Flow cytometric detection of peripheral blood involvement by mycosis fungoides and Sézary syndrome using T-cell receptor VΒ chain antibodies and its application in blood staging

Modern Pathology

Volumn 23, Issue 2, 2010, Pages 284-295

  Feng, Bo ^a   Jorgensen, Jeffrey L ^a   Jones, Dan ^a   Chen, Su S ^a   Hu, Ying ^a   Medeiros, L Jeffrey ^a   Wang, Sa A ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Flow cytometry immunophenotyping; Mycosis fungoides; S zary syndrome; T cell receptor gene rearrangement; T cell receptor Vb

Indexed keywords

T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TUMOR ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CELL CLONE; CELL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; GENE; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MYCOSIS FUNGOIDES; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SEZARY SYNDROME; T LYMPHOCYTE;

EID: 76349099136     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.175     Document Type: Article

References (37)

1. Taswell HF, Winkelmann RK. Sezary syndrome-a malignant reticulemic erythroderma. JAMA 1961;177:465-472.
2. Lamberg SI, Diamond EL, Lorincz AL, et al. Mycosis fungoides cooperative study. Arch Dermatol 1975; 111:3.
3. Kim YH, Liu HL, Mraz-Gernhard S, et al. Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progression. Arch Dermatol 2003;139: 857-866.
4. Scarisbrick JJ, Whittaker S, Evans AV, et al. Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lympho-ma. Blood 2001;97:624-630.
5. Schechter GP, Sausville EA, Fischmann AB, et al. Evaluation of circulating malignant cells provides prognostic information in cutaneous T cell lymphoma. Blood 1987;69:841-849.
6. Olsen E, Vonderheid E, Pimpinelli N, et al. Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 2007;110:1713-1722.
7. Lutzner MA, Hobbs JW, Horvath P. Ultrastructure of abnormal cells: in Sezary syndrome, mycosis fungoides, and parapsoriasis en plaque. Arch Dermatol 1971;103:375-386.
8. Lutzner MA, Emerit I, Durepaire R, et al. Cytogenetic, cytophotometric, and ultrastructural study of large cerebriform cells of the Sezary syndrome and description of a small-cell variant. J Natl Cancer Inst 1973;50:1145-1162.
9. van der Loo EM, Cnossen J, Meijer CJ. Morphological aspects of T cell subpopulations in human blood: characterization of the cerebriform mononuclear cells in healthy individuals. Clin Exp Immunol 1981;43: 506-516.
10. Duncan SC, Winkelmann RK. Circulating Sezary cells in hospitalized dermatology patients. Br J Dermatol 1978;99:171-178.
11. Bernengo MG, Novelli M, Quaglino P, et al. The relevance of the CD4+ CD26-subset in the identification of circulating Sezary cells. Br J Dermatol 2001;144: 125-135.
12. Borowitz MJ, Weidner A, Olsen EA, et al. Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. Leukemia 1993;7:859-863.
13. Klemke CD, Brade J, Weckesser S, et al. The diagnosis of Sezary syndrome on peripheral blood by flow cytometry requires the use of multiple markers. Br J Dermatol 2008;159:871-880.
14. Jones D, Dang NH, Duvic M, et al. Absence of CD26 expression is a useful marker for diagnosis of T-cell lymphoma in peripheral blood. Am J Clin Pathol 2001;115:885-892.
15. Wang S, Li N, Heald P, et al. Flow cytometric DNA ploidy analysis of peripheral blood from patients with sezary syndrome: detection of aneuploid neoplastic T cells in the blood is associated with large cell transformation in tissue. Am J Clin Pathol 2004;122: 774-782.
16. Rappl G, Muche JM, Abken H, et al. CD4(+)CD7(-) T cells compose the dominant T-cell clone in the peripheral blood of patients with Sezary syndrome. J Am Acad Dermatol 2001;44:456-461.
17. Harmon CB, Witzig TE, Katzmann JA, Pittelkow MR. Detection of circulating T cells with CD4+CD7-immunophenotype in patients with benign and malignant lymphoproliferative dermatoses. J Am Acad Dermatol 1996;35:404-410.
