Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. in vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 6969-6974

  Woltering, Thomas J ^a   Wichmann, Jürgen ^a   Goetschi, Erwin ^a   Knoflach, Frédéric ^a   Ballard, Theresa M ^a   Huwyler, Jörg ^a,b   Gatti, Silvia ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

Author keywords

1,3 Dihydro benzo b 1,4 diazepin 2 one; Cognition models; In vivo activity; LY354740; Metabotropic glutamate receptors; MGluR2 antagonist; MGluR3 antagonist; Rats

Indexed keywords

1,3 DIHYDRO BENZO[B][1,4]DIAZEPIN 2 ONE; CHOLINESTERASE INHIBITOR; DIAZEPINE DERIVATIVE; EGLUMETAD; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDINE; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VIVO STUDY; LOCOMOTION; MEMORY DISORDER; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TASK PERFORMANCE; WORKING MEMORY;

ADMINISTRATION, ORAL; ANIMALS; AZEPINES; BEHAVIOR, ANIMAL; BICYCLO COMPOUNDS; BRAIN; CHOLINESTERASE INHIBITORS; DRUG SYNERGISM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; MEMORY DISORDERS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SCOPOLAMINE;

RATTUS;

EID: 78149284597     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.125     Document Type: Article

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