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Volumn 37, Issue 11, 2010, Pages 2205-2215

Pharmacologic immunomodulation and cutaneous malignancy in rheumatoid arthritis, psoriasis, and psoriatic arthritis

Author keywords

Immunosuppression; Melanoma; Psoriasis; Psoriatic arthritis; Rheumatoid arthritis; Skin cancer

Indexed keywords

ABATACEPT; ADALIMUMAB; ALEFACEPT; AZATHIOPRINE; CYCLOSPORIN; ETANERCEPT; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; METHOTREXATE; PREDNISONE; RITUXIMAB; TUMOR NECROSIS FACTOR INHIBITOR; USTEKINUMAB;

EID: 78149272887     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.100041     Document Type: Review
Times cited : (62)

References (48)
  • 1
    • 77949392974 scopus 로고    scopus 로고
    • Prevalence of a history of skin cancer in 2007: Results of an incidence-based model
    • Stern RS. Prevalence of a history of skin cancer in 2007: results of an incidence-based model. Arch Dermatol 2010;146:279-82.
    • (2010) Arch Dermatol , vol.146 , pp. 279-282
    • Stern, R.S.1
  • 3
    • 67650410937 scopus 로고    scopus 로고
    • Atlanta: American Cancer Society; [Internet. Accessed July 8, 2010.] Available from
    • American Cancer Society, Cancer Facts & Figures 2009. Atlanta: American Cancer Society; 2009. [Internet. Accessed July 8, 2010.] Available from: http://www.cancer.org/docroot/STT/STT-0.asp
    • (2009) Cancer Facts & Figures 2009
  • 4
    • 48749122862 scopus 로고    scopus 로고
    • Malignancy after solid organ transplantation: An overview
    • Zafar SY, Howell DN, Gockerman JP. Malignancy after solid organ transplantation: an overview. Oncologist 2008;13:769-78.
    • (2008) Oncologist , vol.13 , pp. 769-778
    • Zafar, S.Y.1    Howell, D.N.2    Gockerman, J.P.3
  • 5
    • 67549142546 scopus 로고    scopus 로고
    • The efficacy and toxicity of methotrexate (MTX) monotherapy vs. MTX combination therapy with non-biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis: A systematic review and metaanalysis
    • Katchamart W, Trudeau J, Phumethum V, Bombardier C. The efficacy and toxicity of methotrexate (MTX) monotherapy vs. MTX combination therapy with non-biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis: A systematic review and metaanalysis. Ann Rheum Dis 2009;68:1105-12.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1105-1112
    • Katchamart, W.1    Trudeau, J.2    Phumethum, V.3    Bombardier, C.4
  • 6
    • 36849031709 scopus 로고    scopus 로고
    • Methotrexate vs. ciclosporin in psoriasis: Effectiveness, quality of life and safety. A randomized controlled trial
    • Flytstrom I, Stenberg B, Svensson A, Bergbrant IM. Methotrexate vs. ciclosporin in psoriasis: effectiveness, quality of life and safety. A randomized controlled trial. Br J Dermatol 2008;158:116-21.
    • (2008) Br J Dermatol , vol.158 , pp. 116-121
    • Flytstrom, I.1    Stenberg, B.2    Svensson, A.3    Bergbrant, I.M.4
  • 7
    • 0034790695 scopus 로고    scopus 로고
    • A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis
    • Salvarani C, Macchioni P, Olivieri I, Marchesoni A, Cutolo M, Ferraccioli G, et al. A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. J Rheumatol 2001;28:2274-82.
    • (2001) J Rheumatol , vol.28 , pp. 2274-2282
    • Salvarani, C.1    Macchioni, P.2    Olivieri, I.3    Marchesoni, A.4    Cutolo, M.5    Ferraccioli, G.6
  • 8
    • 14244269340 scopus 로고    scopus 로고
    • Psoriatic arthritis therapy: NSAIDs and traditional DMARDs
    • Nash P, Clegg DO. Psoriatic arthritis therapy: NSAIDs and traditional DMARDs. Ann Rheum Dis 2005;64 Suppl 2:ii74-7.
