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Volumn 95, Issue 11, 2010, Pages 1865-1872

Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Author keywords

B cell receptor; Bortezomib; Mantle cell lymphoma; STAT3

Indexed keywords

B LYMPHOCYTE RECEPTOR; BORTEZOMIB; INTERLEUKIN 10; INTERLEUKIN 6; JANUS KINASE; STAT3 PROTEIN;

EID: 78149266421     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.019745     Document Type: Article
Times cited : (56)

References (35)
  • 1
    • 33646894078 scopus 로고    scopus 로고
    • Mantle cell lymphoma: An update on management
    • Zelenetz AD. Mantle cell lymphoma: an update on management. Ann Oncol. 2006;17 (Suppl 4):iv 12-4.
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 4
    • Zelenetz, A.D.1
  • 2
    • 33750625445 scopus 로고    scopus 로고
    • Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
    • Fisher RI, Bernstein SH, Kahl BS, Djulbegovic B, Robertson MJ, de Vos S, et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2006;24(30):4867-74.
    • (2006) J Clin Oncol , vol.24 , Issue.30 , pp. 4867-4874
    • Fisher, R.I.1    Bernstein, S.H.2    Kahl, B.S.3    Djulbegovic, B.4    Robertson, M.J.5    de Vos, S.6
  • 3
    • 0012605914 scopus 로고    scopus 로고
    • Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations
    • Camacho FI, Algara P, Rodriguez A, Ruiz-Ballesteros E, Mollejo M, Martinez N, et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood. 2003;101(10):4042-6.
    • (2003) Blood , vol.101 , Issue.10 , pp. 4042-4046
    • Camacho, F.I.1    Algara, P.2    Rodriguez, A.3    Ruiz-Ballesteros, E.4    Mollejo, M.5    Martinez, N.6
  • 4
    • 10744226486 scopus 로고    scopus 로고
    • The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival
    • Martinez N, Camacho FI, Algara P, Rodriguez A, Dopazo A, Ruiz-Ballesteros E, et al. The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival. Cancer Res. 2003; 63(23):8226-32.
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 8226-8232
    • Martinez, N.1    Camacho, F.I.2    Algara, P.3    Rodriguez, A.4    Dopazo, A.5    Ruiz-Ballesteros, E.6
  • 5
    • 0037220899 scopus 로고    scopus 로고
    • Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours
    • Lai R, Rassidakis GZ, Medeiros LJ, Leventaki V, Keating M, McDonnell TJ. Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. J Pathol. 2003;199(1):84-9.
    • (2003) J Pathol , vol.199 , Issue.1 , pp. 84-89
    • Lai, R.1    Rassidakis, G.Z.2    Medeiros, L.J.3    Leventaki, V.4    Keating, M.5    McDonnell, T.J.6
  • 6
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer - new molecular targets come of age. Nature reviews 2004;4(2):97-105.
    • (2004) Nature Reviews , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 7
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11): 798-809.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 8
    • 34250658084 scopus 로고    scopus 로고
    • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
    • Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci USA. 2007;104(18): 7391-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.18 , pp. 7391-7396
    • Siddiquee, K.1    Zhang, S.2    Guida, W.C.3    Blaskovich, M.A.4    Greedy, B.5    Lawrence, H.R.6
  • 9
    • 0033874078 scopus 로고    scopus 로고
    • Mantle cell lymphoma proliferates upon IL-10 in the CD40 system
    • Visser HP, Tewis M, Willemze R, Kluin-Nelemans JC. Mantle cell lymphoma proliferates upon IL-10 in the CD40 system. Leukemia. 2000;14(8):1483-9.
    • (2000) Leukemia , vol.14 , Issue.8 , pp. 1483-1489
    • Visser, H.P.1    Tewis, M.2    Willemze, R.3    Kluin-Nelemans, J.C.4
  • 10
