Pharmacokinetics of a novel nifedipine and pH-sensitive N-succinyl chitosanalginate hydrogel bead in rabbits

Drug Development and Industrial Pharmacy

Volumn 36, Issue 12, 2010, Pages 1463-1468

  Zhu, Xu Jiang ^a,b,c   Yuan, Wei ^b   Li, Ping ^d   Liu, Xia ^a   He, Jun Quan ^b  

^a LANZHOU INSTITUTE OF CHEMICAL PHYSICS   (China)

^b Gansu Institute of Drug Control   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d LANZHOU UNIVERSITY   (China)

Author keywords

HPLCUV; Hydrogel; N succinyl chitosan; Nifedipine; PH sensitivity; Pharmacokinetics; Rabbit serum

Indexed keywords

ALGINIC ACID; CHITOSAN; N SUCCINYLCHITOSAN; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; DRUG BLOOD LEVEL; EXPERIMENTAL RABBIT; HYDROGEL; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PH; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ALGINATES; ANIMALS; AREA UNDER CURVE; CALCIUM CHANNEL BLOCKERS; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MICROSPHERES; NIFEDIPINE; RABBITS;

EID: 78149374547     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.488644     Document Type: Article

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