    • (2005) Ann Rheum Dis , vol.64 , Issue.SUPPL. 2
    • Nash, P.1    Clegg, D.O.2
  • 9
    • 34548663890 scopus 로고    scopus 로고
    • Medical management of mild to moderate Crohn's disease: Evidence-based treatment algorithms for induction and maintenance of remission
    • Sandborn WJ, Feagan BG, Lichtenstein GR. Medical management of mild to moderate Crohn's disease: evidence-based treatment algorithms for induction and maintenance of remission. Aliment Pharmacol Ther 2007;26:987-1003.
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 987-1003
    • Sandborn, W.J.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 10
    • 27744499707 scopus 로고    scopus 로고
    • Skin cancer, rheumatoid arthritis, and tumor necrosis factor inhibitors
    • Chakravarty EF, Michaud K, Wolfe F. Skin cancer, rheumatoid arthritis, and tumor necrosis factor inhibitors. J Rheumatol 2005;32:2130-5.
    • (2005) J Rheumatol , vol.32 , pp. 2130-2135
    • Chakravarty, E.F.1    Michaud, K.2    Wolfe, F.3
  • 11
    • 70350548170 scopus 로고    scopus 로고
    • Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: Does the risk change with the time since start of treatment?
    • Askling J, van Vollenhoven RF, Granath F, Raaschou P, Fored CM, Baecklund E, et al. Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment? Arthritis Rheum 2009;60:3180-9.
    • (2009) Arthritis Rheum , vol.60 , pp. 3180-3189
    • Askling, J.1    Van Vollenhoven, R.F.2    Granath, F.3    Raaschou, P.4    Fored, C.M.5    Baecklund, E.6
  • 12
    • 45349083403 scopus 로고    scopus 로고
    • Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with methotrexate
    • Buchbinder R, Barber M, Heuzenroeder L, Wluka AE, Giles G, Hall S, et al. Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum 2008;59:794-9.
    • (2008) Arthritis Rheum , vol.59 , pp. 794-799
    • Buchbinder, R.1    Barber, M.2    Heuzenroeder, L.3    Wluka, A.E.4    Giles, G.5    Hall, S.6
  • 13
    • 27744527575 scopus 로고    scopus 로고
    • Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists
    • Askling J, Fored CM, Brandt L, Baecklund E, Bertilsson L, Feltelius N, et al. Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists. Ann Rheum Dis 2005;64:1421-6.
    • (2005) Ann Rheum Dis , vol.64 , pp. 1421-1426
    • Askling, J.1    Fored, C.M.2    Brandt, L.3    Baecklund, E.4    Bertilsson, L.5    Feltelius, N.6
  • 14
    • 34848893989 scopus 로고    scopus 로고
    • Biologic treatment of rheumatoid arthritis and the risk of malignancy: Analyses from a large US observational study
    • Wolfe F, Michaud K. Biologic treatment of rheumatoid arthritis and the risk of malignancy: analyses from a large US observational study. Arthritis Rheum 2007;56:2886-95.
    • (2007) Arthritis Rheum , vol.56 , pp. 2886-2895
    • Wolfe, F.1    Michaud, K.2
  • 15
    • 0022004061 scopus 로고
    • Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment
    • Kinlen LJ. Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. Am J Med 1985;78:44-9.
    • (1985) Am J Med , vol.78 , pp. 44-49
    • Kinlen, L.J.1
  • 16
    • 23044480038 scopus 로고    scopus 로고
    • No evidence for increased risk of cutaneous squamous cell carcinoma in patients with rheumatoid arthritis receiving etanercept for up to 5 years
    • Lebwohl M, Blum R, Berkowitz E, Kim D, Zitnik R, Osteen C, et al. No evidence for increased risk of cutaneous squamous cell carcinoma in patients with rheumatoid arthritis receiving etanercept for up to 5 years. Arch Dermatol 2005;141:861-4.