    • 0030946515 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, selfrenewing B-1 cells but only inducibly expressed in conventional B lymphocytes
    • Karras JG, Wang Z, Huo L, Howard RG, Frank DA, Rothstein TL. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, selfrenewing B-1 cells but only inducibly expressed in conventional B lymphocytes. J Exp Med. 1997;185(6):1035-42.
    • (1997) J Exp Med , vol.185 , Issue.6 , pp. 1035-1042
    • Karras, J.G.1    Wang, Z.2    Huo, L.3    Howard, R.G.4    Frank, D.A.5    Rothstein, T.L.6
  • 11
    • 0035107898 scopus 로고    scopus 로고
    • Lymphokine dependence of STAT3 activation produced by surface immunoglobulin cross-linking and by phorbol ester plus calcium ionophore treatment in B cells
    • Fan H, Rothstein TL. Lymphokine dependence of STAT3 activation produced by surface immunoglobulin cross-linking and by phorbol ester plus calcium ionophore treatment in B cells. Eur J Immunol. 2001;31(2): 665-71.
    • (2001) Eur J Immunol , vol.31 , Issue.2 , pp. 665-671
    • Fan, H.1    Rothstein, T.L.2
  • 12
    • 34247866419 scopus 로고    scopus 로고
    • Engagement of the B-cell antigen receptor activates STAT through Lyn in a Jak-independent pathway
    • Wang L, Kurosaki T, Corey SJ. Engagement of the B-cell antigen receptor activates STAT through Lyn in a Jak-independent pathway. Oncogene. 2007;26(20):2851-9.
    • (2007) Oncogene , vol.26 , Issue.20 , pp. 2851-2859
    • Wang, L.1    Kurosaki, T.2    Corey, S.J.3
  • 13
    • 0037114620 scopus 로고    scopus 로고
    • Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production
    • Gary-Gouy H, Harriague J, Bismuth G, Platzer C, Schmitt C, Dalloul AH. Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production. Blood. 2002;100(13):4537-43.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4537-4543
    • Gary-Gouy, H.1    Harriague, J.2    Bismuth, G.3    Platzer, C.4    Schmitt, C.5    Dalloul, A.H.6
  • 15
    • 33746924345 scopus 로고    scopus 로고
    • Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression
    • Deglesne PA, Chevallier N, Letestu R, Baran-Marszak F, Beitar T, Salanoubat C, et al. Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res. 2006;66(14): 7158-66.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7158-7166
    • Deglesne, P.A.1    Chevallier, N.2    Letestu, R.3    Baran-Marszak, F.4    Beitar, T.5    Salanoubat, C.6
  • 16
    • 33746238516 scopus 로고    scopus 로고
    • IGHV gene insertions and deletions in chronic lymphocytic leukemia: CLLbiased deletions in a subset of cases with stereotyped receptors
    • Belessi CJ, Davi FB, Stamatopoulos KE, Degano M, Andreou TM, Moreno C, et al. IGHV gene insertions and deletions in chronic lymphocytic leukemia: CLLbiased deletions in a subset of cases with stereotyped receptors. Eur J Immunol. 2006;36(7):1963-74.
    • (2006) Eur J Immunol , vol.36 , Issue.7 , pp. 1963-1974
    • Belessi, C.J.1    Davi, F.B.2    Stamatopoulos, K.E.3    Degano, M.4    Andreou, T.M.5    Moreno, C.6
  • 17
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: A small-molecule inhibitor of STAT3 activation and dimerization
    • Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13(11):1235-42.
    • (2006) Chem Biol , vol.13 , Issue.11 , pp. 1235-1242
    • Schust, J.1    Sperl, B.2    Hollis, A.3    Mayer, T.U.4    Berg, T.5
  • 18
    • 33846530661 scopus 로고    scopus 로고
    • A phase II study of bortezomib in mantle cell lymphoma: The National Cancer Institute of Canada Clinical Trials Group trial IND.150
    • Belch A, Kouroukis CT, Crump M, Sehn L, Gascoyne RD, Klasa R, et al. A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150. Ann Oncol 2007;18(1):116-21.
