Immunophenotypic correlation between skin biopsy and peripheral blood findings in mycosis fungoides

American Journal of Clinical Pathology

Volumn 134, Issue 5, 2010, Pages 739-748

  Kelemen, Katalin ^a   White, Clifton R ^b   Gatter, Ken ^a   Braziel, Rita M ^a   Fan, Guang ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Flow cytometry; Immunohistochemistry; Mycosis fungoides; T cell immunophenotype

Indexed keywords

CD2 ANTIGEN; CD3 ANTIGEN; CD5 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; MYCOSIS FUNGOIDES; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN BIOPSY; T LYMPHOCYTE; BLOOD; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; SKIN; SKIN TUMOR;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; MYCOSIS FUNGOIDES; POLYMERASE CHAIN REACTION; SKIN; SKIN NEOPLASMS; T-LYMPHOCYTES;

EID: 78049521006     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCP7LRRLK8SLUGE     Document Type: Article

References (31)

1. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768-3785.
2. Shapiro PE, Pinto FJ. The histologic spectrum of mycosis fungoides/Sézary syndrome (cutaneous T-cell lymphoma): a review of 222 biopsies, including newly described patterns and the earliest pathologic changes. Am J Surg Pathol. 1994;18:645-667.
3. Nashan D, Faulhaber D, Stander S, et al. Mycosis fungoides: a dermatological masquerader. Br J Dermatol. 2007;156:1-10.
4. Kelemen K, Guitart J, Kuzel TM, et al. The usefulness of CD26 in flow cytometric analysis of peripheral blood in Sézary syndrome. Am J Clin Pathol. 2008;129:146-156. (Pubitemid 352038603)
5. Harmon CB, Witzig TE, Katzmann JA, et al. Detection of circulating T cells with CD4+CD7- immunophenotype in patients with benign and malignant lymphoproliferative dermatoses. J Am Acad Dermatol. 1996;35:404-410. (Pubitemid 126690419)
6. Muche JM, Lukowsky A, Asadullah K, et al. Demonstration of frequent occurrence of clonal T cells in the peripheral blood of patients with primary cutaneous T-cell lymphoma. Blood. 1997;90:1636-1642. (Pubitemid 27355437)
7. Delfau-Larue MH, Laroche L, Wechsler J, et al. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood. 2000;96:2987-2992.
8. Smoller BR, Bishop K, Glusac E, et al. Reassessment of histologic parameters in the diagnosis of mycosis fungoides. Am J Surg Pathol. 1995;19:1423-1430.
9. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.
10. Sprouse JT, Werling R, Hanke D, et al. T-cell clonality determination using polymerase chain reaction (PCR) amplification of the T-cell receptor gamma-chain gene and capillary electrophoresis of fluorescently labeled PCR products. Am J Clin Pathol. 2000;113:838-850.
11. Burg G, Zwingers T, Staegemeir E, et al, for the EORTC-Cutaneous Lymphoma Project Group. Interrater and intrarater variabilities in the evaluation of cutaneous lymphoproliferative T-cell infiltrates. Dermatol Clin. 1994;12:311-314.
12. Lefeber WP, Robinson JK, Clendenning WE, et al. Attempts to enhance light microscopic diagnosis of cutaneous T-cell lymphoma (mycosis fungoides). Arch Dermatol. 1981;117:408-411.
13. Santucci M, Burg G, Feller AC. Interrater and intrarater reliability of histologic criteria in early cutaneous T-cell lymphoma: an EORTC Cutaneous Lymphoma Project Group study. Dermatol Clin. 1994;12:323-327. (Pubitemid 24149716)
14. Ming M, LeBoit PE. Can dermatopathologists reliably make the diagnosis of mycosis fungoides? if not, who can? Arch Dermatol. 2000;136:543-546. (Pubitemid 30212969)
15. Florell SR, Cessna M, Lundell RB, et al. Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates. Am J Clin Pathol. 2006;125:727-736.
16. Lindae ML, Abel EA, Hoppe RT, et al. Poikilodermatous mycosis fungoides and atrophic large-plaque parapsoriasis exhibit similar abnormalities of T-cell antigen expression. Arch Dermatol. 1988;124:366-372.
17. Ormsby A, Bergfeld WF, Tubbs RR, et al. Evaluation of a new paraffin-reactive CD7 T-cell deletion marker and a polymerase chain reaction-based T-cell receptor gene rearrangement assay: implications for diagnosis of mycosis fungoides in community clinical practice. J Am Acad Dermatol. 2001;45:405-413. (Pubitemid 32800498)
18. Furmanczyk PS, Wolgamot GM, Kussick SJ, et al. Diagnosis of mycosis fungoides with different algorithmic approaches [published online ahead of print July 7, 2009]. J Cutan Pathol. 2010;37:8-14. doi:10.1111/j.1600-0560.2009. 01289.x.
19. Bakels V, van Oostveen JW, van der Putte SC, et al. Immunophenotyping and gene rearrangement analysis provide additional criteria to differentiate between cutaneous T-cell lymphomas and pseudo-T-cell lymphomas. Am J Pathol. 1997;150:1941-1949.
20. Vonderheid EC, Sobel EL, Nowell PC, et al. Diagnostic and prognostic significance of Sézary cells in peripheral blood smears from patients with cutaneous T cell lymphoma. Blood. 1985;66:358-366.
21. Schechter GP, Sausville EA, Fischmann AB, et al. Evaluation of circulating malignant cells provides prognostic information in cutaneous T cell lymphoma. Blood. 1987;69:841-849.
22. β chain antibodies and its application in blood staging. Mod Pathol. 2010;23:284-295.
23. Michie SA, Abel EA, Hoppe RT, et al. Discordant expression of antigens between intraepidermal and intradermal T cells in mycosis fungoides. Am J Pathol. 1990;137:1447-1451.
24. Berger CL, Warburton D, Raafat J, et al. Cutaneous T-cell lymphoma: neoplasm of T cells with helper activity. Blood. 1979;53:642-651. (Pubitemid 9148999)
25. Massone C, Crisman G, Kerl H, et al. The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality. Br J Dermatol. 2008;159:881-886.
26. Nuckols JD, Shea CR, Horenstein MG, et al. Quantitation of intraepidermal T-cell subsets in formalin-fixed, paraffin-embedded tissue helps in the diagnosis of mycosis fungoides. J Cutan Pathol. 1999;26:169-175.
27. Vega F, Luthra R, Medeiros LJ, et al. Clonal heterogeneity in mycosis fungoides and its relationship to clinical course. Blood. 2002;100:3369-3373.
28. Thurber SE, Zhang B, Kim YH, et al. T-cell clonality analysis in biopsy specimens from two different skin sites shows high specificity in the diagnosis of patients with suggested mycosis fungoides. J Am Acad Dermatol. 2007;57:782-790.
29. Fraser-Andrews EA, Woolford AJ, Russell-Jones R, et al. Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides. J Invest Dermatol. 2000;114:117-121. (Pubitemid 30195983)
30. Muche JM, Sterry W, Gellrich S, et al. Peripheral blood T-cell clonality in mycosis fungoides and nonlymphoma controls. Diagn Mol Pathol. 2003;12:142-150. (Pubitemid 37040601)
31. Wood GS. Analysis of clonality in cutaneous T cell lymphoma and associated diseases. Ann N Y Acad Sci. 2001;941:26-30.