    • (2005) Arch Dermatol , vol.141 , pp. 861-864
    • Lebwohl, M.1    Blum, R.2    Berkowitz, E.3    Kim, D.4    Zitnik, R.5    Osteen, C.6
  • 17
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006;295:2275-85.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 18
    • 67549122368 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis and the risk of malignancies: A systematic review and individual patient data meta-analysis of randomised controlled trials
    • Bongartz T, Warren FC, Mines D, Matteson EL, Abrams KR, Sutton AJ. Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials. Ann Rheum Dis 2009;68:1177-83.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1177-1183
    • Bongartz, T.1    Warren, F.C.2    Mines, D.3    Matteson, E.L.4    Abrams, K.R.5    Sutton, A.J.6
  • 19
    • 67149120677 scopus 로고    scopus 로고
    • Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases
    • Burmester GR, Mease PJ, Dijkmans BA, Gordon K, Lovell D, Panaccione R, et al. Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases. Ann Rheum Dis 2009;68:1863-9.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1863-1869
    • Burmester, G.R.1    Mease, P.J.2    Dijkmans, B.A.3    Gordon, K.4    Lovell, D.5    Panaccione, R.6
  • 20
    • 78149233281 scopus 로고    scopus 로고
    • Malignancies from patients receiving etanercept across approved indications
    • [abstract]
    • Gottlieb AB, Gordon KB, Giannini EH, Mease PJ, Li J, Chi E, et al. Malignancies from patients receiving etanercept across approved indications [abstract]. Ann Rheum Dis 2008;67 Suppl II:322.
    • (2008) Ann Rheum Dis , vol.67 , Issue.SUPPL. II , pp. 322
    • Gottlieb, A.B.1    Gordon, K.B.2    Giannini, E.H.3    Mease, P.J.4    Li, J.5    Chi, E.6
  • 21
    • 33751268255 scopus 로고    scopus 로고
    • A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs
    • Klareskog L, Gaubitz M, Rodriguez-Valverde V, Malaise M, Dougados M, Wajdula J. A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs. Ann Rheum Dis 2006;65:1578-84.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1578-1584
    • Klareskog, L.1    Gaubitz, M.2    Rodriguez-Valverde, V.3    Malaise, M.4    Dougados, M.5    Wajdula, J.6
  • 22
    • 70449709528 scopus 로고    scopus 로고
    • The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-tumour necrosis factor therapy or were directly switched to abatacept: The ARRIVE trial
    • Schiff M, Pritchard C, Huffstutter JE, Rodriguez-Valverde V, Durez P, Zhou X, et al. The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-tumour necrosis factor therapy or were directly switched to abatacept: the ARRIVE trial. Ann Rheum Dis 2009;68:1708-14.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1708-1714
    • Schiff, M.1    Pritchard, C.2    Huffstutter, J.E.3    Rodriguez-Valverde, V.4    Durez, P.5    Zhou, X.6
  • 23
    • 41849120516 scopus 로고    scopus 로고
    • Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy
    • Genovese MC, Schiff M, Luggen M, Becker JC, Aranda R, Teng J, et al. Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy. Ann Rheum Dis 2008;67:547-54.
    • (2008) Ann Rheum Dis , vol.67 , pp. 547-554
    • Genovese, M.C.1    Schiff, M.2    Luggen, M.3    Becker, J.C.4    Aranda, R.5    Teng, J.6
  • 24
    • 33749365296 scopus 로고    scopus 로고
    • Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study
    • Weinblatt M, Combe B, Covucci A, Aranda R, Becker JC, Keystone E. Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study. Arthritis Rheum 2006;54:2807-16.
