Effects of intra-uterine and early extra-uterine malnutrition on seizure threshold and hippocampal morphometry of pup rats

Nutritional Neuroscience

Volumn 13, Issue 6, 2010, Pages 265-273

  Florian, Mariana Lorenzet ^a   Nunes, Magda Lahorgue ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

early malnutrition; hippocampus; morphometry; rodent model; seizure

Indexed keywords

FLUROTHYL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN REGION; BRAIN WEIGHT; CELL COUNT; CELL DENSITY; CONTROLLED STUDY; DENTATE GYRUS; DEVELOPMENT; ECTOPIC PREGNANCY; EXTRAUTERINE MALNUTRITION; FEMALE; GRANULAR CELL; HIPPOCAMPUS; INTRAUTERINE NUTRITION DEFICIENCY; JUVENILE ANIMAL; LACTATION; MALE; MALNUTRITION; MORPHOMETRICS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SEIZURE THRESHOLD;

ANIMALS; BRAIN; CELL COUNT; CONVULSANTS; FEMALE; FLUROTHYL; HIPPOCAMPUS; LACTATION; MALE; MALNUTRITION; MATERNAL-FETAL EXCHANGE; NEURONS; ORGAN SIZE; PREGNANCY; PREGNANCY COMPLICATIONS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEIZURES;

ANIMALIA; RATTUS; RODENTIA;

EID: 78049516743     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/147683010X12611460764804     Document Type: Article

References (68)

