Association of cumulative lead exposure with Parkinson's disease

Environmental Health Perspectives

Volumn 118, Issue 11, 2010, Pages 1609-1613

  Weisskopf, Marc G ^a,b   Weuve, Jennifer ^a,c   Nie, Huiling ^d   Saint Hilaire, Marie Helene ^e   Sudarsky, Lewis ^f   Simon, David K ^g   Hersh, Bonnie ^h   Schwartz, Joel ^a   Wright, Robert O ^a,b,i   Hu, Howard ^j  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d PURDUE UNIVERSITY   (United States)

^e BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h HARVARD VANGUARD MEDICAL ASSOCIATES   (United States)

ⁱ BOSTON CHILDREN S HOSPITAL   (United States)

^j UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

Biomarker; Bone lead; Case control study; Epidemiology; Humans; Metals; Risk factor. environ health perspect 118:1609 1613 (2010)

Indexed keywords

LEAD;

AGED; ARTICLE; BONE LEVEL; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; PARKINSON DISEASE; PATELLA; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TIBIA;

AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; LEAD; LOGISTIC MODELS; MALE; MASSACHUSETTS; MIDDLE AGED; ODDS RATIO; PARKINSON DISEASE; PATELLA; SPECTROMETRY, X-RAY EMISSION; TIBIA;

EID: 78149286513     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002339     Document Type: Article

References (34)