    • (2006) Arthritis Rheum , vol.54 , pp. 2807-2816
    • Weinblatt, M.1    Combe, B.2    Covucci, A.3    Aranda, R.4    Becker, J.C.5    Keystone, E.6
  • 25
    • 72249096209 scopus 로고    scopus 로고
    • Malignancies in the rheumatoid arthritis abatacept clinical development programme: An epidemiological assessment
    • Simon TA, Smitten AL, Franklin J, Askling J, Lacaille D, Wolfe F, et al. Malignancies in the rheumatoid arthritis abatacept clinical development programme: An epidemiological assessment. Ann Rheum Dis 2009;68:1819-26.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1819-1826
    • Simon, T.A.1    Smitten, A.L.2    Franklin, J.3    Askling, J.4    Lacaille, D.5    Wolfe, F.6
  • 28
    • 0022475652 scopus 로고
    • No association between malignant melanoma and acne or psoriasis: Results from the Western Canada Melanoma Study
    • Elwood JM, Gallagher RP, Stapleton PJ. No association between malignant melanoma and acne or psoriasis: results from the Western Canada Melanoma Study. Br J Dermatol 1986;115:573-6.
    • (1986) Br J Dermatol , vol.115 , pp. 573-576
    • Elwood, J.M.1    Gallagher, R.P.2    Stapleton, P.J.3
  • 29
    • 0033062518 scopus 로고    scopus 로고
    • Malignant tumours and psoriasis: A follow-up study
    • Frentz G, Olsen JH. Malignant tumours and psoriasis: a follow-up study. Br J Dermatol 1999;140:237-42.
    • (1999) Br J Dermatol , vol.140 , pp. 237-242
    • Frentz, G.1    Olsen, J.H.2
  • 30
    • 33845692734 scopus 로고    scopus 로고
    • A randomized comparison of continuous vs. intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis
    • Menter A, Feldman SR, Weinstein GD, Papp K, Evans R, Guzzo C, et al. A randomized comparison of continuous vs. intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis. J Am Acad Dermatol 2007;56:e1-15.
    • (2007) J Am Acad Dermatol , vol.56
    • Menter, A.1    Feldman, S.R.2    Weinstein, G.D.3    Papp, K.4    Evans, R.5    Guzzo, C.6
  • 31
    • 67651171594 scopus 로고    scopus 로고
    • Etanercept in severe, recalcitrant psoriasis: Clinical response, safety profile and predictors of response based on a single institution's experience
    • Antoniou C, Dessinioti C, Stratigos A, Avgerinou G, Stavropoulos P, Katsambas A. Etanercept in severe, recalcitrant psoriasis: clinical response, safety profile and predictors of response based on a single institution's experience. J Eur Acad Dermatol Venereol 2009;23:979-82.
    • (2009) J Eur Acad Dermatol Venereol , vol.23 , pp. 979-982
    • Antoniou, C.1    Dessinioti, C.2    Stratigos, A.3    Avgerinou, G.4    Stavropoulos, P.5    Katsambas, A.6
  • 33
    • 0034536150 scopus 로고    scopus 로고
    • Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: A critical review of the literature and meta-analysis
    • Marcil I, Stern RS. Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 2000;136:1524-30.
    • (2000) Arch Dermatol , vol.136 , pp. 1524-1530
    • Marcil, I.1    Stern, R.S.2
  • 34
    • 41949115520 scopus 로고    scopus 로고
    • Long-term follow-up of cancer risk in patients treated with short-term cyclosporine
    • Vakeva L, Reitamo S, Pukkala E, Sarna S, Ranki A. Long-term follow-up of cancer risk in patients treated with short-term cyclosporine. Acta Derm Venereol 2008;88:117-20.
    • (2008) Acta Derm Venereol , vol.88 , pp. 117-120
    • Vakeva, L.1    Reitamo, S.2    Pukkala, E.3    Sarna, S.4    Ranki, A.5
  • 35
    • 0028242317 scopus 로고
    • The carcinogenic risk of treatments for severe psoriasis. Photochemotherapy follow-up study
    • Stern RS, Laird N. The carcinogenic risk of treatments for severe psoriasis. Photochemotherapy follow-up study. Cancer 1994;73:2759-64.