    • (2007) Ann Oncol , vol.18 , Issue.1 , pp. 116-121
    • Belch, A.1    Kouroukis, C.T.2    Crump, M.3    Sehn, L.4    Gascoyne, R.D.5    Klasa, R.6
  • 19
    • 78149249825 scopus 로고    scopus 로고
    • Interim results of the RiPAD+C regimen including velcade in front line therapy for elderly patients with mantle cell lymphoma. A phase II prospective study of the GOELAMS group
    • Gressin R, Caulet Maugendre S, Le Gouill S, Ojeda Uribe M, Alexis Vigier M, Bouabdallah K, et al. Interim results of the RiPAD+C regimen including velcade in front line therapy for elderly patients with mantle cell lymphoma. A phase II prospective study of the GOELAMS group. Blood. (ASH Annual Meeting Abstracts) 2008;112:1575.
    • (2008) Blood. (ASH Annual Meeting Abstracts) , vol.112 , pp. 1575
    • Gressin, R.1    Caulet Maugendre, S.2    le Gouill, S.3    Ojeda Uribe, M.4    Alexis Vigier, M.5    Bouabdallah, K.6
  • 20
    • 34250199957 scopus 로고    scopus 로고
    • New directions in the treatment of mantle cell lymphoma: An overview
    • Goy A. New directions in the treatment of mantle cell lymphoma: an overview. Clin Lymphoma Myeloma. 2006;7 (Suppl 1): S24-32.
    • (2006) Clin Lymphoma Myeloma , vol.7 , Issue.SUPPL. 1
    • Goy, A.1
  • 21
    • 0038206722 scopus 로고    scopus 로고
    • Inhibition of constitutive NFkappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
    • Pham LV, Tamayo AT, Yoshimura LC, Lo P, Ford RJ. Inhibition of constitutive NFkappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol. 2003;171(1):88-95.
    • (2003) J Immunol , vol.171 , Issue.1 , pp. 88-95
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lo, P.4    Ford, R.J.5
  • 22
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-kappa;B pathways in subtypes of diffuse large Bcell lymphoma
    • Lam LT, Wright G, Davis RE, Lenz G, Farinha P, Dang L, et al. Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-kappa;B pathways in subtypes of diffuse large Bcell lymphoma. Blood. 2008;111(7):3701-13.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3701-3713
    • Lam, L.T.1    Wright, G.2    Davis, R.E.3    Lenz, G.4    Farinha, P.5    Dang, L.6
  • 23
    • 2442684327 scopus 로고    scopus 로고
    • Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: Pivotal role of p38 MAPK in drug resistance
    • Vega MI, Huerta-Yepaz S, Garban H, Jazirehi A, Emmanouilides C, Bonavida B. Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance. Oncogene. 2004;23(20):3530-40.
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3530-3540
    • Vega, M.I.1    Huerta-Yepaz, S.2    Garban, H.3    Jazirehi, A.4    Emmanouilides, C.5    Bonavida, B.6
  • 24
    • 33749055594 scopus 로고    scopus 로고
    • Molecular crosstalk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
    • Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr, Gutkind JS. Molecular crosstalk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006;8(9): 733-46.
    • (2006) Neoplasia , vol.8 , Issue.9 , pp. 733-746
    • Squarize, C.H.1    Castilho, R.M.2    Sriuranpong, V.3    Pinto Jr., D.S.4    Gutkind, J.S.5
  • 25
    • 3142554015 scopus 로고    scopus 로고
    • Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms
    • Dai Y, Rahmani M, Pei XY, Dent P, Grant S. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood. 2004;104(2):509-18.
    • (2004) Blood , vol.104 , Issue.2 , pp. 509-518
    • Dai, Y.1    Rahmani, M.2    Pei, X.Y.3    Dent, P.4    Grant, S.5
  • 26
    • 33750292098 scopus 로고    scopus 로고
    • Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: Mutated genotype correlates with better clinical outcome
