Lyngbyacyclamides A and B, novel cytotoxic peptides from marine cyanobacteria Lyngbya sp.

Tetrahedron Letters

Volumn 51, Issue 49, 2010, Pages 6384-6387

  Maru, Norihito ^a   Ohno, Osamu ^a   Uemura, Daisuke ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Cyclic peptide; Cytotoxicity; Lyngbya sp.; Lyngbyacyclamide A

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; LYNGBYACYCLAMIDE A; LYNGBYACYCLAMIDE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYANOBACTERIUM; CYTOTOXICITY; DEGRADATION KINETICS; HYDROLYSIS; JAPAN; LYNGBYA; MARINE BACTERIUM; MELANOMA B16; MOUSE; NONHUMAN; SPECTROSCOPY; STEREOCHEMISTRY;

CYANOBACTERIA; LYNGBYA;

EID: 78149285175     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.06.105     Document Type: Article

References (12)

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9. The retention times for the Marfey's derivatives of standards were: l-hyPro, 10.6 min; d-hyPro, 11.2 min; l-Glu, 35.8 min; l-Pro, 37.2 min; d-Pro, 41.5 min; d-Glu, 42.3 min; l-Val, 43.2 min; l-Phe, 44.1 min; d-Val, 48.4 min; l-Leu, 48.9 min; l-NMeIle, 49.3 min; d-Phe, 50.8 min; d-Leu, 52.5 min, and d-NMeIle, 56.6 min [Develosil ODS-MG-5, 4.6 × 250 mm, 1.0 mL/min, 340 nm, gradient of 20% MeOH/20 mM acetate buffer (pH 4.0) to MeOH over 60 min], and l-Hse, 33.8 min; l-Thr, 34.0 min; d-Hse, 35.1 min, and d-Thr, 37.9 min [Develosil ODS-MG-5, 4.6 × 250 mm, 0.8 mL/min, 340 nm, 30% MeOH/0.1% aqueous TFA].
10. The retention times for the Marfey's derivatives of 1 were: l-Glu, 36.0 min; l-Pro, 37.3 min; l-Val, 43.4 min; l-NMeIle, 49.5 min; d-Phe, 51.0 min, and d-Leu, 52.7 min [Develosil ODS-MG-5, 4.6 × 250 mm, 1.0 mL/min, 340 nm, gradient of 20% MeOH/20 mM acetate buffer (pH 4.0) to MeOH over 60 min], and l-Hse, 33.7 min and l-Thr, 34.0 min [Develosil ODS-MG-5, 4.6 × 250 mm, 0.8 mL/min, 340 nm, 30% MeOH/0.1% aqueous TFA].
11. The retention times for the Marfey's derivatives of 2 were: l-hyPro, 10.6 min; l-Glu, 35.9 min; l-Val, 43.3 min; l-NMeIle, 49.4 min; d-Phe, 50.9 min, and d-Leu, 52.6 min [Develosil ODS-MG-5, 4.6 × 250 mm, 1.0 mL/min, 340 nm, gradient of 20% MeOH/20 mM acetate buffer (pH 4.0) to MeOH over 60 min], and l-Hse, 33.7 min and l-Thr, 34.0 min [Develosil ODS-MG-5, 4.6 × 250 mm, 0.8 mL/min, 340 nm, 30% MeOH/0.1% aqueous TFA].
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