Genetic bottlenecks and the hazardous game of population reduction in cell line based research

Experimental Cell Research

Volumn 316, Issue 20, 2010, Pages 3379-3386

  Gisselsson, David ^a   Lindgren, David ^a   Mengelbier, Linda Holmquist ^a   Øra, Ingrid ^b   Yeger, Herman ^c  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cancer; Cell line; Chromosomal instability; Genetic bottle neck; Population bottle neck; SNP array

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER RESEARCH; CELL CLONE; CELL COUNT; CELL CULTURE; CELL DIVISION; CELL EXPANSION; CELL POPULATION; CHROMOSOME SEGREGATION; CLONAL VARIATION; CONTROLLED STUDY; CYTOGENETICS; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOMIC INSTABILITY; GENOTYPE; MEDICAL RESEARCH; MOUSE; NONHUMAN; POPULATION REGULATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE;

EID: 78149406442     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.07.010     Document Type: Article

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