1. Monte CMG. Desnutriçao: um desafio secular à nutriçao infantil. J Pediatr (Rio J) 2000;76:285-297.
2. Dobbing J. The influence of early nutrition on the development and myelination of the brain. Proc R Soc Lond B Biol Sci 1964;159:503-509.
3. Dickerson JW, Dobbing J. Some peculiarities of cerebellar growth in pigs. Proc R Soc Med 1966;59:1088.
4. Morgane PJ, Austin-LaFrance R, Bronzino J et al. Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev 1993;17:91-128.
5. Rodriguez OTS, Szarfarc SC, Benicio MHA. Anemia e desnutriçao maternas e sua relaçao com o peso ao nascer. Saude Publica 1991;25:193-197.
6. Siqueira AAF, Tanaka ACA, Junior CC et al. A utilizaçao de uma curva ponderal de gestantes normais no diagnostico de desnutri çao intra-uterina. Saude Publica 1975;9.
7. Diaz-Cintra S, Cintra L, Ortega A et al. Effects of protein deprivation on pyramidal cells of the visual cortex in rats of three age groups. J Comp Neurol 1990;292:117-126.
8. Jordan TC, Howells KF, McNaughton N et al. Effects of early undernutrition on hippocampal development and function. Res Exp Med (Berl) 1982;180:201-207.
9. Nunes ML, Teixeira CG, Fabris I et al. Evaluation of the nutritional status in institutionalized children and its relationship to the development of epilepsy. Nutr Neurosci 1999;2:139-145.
10. Nunes ML, Liptakova S, Veliskova J et al. Malnutrition increases dentate granule cell proliferation in immature rats after status epilepticus. Epilepsia 2000;41:48-52.
11. Bronzino JD, Austin-Lafrance RJ, Siok CJ et al. Effect of protein malnutrition on hippocampal kindling: electrographic and behavioral measures. Brain Res 1986;384:348-354.
12. Gietzen DW, Dixon KD, Truong BG et al. Indispensable amino acid deficiency and increased seizure susceptibility in rats. Am J Physiol 1996;271: R18-R24.
13. Stern WC, Forbes WB, Resnick O et al. Seizure susceptibility and brain amine levels following protein malnutrition during development in the rat. Brain Res 1974;79:375-384.
14. Sharma SK, Selvamurthy W, Maheshwari MC et al. Kainic acid induced epileptogenesis in developing normal and undernourished rats - a computerised EEG analysis. Indian J Med Res 1990;92:456-466.
15. Sharma SK, Behari M, Maheshwari MC et al. Seizure susceptibility and intra rectal sodium valproate induced recovery in developing undernourished rats. Indian J Med Res 1990;92:120-127.
16. Morgane PJ, Austin K, Siok C et al. Power spectral analysis of hippocampal and cortical EEG activity following severe prenatal protein malnutrition in the rat. Brain Res 1985;354:211-218.
17. Lopes DK. Consideraçoes éticas e legais sobre utilizaçao de animais em experimentaçao científica. J Liga Bras Epilepsia 1992;5:19-22.
18. Gurmini J, Cecilio WAC, Schuler SL et al. Desnutriçao intra-uterina e suas alteraçoes no intestino delgado de ratos Wistar ao nascimento e apos a lactaçao. J Bras Patol Med Lab 2005;41:271-278.
19. Hoffmann M, Schmitt F. Cognitive impairment in isolated subtentorial stroke. Acta Neurol Scand 2004;109:14-24.
20. Boukhezra O, Riviello P, Fu DD et al. Effect of the postictal state on visual-spatial memory in immature rats. Epilepsy Res 2003;55:165-175.
21. Gundersen HJG, Jensen EB. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147:229-263.
22. Paxinos G, Watson C. The rat brain in stereotaxic coordinates, volume 4. San Diego, CA: Academic Press, 1998.
23. Lorente de No R. Studies on the structure of the cerebral cortex. Continuation of the study of the ammonic system. J Psychol Neurol 1934;46:113-177.
24. Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1998;96:379-394.
25. Schmitz C, Hof PR. Design-based stereology in neuroscience. Neuroscience 2005;130:813-831.
26. Howard C, Reed MG. Unbiased Stereology. Bios Scientific Publishers, 1998.
27. Mandarin-de-Lacerda CA. Métodos Quantitativos em Morfologia. Editora da Universidade do Estado do Rio de Janeiro, 1995.
28. Mandarin-de-Lacerda CA. Stereological tools in biomedical research. Anais da Academia brasileira de Ciências 2003;75:469-486.
29. West MJ, Gundersen HJG. Unbiased setereological estimation of the number of neurone in the human hippocampus. J Comp Neurol 1990;296:1-22.
30. Nunes M, Batista B, Micheli F et al. Effects of early malnutrition and nutritional rehabilitation in rats. J Pediatr (Rio J) 2002;78:39-44.
31. Lister JP, Tonkiss J, Blatt GJ et al. Asymmetry of neuron numbers in the hippocampal formation of prenatally malnourished and normally nourished rats: a stereological investigation. Hippocampus 2006;16:946-958.
32. Debassio W, Kemper TL, Tonkiss J et al. Effect of prenatal protein deprivation on posnatal granule cell generation in hippocampal dentate gyrus. Brain Res Bull 1996;41:379-383.
33. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992;35:595-601.
34. Seitelberger F, Lassmann H, Hornykiewicz O. Some mechanisms of brain edema studied in a kainic acid model. Acta Neurobiol Exp (Wars) 1990;50:263-267.
