Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: Insights from PyMT transgenic mouse model

Oncology Reports

Volumn 24, Issue 5, 2010, Pages 1233-1239

  McCune, Kasi ^a   Mehta, Rutika ^a   Thorat, Mangesh A ^a   Badve, Sunil ^a   Nakshatri, Harikrishna ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Breast cancer; Estrogen receptor; FOXA1; GATA 3

Indexed keywords

BIOLOGICAL MARKER; CORN OIL; ESTROGEN RECEPTOR ALPHA; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; PHENETHYL ISOTHIOCYANATE; TRANSCRIPTION FACTOR GATA 3; VIRUS T ANTIGEN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; GROWTH INHIBITION; HISTOPATHOLOGY; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MALE; MAMMARY GLAND; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; STEM CELL; TRANSGENIC ANIMAL; TUMOR GROWTH;

ANIMALS; ANTICARCINOGENIC AGENTS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ESTROGEN RECEPTOR ALPHA; FEMALE; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; ISOTHIOCYANATES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; NEOPLASTIC STEM CELLS; PROGNOSIS;

EID: 78149343486     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000977     Document Type: Article

References (27)

1. Sorlie T, Perou CM, Tibshirani R, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98: 10869-10874, 2001. (Pubitemid 32878711)
2. Badve S, Turbin D, Thorat MA, et al: FOXA1 expression in breast cancer correlation with luminal subtype A and survival. Clin Cancer Res 13: 4415-4421, 2007. (Pubitemid 47219708)
3. Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS and Brown M: Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer. Cancer Res 67: 6477-6483, 2007. (Pubitemid 47037533)
4. Cheang MC, Chia SK, Voduc D, et al: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101: 736-750, 2009.
5. McCune K, Bhat-Nakshatri P, Thorat MA, Nephew KP, Badve S and Nakshatri H: Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet. Cancer Res 70: 685-696, 2010.
6. Lin EY, Jones JG, Li P, et al: Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 163: 2113-2126, 2003. (Pubitemid 37310040)
7. Wu XJ and Hua X: Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound. Cancer Biol Ther 6: 646-647, 2007.
8. Reen RK, Dombkowski AA, Kresty LA, et al: Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. Cancer Res 67: 6484-6492, 2007.
9. Trachootham D, Zhou Y, Zhang H, et al: Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10: 241-252, 2006. (Pubitemid 44311067)
10. Thorat MA, Marchio C, Morimiya A, et al: FOXA1 expression in breast cancer is associated with Luminal subtype and good prognosis. J Clin Pathol 2007.
11. Jacquemier J, Charafe-Jauffret E, Monville F, et al: Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer. Breast Cancer Res 11: R23, 2009.
12. Kouros-Mehr H, Bechis SK, Slorach EM, et al: GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell 13: 141-152, 2008. (Pubitemid 351163164)
13. Mehra R, Varambally S, Ding L, et al: Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis. Cancer Res 65: 11259-11264, 2005.
14. Dydensborg AB, Rose AA, Wilson BJ, et al: GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene 28: 2634-2642, 2009.
15. Conaway CC, Wang CX, Pittman B, et al: Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res 65: 8548-8557, 2005.
16. Asselin-Labat ML, Sutherland KD, Barker H, et al: Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol 9: 201-209, 2007.
17. Kouros-Mehr H, Slorach EM, Sternlicht MD and Werb Z: GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127: 1041-1055, 2006.
18. Diehn M, Cho RW, Lobo NA, et al: Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458: 780-783, 2009.
19. Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R and Hannon GJ: A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev 21: 3238-3243, 2007.
20. Ginestier C, Hur MH, Charafe-Jauffret E, et al: ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1: 555-567, 2007.
21. Herschkowitz JI, Simin K, Weigman VJ, et al: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8: R76, 2007.
22. Natrajan R, Lambros MB, Geyer FC, et al: Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype? Genes Chromosomes Cancer 48: 351-365, 2009.
23. Nakshatri H and Badve S: FOXA1 in breast cancer. Expert Rev Mol Med 11: E8, 2009.
24. Hu J, Straub J, Xiao D, et al: Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. Cancer Res 67: 3569-3573, 2007.
25. Xiao D, Johnson CS, Trump DL and Singh SV: Proteasome-mediated degradation of cell division cycle 25C and cyclindependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells. Mol Cancer Ther 3: 567-575, 2004.
26. Mi L, Xiao Z, Hood BL, et al: Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem 283: 22136-22146, 2008.
27. Phillips TM, McBride WH and Pajonk F: The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 98: 1777-1785, 2006.