    • Lai R, Lefresne SV, Franko B, Hui D, Mirza I, Mansoor A, et al. Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome. Mod Pathol. 2006;19(11):1498-505.
    • (2006) Mod Pathol , vol.19 , Issue.11 , pp. 1498-1505
    • Lai, R.1    Lefresne, S.V.2    Franko, B.3    Hui, D.4    Mirza, I.5    Mansoor, A.6
  • 27
    • 0141889260 scopus 로고    scopus 로고
    • VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: Correlation with genomic aberrations, clinical characteristics, and outcome
    • Kienle D, Krober A, Katzenberger T, Ott G, Leupolt E, Barth TF, et al. VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood. 2003;102(8): 3003-9.
    • (2003) Blood , vol.102 , Issue.8 , pp. 3003-3009
    • Kienle, D.1    Krober, A.2    Katzenberger, T.3    Ott, G.4    Leupolt, E.5    Barth, T.F.6
  • 28
    • 2342459649 scopus 로고    scopus 로고
    • Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders
    • Letestu R, Ugo V, Valensi F, Radford-Weiss I, Nataf J, Levy V, et al. Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders. Leukemia. 2004;18(5):953-61.
    • (2004) Leukemia , vol.18 , Issue.5 , pp. 953-961
    • Letestu, R.1    Ugo, V.2    Valensi, F.3    Radford-Weiss, I.4    Nataf, J.5    Levy, V.6
  • 30
    • 0037588965 scopus 로고    scopus 로고
    • Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma
    • Walsh SH, Thorselius M, Johnson A, Soderberg O, Jerkeman M, Bjorck E, et al. Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood. 2003;101(10):4047-54.
    • (2003) Blood , vol.101 , Issue.10 , pp. 4047-4054
    • Walsh, S.H.1    Thorselius, M.2    Johnson, A.3    Soderberg, O.4    Jerkeman, M.5    Bjorck, E.6
  • 31
    • 10744227172 scopus 로고    scopus 로고
    • A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease
    • Orchard J, Garand R, Davis Z, Babbage G, Sahota S, Matutes E, et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood. 2003;101(12): 4975-81.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4975-4981
    • Orchard, J.1    Garand, R.2    Davis, Z.3    Babbage, G.4    Sahota, S.5    Matutes, E.6
  • 32
    • 17844368292 scopus 로고    scopus 로고
    • B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma
    • Mizuno T, Rothstein TL. B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma. J Immunol. 2005;174(10):6062-70.
    • (2005) J Immunol , vol.174 , Issue.10 , pp. 6062-6070
    • Mizuno, T.1    Rothstein, T.L.2
  • 33
    • 0033527716 scopus 로고    scopus 로고
    • Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19
    • Su L, Rickert RC, David M. Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J Biol Chem. 1999;274(45):31770-4.
    • (1999) J Biol Chem , vol.274 , Issue.45 , pp. 31770-31774
    • Su, L.1    Rickert, R.C.2    David, M.3
  • 34
    • 33750827521 scopus 로고    scopus 로고
    • Cutting edge: Inherent and acquired resistance to radiation-induced apoptosis in B cells: A pivotal role for STAT3
    • Otero DC, Poli V, David M, Rickert RC. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol. 2006;177(10):6593-7.
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 6593-6597
    • Otero, D.C.1    Poli, V.2    David, M.3    Rickert, R.C.4
  • 35
    • 0030587087 scopus 로고    scopus 로고
    • Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes
    • Karras JG, Huo L, Wang Z, Frank DA, Zimmet JM, Rothstein TL. Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes. J Immunol. 1996;157(6):2299-309.
    • (1996) J Immunol , vol.157 , Issue.6 , pp. 2299-2309
    • Karras, J.G.1    Huo, L.2    Wang, Z.3    Frank, D.A.4    Zimmet, J.M.5    Rothstein, T.L.6


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