G Meyfroidt C Ingels J Muller S Van Cromphaut G Van den Berghe 2009 Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomized controlled study Lancet 373 547 556 1:CAS:528:DC%2BD1MXhvFGltLs%3D 10.1016/S0140-6736(09)60044-1 19176240
20. FM Brunkhorst C Engel F Bloos AM Hellmann M Ragaller N Weiler O Moerer M Gruendling M Oppert S Grond D Olthoff U Jaschinski S John R Rossaint T Welte M Schaefer P Kern E Kuhnt M Kiehntopf C Hartog C Natanson M Loeffler K Reinhart 2008 for the German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis N Engl J Med 358 125 139 1:CAS:528:DC%2BD1cXltFWltQ%3D%3D 10.1056/NEJMoa070716 18184958
21. NICE-SUGAR Study Investigators S Finster DR Chittock SY Su D Blair D Foster V Dhingra R Bellomo D Cook P Dodek WR Henderson PC Hebert S Heritier DK Heyland C McArthur E McDonald I Mitchell JA Myburgh R Norton J Potter BG Robinson JJ Ronco 2009 Intensive versus conventional glucose control in critically ill patients N Eng J Med 360 1283 1297 10.1056/NEJMoa0810625
22. S Laver S Preston D Turner C Mckinstry A Padkin 2004 Implementing intensive insulin therapy: development and audit of the bath insulin protocol Anaesth Intensive Care 32 311 316 1:STN:280:DC%2BD2czmtFKgsQ%3D%3D 15264724
23. S Kanji A Singh M Tierney H Meggison L McIntyre PC Hebert 2004 Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adults Intensive Care Med 30 804 810 10.1007/s00134-004-2252-2 15127193 (Pubitemid 38639470)
24. G Van den Berhge A Wilmer I Milants PJ Wouters B Bouckaert F Bruyninckx R Bouillon M Schetz 2006 Intensive insulin therapy in mixed medical/surgical intensive care units. Benefit versus harm Diabetes 55 3151 3159 10.2337/db06-0855 (Pubitemid 44923655)
25. NR Orford 2006 Intensive insulin therapy in septic shock Crit Care Resusc 8 230 234 16930111
26. EC McNay A Williamson RJ McCrimmon RS Sherwin 2006 Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia Diabetes 55 1088 1095 1:CAS:528:DC%2BD28XjsVGmtbo%3D 10.2337/diabetes.55.04.06.db05-1314 16567533 (Pubitemid 44100186)
27. I Mackenzie S Ingle S Zaidi S Buczaski 2005 Tight glycemic control: a survey of intensive care practice in large English hospitals Intensive Care Med 31 1136 10.1007/s00134-005-2677-2 16052274 (Pubitemid 41125348)
28. J Plank J Blaha J Cordingley ME Wilinska LJ Chassin C Morgan S Squire M Haluzik J Kremen S Svacina W Toller A Plasnik M Ellmerer R Hovorka TR Pieber 2006 Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients Diabetes Care 29 271 276 10.2337/diacare.29.02.06.dc05-1689 16443872 (Pubitemid 44106503)
29. C De Block BMY Keenoy L Van Gaal P Rogiers 2006 Intensive insulin therapy in the intensive care unit Diabetes Care 29 1750 1756 10.2337/dc05-2353 16873775 (Pubitemid 44156625)
30. TM Scalea BV Bochicchio KM Bochicchio SB Johnson M Joshi A Pyle 2007 Tight glycemic control in critically injured trauma patients Ann Surg 246 605 612 10.1097/SLA.0b013e318155a789 17893497
31. B Collier LA Dossett AK May JJ Diaz 2008 Glucose control and the inflammatory response Nutr Clin Pract 23 3 15 10.1177/011542650802300103 18203960 (Pubitemid 351438964)
32. TM Vriesendorp S van Santen H DeVries E De Jonge FR Rosendaal MJ Schultz JBL Hoekstra 2006 Predisposing factors for hypoglycemia in the intensive care unit Crit Care Med 34 96 101 10.1097/01.CCM.0000194536.89694.06 16374162 (Pubitemid 43032385)
33. th World Congress of the International Society for Artificial Organs [Abstract]. No. G-02-36989 1989; p 308.
34. Haraguchi Y, Hoshino M, Kirita M. Intravenous hyperalimentation and artificial endocrine pancreas for patients with impaired glucose tolerance. In 25th Congress of European Society for Surgical Research [Abstract]. No. 178 1990; p 84.