    • (1994) Cancer , vol.73 , pp. 2759-2764
    • Stern, R.S.1    Laird, N.2
  • 37
    • 45849086165 scopus 로고    scopus 로고
    • A multicenter, open-label study of repeat courses of intramuscular alefacept in combination with other psoriasis therapies in patients with chronic plaque psoriasis
    • Krueger GG, Gottlieb AB, Sterry W, Korman N, van de Kerkhof P. A multicenter, open-label study of repeat courses of intramuscular alefacept in combination with other psoriasis therapies in patients with chronic plaque psoriasis. J Dermatol Treatment 2008;19:146-55.
    • (2008) J Dermatol Treatment , vol.19 , pp. 146-155
    • Krueger, G.G.1    Gottlieb, A.B.2    Sterry, W.3    Korman, N.4    Van De Kerkhof, P.5
  • 38
    • 33644542731 scopus 로고    scopus 로고
    • An integrated analysis of thirteen trials summarizing the long-term safety of alefacept in psoriasis patients who have received up to nine courses of therapy
    • Goffe B, Papp K, Gratton D, Krueger GG, Darif M, Lee S, et al. An integrated analysis of thirteen trials summarizing the long-term safety of alefacept in psoriasis patients who have received up to nine courses of therapy. Clin Ther 2005;27:1912-21.
    • (2005) Clin Ther , vol.27 , pp. 1912-1921
    • Goffe, B.1    Papp, K.2    Gratton, D.3    Krueger, G.G.4    Darif, M.5    Lee, S.6
  • 39
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Randomised, double-blind, placebo-controlled, crossover trial
    • Gottlieb A, Menter A, Mendelsohn A, Shen YK, Li S, Guzzo C, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 2009;373:633-40.
    • (2009) Lancet , vol.373 , pp. 633-640
    • Gottlieb, A.1    Menter, A.2    Mendelsohn, A.3    Shen, Y.K.4    Li, S.5    Guzzo, C.6
  • 40
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008;371:1665-74.
    • (2008) Lancet , vol.371 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6
  • 41
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M, Krueger GG, Szapary P, Yeilding N, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008;371:1675-84.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6
  • 43
    • 0033385944 scopus 로고    scopus 로고
    • The incidence of cancer associated with the treatment of rheumatoid arthritis
    • Beauparlant P, Papp K, Haraoui B. The incidence of cancer associated with the treatment of rheumatoid arthritis. Semin Arthritis Rheum 1999;29:148-58.
    • (1999) Semin Arthritis Rheum , vol.29 , pp. 148-158
    • Beauparlant, P.1    Papp, K.2    Haraoui, B.3
  • 44
    • 0029097190 scopus 로고
    • Long-term maintenance therapy with cyclosporine and posttreatment survey in severe psoriasis: Results of a multicenter study. German Multicenter Study
    • Mrowietz U, Farber L, Henneicke-von Zepelin HH, Bachmann H, Welzel D, Christophers E. Long-term maintenance therapy with cyclosporine and posttreatment survey in severe psoriasis: results of a multicenter study. German Multicenter Study. J Am Acad Dermatol 1995;33:470-5.
    • (1995) J Am Acad Dermatol , vol.33 , pp. 470-475
    • Mrowietz, U.1    Farber, L.2    Henneicke-von Zepelin, H.H.3    Bachmann, H.4    Welzel, D.5    Christophers, E.6
  • 46
    • 0021050755 scopus 로고
    • Frequency of malignant neoplasms in 248 long-term methotrexate-treated psoriatics. A preliminary study
    • Nyfors A, Jensen H. Frequency of malignant neoplasms in 248 long-term methotrexate-treated psoriatics. A preliminary study. Dermatologica 1983;167:260-1.
    • (1983) Dermatologica , vol.167 , pp. 260-261
    • Nyfors, A.1    Jensen, H.2
  • 48
    • 0019959315 scopus 로고
    • Methotrexate used for psoriasis and the risk of noncutaneous or cutaneous malignancy
    • Stern RS, Zierler S, Parrish JA. Methotrexate used for psoriasis and the risk of noncutaneous or cutaneous malignancy. Cancer 1982;50:869-72.
    • (1982) Cancer , vol.50 , pp. 869-872
    • Stern, R.S.1    Zierler, S.2    Parrish, J.A.3


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