Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects

Journal of Lipid Research

Volumn 51, Issue 11, 2010, Pages 3174-3184

  Kriska, Tamas ^a   Pilat, Anna ^a   Schmitt, Jared C ^a   Girotti, Albert W ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Lipid peroxidation; Lipid peroxide translocation; Oxidative stress

Indexed keywords

7 ALPHA HYDROPEROXYCHOLESTEROL; CHOLESTEROL HYDROPEROXIDE; LIPID HYDROPEROXIDE; REACTIVE OXYGEN METABOLITE; STEROL CARRIER PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL KILLING; CELLULAR DISTRIBUTION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; FLUORESCENCE ANALYSIS; GENE FUNCTION; GENE OVEREXPRESSION; MAMMAL CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR CLONING; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WILD TYPE;

ACETANILIDES; ANIMALS; APOPTOSIS; BENZOXAZINES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE; CHOLESTEROL; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; RATS; REACTIVE OXYGEN SPECIES; THIAZOLES;

EID: 78149304368     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M008342     Document Type: Article

References (40)

1. Phillips, M. C., W. J. Johnson, and G. H. Rothblat. 1987. Mechanisms and consequences of cellular cholesterol exchange and transfer. Biochim. Biophys. Acta. 906: 223-276.
2. Dawidowicz, E. A. 1987. Lipid exchange: transmembrane movement, spontaneous movement, and protein-mediated transfer of lipids and cholesterol. In Current Topics in Membranes and Transport. Vol. 29. R.D. Klausner, C. Kempf, and J. van Renswoude, editors. Academic Press, New York. 175-202.
3. Brown, R. E. 1992. Spontaneous lipid transfer between organized lipid assemblies. Biochim. Biophys. Acta. 1113: 375-389.
4. Soccio, R. E., and J. L. Breslow. 2003. StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism. J. Biol. Chem. 278: 22183-22186.
5. Miller, W. L. 2007. Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim. Biophys. Acta. 1771: 663-676.
6. Scallen, T. J., A. Pastuszyn, B. J. Noland, R. Chanderbhan, A. Kharroubi, and G. V. Vanhouny. 1985. Sterol carrier and lipid transfer proteins. Chem. Phys. Lipids. 38: 239-261.
7. Gallegos, A. M., B. P. Atshaves, S. M. Storey, O. Starodub, A. D. Petrescu, H. Huang, A. L. McIntosh, G. G. Martin, H. Chao, A. B. Kier, et al. 2001. Gene structure, intracellular localization, and functional roles of sterol carrier protein-2. Prog. Lipid Res. 40: 498-563.
8. Stolowich, N. J., A. D. Petrescu, H. Huang, G. G. Martin, A. I. Scott, and F. Schroeder. 2002. Sterol carrier protein-2: structure reveals function. Cell. Mol. Life Sci. 59: 193-212.
9. Wirtz, K. W. A. 2006. Phospholipid transfer proteins in perspective. FEBS Lett. 580: 5436-5441.
10. Starodub, O., C. A. Jolly, B. P. Atshaves, J. B. Roths, E. J. Murphy, A. B. Kier, and F. Schroeder. 2000. Sterol carrier protein-2 immunolocalization in endoplasmic reticulum and stimulation of phospholipid formation. Am. J. Physiol. Cell Physiol. 279: C1259-C1269.
11. Woodford, J. K., S. M. Colles, S. C. Myers-Payne, J. T. Billheimer, and F. Schroeder. 1995. Sterol carrier protein-2 stimulates intermembrane sterol transfer by direct membrane interaction. Chem. Phys. Lipids. 76: 73-84.
12. Colles, S. M., J. K. Woodford, D. Moncecchi, S. C. Myers-Payne, L. R. McLean, J. T. Billheimer, and F. Schroeder. 1995. Cholesterol interaction with recombinant human sterol carrier protein-2. Lipids. 30: 795-803.
13. Porter, N. A., S. E. Caldwell, and K. A. Mills. 1995. Mechanisms of free radical oxidation of unsaturated lipids. Lipids. 30: 277-290.
14. Girotti, A. W. 1998. Lipid hydroperoxide generation, turnover, and effector action in biological systems. J. Lipid Res. 39: 1529-1542.
15. Vila, A., W. Korytowski, and A. W. Girotti. 2000. Dissemination of peroxidative stress via intermembrane transfer of lipid hydroperoxides: model studies with cholesterol hydroperoxides. Arch. Biochem. Biophys. 380: 208-218.
16. Girotti, A. W. 2008. Translocation as a means of disseminating lipid hydroperoxide-induced oxidative damage and effector action. Free Radic. Biol. Med. 44: 956-968.