35. M Hoshino Y Haraguchi H Hirasawa M Sakai H Saegusa K Hayashi N Horita H Ohsawa 2001 Close relationship of tissue plasminogen activator-plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas Crit Care 5 88 89 1:STN:280:DC%2BD3M3htVygtQ%3D%3D 10.1186/cc1194 11299067
36. M Hoshino Y Haraguchi H Hirasawa I Mizushima C Tanaka Y Morita T Yokoi M Sakai 2006 Measurement of insulin clearance and factors affecting insulin clearance in septic patients with glucose intolerance-analysis under strict blood glucose control by means of bedside-type artificial pancreas Chiba Med J 82 149 161 1:CAS:528:DC%2BD28Xns1Wltbk%3D
37. Hoshino M, Haraguchi Y, Mizushima I, Kajiwara S, Takagi M. Significance of the suppression of blood glucose variability in acutely ill severe patients with glucose intolerance evaluated by means of bedside-type artificial pancreas [Abstract] Crit Care. 2008;12 Suppl 2:S60.
38. Hoshino M, Haraguchi Y, Mizushima I, Sakai M, Kajiwara S, Takagi M. High blood glucose variability in acute phase is one of the most important risk factors relating to the outcome in acutely ill severe patients with glucose intolerance. [Abstract] Crit Care. 2009;13 Suppl 1:S49-50.
39. M Hoshino Y Haraguchi I Muzushima M Sakai 2009 Recent progress in mechanical artificial pancreas J Artif Organs 12 141 149 1:CAS:528: DC%2BD1MXht12gsrbL 10.1007/s10047-009-0463-6 19894087
40. RC Bone RA Balk FB Cerra AM Fein WA Knaus RM Schein WJ Sibbald 1992 Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Chest 101 1644 1655 1:STN:280:DyaK383ovFeiuw%3D%3D 10.1378/chest.101.6.1644 1303622
41. JL Vincent A de Mendonca F Cantraine R Moreno J Takala PM Suter CL Sprung F Colardyn S Blecher 1998 Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units Crit Care Med 26 1793 1800 1:STN:280:DyaK1M%2FjvFKktw%3D%3D 9824069
42. RP Dellinger JM Carlet H Masur H Gerlach T Calandra J Cohen J Gea-Banacloche D Keh JC Marshall MM Parker G Ramsay JL Zimmerman JL Vincent MM Levy 2004 Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock Crit Care Med 32 858 873 10.1097/01.CCM.0000117317.18092.E4 15090974 (Pubitemid 38344143)
43. AM Laird PR Miller PD Kilgo JW Meredith MC Chang 2004 Relationship of early hyperglycemia to mortality in trauma patients J Trauma 56 1058 1062 10.1097/01.TA.0000123267.39011.9F 15179246
44. Bochicchio GV, Sung Jin, Joshi M, Bochicchio K, Johnson SB, Meyer W, Scalea TM. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma. 2005;58:921-4. (Pubitemid 40776893)
45. LA Dossett H Cao NT Mowery MJ Dortch JM Morris Jr AK May 2008 Blood glucose variability is associated with mortality in the surgical intensive care unit Am Surg 74 679 685 18705566
46. NA Ali JM O'Brien Jr K Dungan G Phillips CB Marsh S Lemeshow AF Connors Jr JC Preiser 2008 Glucose variability and mortality in patients with sepsis Crit Care Med 36 2316 2321 10.1097/CCM.0b013e3181810378 18596625
47. JS Krinsley 2008 Glycemic variability: a strong independent predictor of mortality in critically ill patients Crit Care Med 36 3008 3013 1:CAS:528:DC%2BD1cXht1KmtbnF 10.1097/CCM.0b013e31818b38d2 18824908
48. A Risso F Mercuri L Quagliaro G Damante A Ceriello 2001 Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture Am J Physiol Endocrinol Metab 281 E924 E930 1:CAS:528:DC%2BD3MXos1aht78%3D 11595647
49. L Quagliaro L Piconi R Assaloni L Martinelli E Motz A Ceriello 2003 Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells Diabetes 52 2795 2804 1:CAS:528:DC%2BD3sXovVagtL0%3D 10.2337/diabetes.52.11.2795 14578299 (Pubitemid 37339710)
50. L Monnier E Mas C Ginet F Michel L Villon JP Cristol C Colette 2006 Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes JAMA 295 1681 1687 1:CAS:528:DC%2BD28XjsVequ7k%3D 10.1001/jama.295.14.1681 16609090
51. K Esposito F Nappo R Marfella G Giugliano F Giugliano M Ciotola L Quagliaro A Ceriello D Guigliano 2002 Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress Circulation 106 2067 2072 1:CAS:528:DC%2BD38Xns1SnsL4%3D 10.1161/01.CIR. 0000034509.14906.AE 12379575 (Pubitemid 35192812)
52. B Holtfreter C Bandt SO Kuhn U Grunwald C Lehmann C Schutt M Grundling 2006 Serum osmolality and outcome in intensive care unit patients Acuta Anaesthesiol Scand 50 970 977 1:STN:280:DC%2BD28vpvVWhtQ%3D%3D 10.1111/j.1399-6576.2006.01096.x (Pubitemid 44272720)
53. N Otto R Schindler A Lun O Boenisch U Frei M Oppert 2008 Hyperosmotic stress enhances cytokine production and decreases phagocytosis in vitro Crit Care 12 R107 10.1186/cc6989 18710523