35. Fountain NB. Status epilepticus: risk factors and complications. Epilepsia 2000;41(Suppl 2): S23-S30.
36. Bengzon J, Kokaia Z, Elmér E et al. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc Natl Acad Sci USA 1997;94:10432-10437.
37. Parent JM. The role of seizure-induced neurogenesis in epileptogenesis and brain repair. Epilepsy Res 2002;50:179-189.
38. Scott BW, Wang S, Burnham WM et al. Kindling-induced neurogenesis in the dentate gyrus of the rat. Neurosci Lett 1998;248:73-76.
39. Gray WP, Sundstrom LE. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res 1998;790:52-59.
40. Sankar R, Shin D, Liu H et al. Granule cell neurogenesis after status epilepticus in the immature rat brain. Epilepsia 2000; (41 Suppl 6): S53-S56.
41. Porter BE, Maronski M, Brooks-Kayal AR. Fate of newborn dentate granule cells after early life status epilepticus. Epilepsia 2004;45:13-19.
42. McCabe BK, Silveira DC, Cilio MR et al. Reduced neurogenesis after neonatal seizures. J Neurosci 2001;21:2094-2103.
43. Liu H, Kaur J, Dashtipour K et al. Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid level. Exp Neurol 2003;184:196-213.
44. Nakagawa E, Aimi Y, Yasuhara O et al. Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy. Epilepsia 2000;41:10-18.
45. Zhang LX, Levine S, Dent G et al. Maternal deprivation increases cell death in the infant rat brain. Brain Res Dev Brain Res 2002;133:1-11.
46. King RS, DeBassio WA, Kemper TL et al. Effects of prenatal protein malnutrition and acute postnatal stress on granule cell genesis in the fascia dentata of neonatal and juvenile rats. Brain Res Dev Brain Res 2004;150:9-15.
47. Mirescu C, Peters JD, Gould E. Early life experience alters response of adult neurogenesis to stress. Nat Neurosci 2004;7:841-846.
48. Schoenfeld NM, Leathem JH, Rabii J. Maturation of adrenal stress responsiveness in the rat. Neuroendocrinology 1980;31:101-105.
49. Sapolsky RM, Meaney MJ. Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period. Brain Res 1986;396:64-76.
50. Bohn MC. Granule cell genesis in the hippocampus of rats treated neonatally with hydrocortisone. Neuroscience 1980;5:2003-2012.
51. Bohn MC, Lauder JM. Cerebellar granule cell genesis in the hydrocortisone-treated rats. Dev Neurosci 1980;3:81-89.
52. Levine S, Huchton DM, Wiener SG et al. Time course of the effect of maternal deprivation on the hypothalamic-pituitary-adrenal axis in the infant rat. Dev Psychobiol 1991;24:547-558.
53. Suchecki D, Rosenfeld P, Levine S. Maternal regulation of the hypothalamic-pituitary-adrenal axis in the infant rat: the roles of feeding and stroking. Brain Res Dev Brain Res 1993;75:185-192.
54. van Oers HJ, de Kloet ER, Whelan T et al. Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone. J Neurosci 1998;18:10171-10179.
55. Debassio W, Kemper TL, Galler JR et al. Prenatal malnutrition effect on pyramidal and granule cell generation in the hippocampal formation. Brain Res Bull 1994;35:57-61.
56. Lister JP, Blatt GJ, DeBassio WA et al. Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation. Hippocampus 2005;15:393-403.
57. do Espirito Santo J, Portuguez, MW, Nunes, ML. Cognitive and behavioral status of low birth weight preterm children raised in a developing country at preschool age. J Pediatr (Rio J) 2009;85:35-41.
58. Hall A, Khanh LN, Son TH et al. An association between chronic undernutrition and educational test scores in Vietnamese children. Eur J Clin Nutr 2001;55:801-804.
59. Weiss IC, Feldon J. Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review. Psychopharmacology (Berl) 2001;156:305-326.
60. Susser E, Neugebauer R, Hoek HW et al. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry 1996;53:25-31.
61. Rioux L, Nissanov J, Lauber K et al. Distribution of microtubuleassociated protein MAP2-immunoreactive interstitial neurons in the parahippocampal white matter in subjects with schizophrenia. Am J Psychiatry 2003;160:149-155.
62. Lodygensky GA, Seghier ML, Warfield SK, et al. Intrauterine growth restriction affects the preterm infant's hippocampus. Pediatr Res 2008;63(4):438-43
63. Del Angel-Meza AR, Ramirez-Cortes L, Olvera-Cortes E et al. A tryptophan-deficient corn-based diet induces plastic responses in cerebellar cortex cells of rat offspring. Int J Dev Neurosci 2001;19:447-453.
64. Jahnke S, Bedi KS. Undernutrition during early life increases the level of apoptosis in the dentate gyrus but not in the CA2+CA3 region of the hippocampal formation. Brain Res 2007;1143:60-69.
65. Schlessinger AR, Cowan WM, Swanson LW. The time of origin of neurons in Ammon's horn and the associated retrohippocampal fields. Anat Embryol (Berl) 1978;154:153-173.
66. Bonthius DJ, West JR. Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure. Alcohol Clin Exp Res 1990;14:107-118.
67. Bonthius DJ, West JR. Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt. Teratology 1991;44:147-163.
68. West JR. Fetal alcohol-induced brain damage and the problem of determining temporal vulnerability: a review. Alcohol Drug Res 1987;7:423-441.