18. Pierson DM, Jones D, Muzzafar T, et al. Utility of CD26 in flow cytometric immunophenotyping of T-cell lymphomas in tissue and body fluid specimens. Cytometry B Clin Cytom 2008;74:341-348.
19. Ponti R, Quaglino P, Novelli M, et al. T-cell receptor gamma gene rearrangement by multiplex polymerase chain reaction/heteroduplex analysis in patients with cutaneous T-cell lymphoma (mycosis fungoides/Sezary syndrome) and benign inflammatory disease: correlation with clinical, histological and immunophenotypical findings. Br J Dermatol 2005;153:565-573.
20. Posnett DN, Sinha R, Kabak S, et al. Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy' [published erratum appears in J Exp Med 1994;179:1077]. J Exp Med 1994;179:609-618.
21. Muche JM, Sterry W, Gellrich S, et al. Peripheral blood T-cell clonality in mycosis fungoides and nonlympho-ma controls. Diagn Mol Pathol 2003;12:142-150.
22. Muche JM, Lukowsky A, Asadullah K, et al. Demonstration of frequent occurrence of clonal T cells in the peripheral blood of patients with primary cutaneous T-cell lymphoma. Blood 1997;90:1636-1642.
23. Weinberg JM, Jaworsky C, Benoit BM, et al. The clonal nature of circulating Sezary cells [published erratum appears in Blood 1996;87:4923]. Blood 1995;86: 4257-4262.
24. Gniadecki R, Lukowsky A. Monoclonal T-cell dyscra-sia of undetermined significance associated with recalcitrant erythroderma. Arch Dermatol 2005;141: 361-367.
25. Schwab C, Willers J, Niederer E, et al. The use of anti-T-cell receptor-Vbeta antibodies for the estimation of treatment success and phenotypic characterization of clonal T-cell populations in cutaneous T-cell lympho-mas. Br J Haematol 2002;118:1019-1026.
26. Langerak AW, van Den Beemd R, Wolvers-Tettero IL, et al. Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalpha-beta T-cell proliferations. Blood 2001;98:165-173.
27. Lima M, Almeida J, dos Anjos Teixeira M, et al. Utility of flow cytometry immunophenotyping and DNA ploidy studies for diagnosis and characterization of blood involvement in CD4+ Sezary's syndrome. Hae-matologica 2003;88:874-887.
28. Morice WG, Katzmann JA, Pittelkow MR, el-Azhary RA, Gibson LE, Hanson CA. A comparison of morphologic features, flow cytometry, TCR-Vbeta analysis, and TCR-PCR in qualitative and quantitative assessment of peripheral blood involvement by Sezary syndrome. Am J Clin Pathol 2006;125:364-374.
29. Ortonne N, Huet D, Gaudez C, et al. Significance of circulating T-cell clones in Sezary syndrome. Blood 2006;107:4030-4038.
30. Morice WG, Kimlinger T, Katzmann JA, et al. Flow cytometric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: a comparison with conventional T-cell immunophenotyping and molecular genetic techniques. Am J Clin Pathol 2004;121: 373-383.
31. van den Beemd R, Boor PP, van Lochem EG, et al. Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 2000;40:336-345.
32. Vega F, Medeiros LJ, Jones D, et al. A novel four-color PCR assay to assess T-cell receptor gamma gene rearrangements in lymphoproliferative lesions. Am J Clin Pathol 2001;116:17-24.
33. Droese J, Langerak AW, Groenen PJ, et al. Validation of BIOMED-2 multiplex PCR tubes for detection of TCRB gene rearrangements in T-cell malignancies. Leukemia 2004;18:1531-1538.
34. Wood GS, Hong SR, Sasaki DT, et al. Leu-8/CD7 antigen expression by CD3+ T cells: comparative analysis of skin and blood in mycosis fungoides/ Sezary syndrome relative to normal blood values. J Am Acad Dermatol 1990;22:602-607.
35. Abel EA, Lindae ML, Hoppe RT, et al. Benign and malignant forms of erythroderma: cutaneous immuno-phenotypic characteristics. J Am Acad Dermatol 1988;19:1089-1095.
36. Vega F, Luthra R, Medeiros LJ, et al. Clonal heterogeneity in mycosis fungoides and its relationship to clinical course. Blood 2002;100:3369-3373.
37. Yawalkar N, Ferenczi K, Jones DA, et al. Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood 2003;102:4059-4066.