1. Aro A, Amarasiriwardena C, Lee ML, Kim R, Hu H. 2000. Validation of K x-ray fluorescence bone lead measurements by inductively coupled plasma mass spectrometry in cadaver legs. Med Phys 27(1):119-123.
2. Aro AC, Todd AC, Amarasiriwardena C, Hu H. 1994. Improvements in the calibration of 109Cd K x-ray fluorescence systems for measuring bone lead in vivo. Phys Med Biol 39(12):2263-2271.
3. Bell B, Rose CL, Damon A. 1966. The Veterans Administration longitudinal study of healthy aging. Gerontologist 6(4):179-184.
4. Burger DE, Milder FL, Morsillo PR, Adams BB, Hu H. 1990. Automated bone lead analysis by K-x-ray fluorescence for the clinical environment. Basic Life Sci 55:287-292.
5. Coon S, Stark A, Peterson E, Gloi A, Kortsha G, Pounds J, et al. 2006. Whole-body lifetime occupational lead exposure and risk of Parkinson's disease. Environ Health Perspect 114:1872-1876.
6. Cory-Slechta DA. 1997. Relationships between Pb-induced changes in neurotransmitter system function and behavioral toxicity. Neurotoxicology 18(3):673-688.
7. Di Castelnuovo A, Quacquaruccio G, Donati MB, de Gaetano G, Iacoviello L. 2009. Spousal concordance for major coronary risk factors: a systematic review and meta-analysis. Am J Epidemiol 169(1):1-8.
8. Elbaz A, Moisan F. 2008. Update in the epidemiology of Parkinson's disease. Curr Opin Neurol 21(4):454-460.
9. Ercal N, Gurer-Orhan H, Aykin-Burns N. 2001. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1(6):529-539.
10. Gedeon Y, Ramesh GT, Wellman PJ, Jadhav AL. 2001. Changes in mesocorticolimbic dopamine and D1/D2 receptor levels after low level lead exposure: a time course study. Toxicol Lett 123(2-3):217-226.
11. Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Kortsha GX, Brown GG, et al. 1997. Occupational exposures to metals as risk factors for Parkinson's disease. Neurology 48(3):650-658.
12. Govoni S, Memo M, Spano PF, Trabucchi M. 1979. Chronic lead treatment differentially affects dopamine synthesis in various rat brain areas. Toxicology 12(3):343-349.
13. Graham JW. 2009. Missing data analysis: making it work in the real world. Annu Rev Psychol 60:549-576.
14. Hernan MA, Takkouche B, Caamano-Isorna F, Gestal-Otero JJ. 2002. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann Neurol 52(3):276-284.
15. Hu H, Milder FL, Burger DE. 1990. X-ray fluorescence measurements of lead burden in subjects with low-level community lead exposure. Arch Environ Health 45(6):335-341.
16. Hu H, Rabinowitz M, Smith D. 1998. Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect 106:1-8.
17. Hughes AJ, Daniel SE, Kilford L, Lees AJ. 1992. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181-184.
18. Invernizzi M, Carda S, Viscontini GS, Cisari C. 2009. Osteoporosis in Parkinson's disease. Parkinsonism Relat Disord 15(5):339-346.
19. Jadhav AL, Ramesh GT. 1997. Pb-induced alterations in tyrosine hydroxylase activity in rat brain. Mol Cell Biochem 175(1-2):137-141.
20. Jenner P. 2003. Oxidative stress in Parkinson's disease. Ann Neurol 53(suppl 3):S26-S38.
21. Kim R, Landrigan C, Mossmann P, Sparrow D, Hu H. 1997. Age and secular trends in bone lead levels in middle-aged and elderly men: three-year longitudinal follow-up in the Normative Aging Study. Am J Epidemiol 146(7):586-591.
22. Kuhn W, Winkel R, Woitalla D, Meves S, Przuntek H, Muller T. 1998. High prevalence of parkinsonism after occupational exposure to lead-sulfate batteries. Neurology 50(6):1885-1886.
23. Lai BC, Marion SA, Teschke K, Tsui JK. 2002. Occupational and environmental risk factors for Parkinson's disease. Parkinsonism Relat Disord 8(5):297-309.
24. Lasley SM. 1992. Regulation of dopaminergic activity, but not tyrosine hydroxylase, is diminished after chronic inorganic lead exposure. Neurotoxicology 13(3):625-635.
25. Lucchi L, Memo M, Airaghi ML, Spano PF, Trabucchi M. 1981. Chronic lead treatment induces in rat a specific and differential effect on dopamine receptors in different brain areas. Brain Res 213(2):397-404.
26. Minnema DJ, Greenland RD, Michaelson IA. 1986. Effect of in vitro inorganic lead on dopamine release from superfused rat striatal synaptosomes. Toxicol Appl Pharmacol 84(2):400-411.
27. Missale C, Battaini F, Govoni S, Castelletti L, Spano PF, Trabucchi M. 1984. Chronic lead exposure differentially affects dopamine transport in rat striatum and nucleus accumbens. Toxicology 33(1):81-90.
28. Pals P, Van Everbroeck B, Grubben B, Viaene MK, Dom R, van der Linden C, et al. 2003. Case-control study of environmental risk factors for Parkinson's disease in Belgium. Eur J Epidemiol 18(12):1133-1142.
29. Rybicki BA, Johnson CC, Gorell JM. 1995. Demographic differences in referral rates to neurologists of patients with suspected Parkinson's disease: implications for case-control study design. Neuroepidemiology 14(2):72-81.
30. Sanz P, Nogue S, Vilchez D, Vilchez J, Casal A, Logroscino G. 2007. Progressive supranuclear palsy-like parkinsonism resulting from occupational exposure to lead sulphate batteries. J Int Med Res 35(1):159-163.
31. Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, Mayeux R, et al. 1999. Parkinson disease in twins: an etiologic study. JAMA 281(4):341-346.
32. Tavakoli-Nezhad M, Barron AJ, Pitts DK. 2001. Postnatal inorganic lead exposure decreases the number of spontaneously active midbrain dopamine neurons in the rat. Neurotoxicology 22(2):259-269.
33. Weisskopf MG, Proctor SP, Wright RO, Schwartz J, Spiro A 3rd, Sparrow D, et al. 2007. Cumulative lead exposure and cognitive performance among elderly men. Epidemiology 18(1):59-66.
34. Winkel R, Kuhn W, Przuntek H. 1995. Chronic intoxication with lead and sulfur compounds may produce Parkinson's disease. J Neural Transm Suppl 46:183-187.