17. Vila, A., W. Korytowski, and A. W. Girotti. 2001. Spontaneous intermembrane transfer of various cholesterol-derived hydroperoxide species: kinetic studies with model membranes and cells. Biochemistry. 40: 14715-14726.
18. Vila, A., V. V. Levchenko, W. Korytowski, and A. W. Girotti. 2004. Sterol carrier protein-2-facilitated intermembrane transfer of cholesterol- and phospholipid-derived hydroperoxides. Biochemistry. 43: 12592-12605.
19. Kriska, T., V. V. Levchenko, W. Korytowski, B. P. Atshaves, F. Schroeder, and A. W. Girotti. 2006. Intracellular dissemination of peroxidative stress: internalization, transport, and lethal targeting of a cholesterol hydroperoxide species by sterol carrier protein-2-overexpressing hepatoma cells. J. Biol. Chem. 281: 23643-23651.
20. Kim, M. S., V. Wessely, and Q. Lan. 2005. Identification of mosquito sterol carrier protein-2 inhibitors. J. Lipid Res. 46: 650-657. (Pubitemid 43073274)
21. Larson, R. T., V. Wessely, Z. Jiang, and Q. Lan. 2008. Larvicidal activity of a sterol carrier protein-2 inhibitor in four species of mosquitoes. J. Med. Entomol. 45: 439-444.
22. Korytowski, W., P. G. Geiger, and A. W. Girotti. 1999. Lipid hydroperoxide analysis by high-performance liquid chromatography with mercury cathode electrochemical detection. Methods Enzymol. 300: 23-33.
23. Girotti, A. W., and W. Korytowski. 2000. Cholesterol as a singlet oxygen detector in biological systems. Methods Enzymol. 319: 85-100. (Pubitemid 30448033)
24. Esworthy, R. S., M. A. Baker, and F-F. Chu. 1995. Expression of selenium-dependent glutathione peroxidase in human breast tumor lines. Cancer Res. 55: 957-962.
25. Atshaves, B. P., A. D. Petrescu, O. Starodub, J. B. Roths, A. B. Kier, and F. Schroeder. 1999. Expression and intracellular processing of the 58 kDa sterol carier protein-2/3-oxoacyl-CoA thiolase in transfected mouse L-cell fibroblasts. J. Lipid Res. 40: 610-622.
26. Mossman, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65: 55-63.
27. Spector, D. L., R. D. Goldman, and L. A. Leinwald, editors. 1997. Cells: a Laboratory Manual. Vol. 1. Cold Spring Harbor Laboratory Press, New York.
28. Korytowski, W., M. Wrona, and A. W. Girotti. 1999. Radiolabeled cholesterol as a reporter for assessing one-electron turnover of lipid hydroperoxides. Anal. Biochem. 270: 123-132.
29. Reers, M., S. T. Smiley, C. Mottola-Hartshorn, A. Chen, M. Lin, and L. B. Chen. 1995. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol. 260: 406-417.
30. LeBel, C. P., H. Ischiropoulos, and S. C. Bondy. 1992. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5: 227-231.
31. Avdulov, N. A., S. V. Chochina, U. Igbavboa, C. S. Warden, F. Schroeder, and W. G. Wood. 1999. Lipid binding to sterol carrier protein-2 is inhibited by ethanol. Biochim. Biophys. Acta. 1437: 37-45.
32. Veal, E. A., A. M. Day, and B. A. Morgan. 2007. Hydrogen peroxide sensing and signaling. Mol. Cell. 26: 1-14.
33. D'Autreaux, B., and M. B. Toledano. 2007. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Mol. Cell. Biol. 8: 813-824.
34. Forman, H. J., M. Maiorino, and F. Ursini. 2010. Signaling functions of reactive oxygen species. Biochemistry. 49: 835-842.
35. Korytowski, W., D. Rodriguez-Agudo, A. Pilat, and A. W. Girotti. 2010. StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions. Biochem. Biophys. Res. Commun. 392: 58-62.
36. Murphy, E. J., T. Stiles, and F. Schroeder. 2000. Sterol carrier protein-2 expression alters phospholipid content and fatty acyl composition in L-cell fibroblasts. J. Lipid Res. 41: 788-796.
37. Choinowski, T., H. Hauser, and K. Piontek. 2000. Structure of sterol carrier protein-2 at 1.8 A resolution reveals a hydrophobic tunnel suitable for lipid binding. Biochemistry. 39: 1897-1902. (Pubitemid 30123996)
38. Dyer, D. H., S. Lovell, J. B. Thoden, H. M. Holden, I. Rayment, and Q. Lan. 2003. The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35 A resolution. J. Biol. Chem. 278: 39085-39091.
39. Vila, A., W. Korytowski, and A. W. Girotti. 2002. Spontaneous transfer of phospholipid and cholesterol hydroperoxides between cell membranes and low density lipoprotein: assessment of reaction kinetics and prooxidant effects. Biochemistry. 41: 13705-13716.
40. Bloch, K. E. 1983. Sterol structure and membrane function. Crit. Rev. Biochem. 14: 47-92.