Environmental animal models for sensorimotor gating deficiencies in schizophrenia: A review

Psychopharmacology

Volumn 156, Issue 2-3, 2001, Pages 305-326

  Weiss, Isabelle C ^a   Feldon, Joram ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Animal models; Early handling; Maternal separation; Prepulse inhibition; Rat; Schizophrenia; Social isolation

Indexed keywords

NEUROLEPTIC AGENT;

ANIMAL MODEL; ENVIRONMENTAL FACTOR; MOTOR DYSFUNCTION; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; REVIEW; SCHIZOPHRENIA; SENSORY DYSFUNCTION; SOCIAL ENVIRONMENT; SOCIAL ISOLATION; STARTLE REFLEX;

ANIMALS; ENVIRONMENT; HANDLING (PSYCHOLOGY); MATERNAL DEPRIVATION; MODELS, PSYCHOLOGICAL; RATS; SCHIZOPHRENIC PSYCHOLOGY; STARTLE REACTION;

EID: 0034917848     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100800     Document Type: Review

References (210)

1. Repeated testing of prepulse inhibition and habituation of the startle reflex: A study in healthy human controls
2. 2 receptors by dopamine in schizophrenia
3. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia
4. Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization
5. Do early-life events permanently alter behavioral and hormonal responses to stressors?
6. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia
7. The neuropathology of schizophrenia
8. Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the non-competitive NMDA antagonist dizocilpine
9. Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats
10. Reversal of isolation rearing-induced deficits in prepulse inhibition by seroquel and olanzapine
11. Anatomic basis of cognitive-emotional interactions in the primate prefrontal cortex
12. Effects of MK801 and neuroleptics on prepulse inhibition: Re-examination in two strains of rats
13. Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine
14. Sex and strain differences of acoustic startle reaction development in adolescent albino Wistar and hooded rats
15. Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia
16. Prestimulus effects on human startle reflex in normals and schizophrenics
17. Gating and habituation of the startle reflex in schizophrenic patients
18. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients
19. The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat
20. Dissociative effects of apomorphine infusions into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine-induced locomotion
21. Conditioned fear as revealed by magnitude of startle response to an auditory stimulus
22. Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex
23. Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder
24. Effects of early handling on amphetamine-induced locomotor activation and conditioned place preference in the adult rat
25. Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results
26. Differences in distribution of ages of onset in males and females with schizophrenia
27. Differential rearing alters spine density on medium-sized spiny neurons in the rat corpus striatum: Evidence for association of morphological plasticity with early response gene expression
28. Isolation rearing of rats alters release of 5-hydroxytryptamine and dopamine in the frontal cortex: An in vivo electrochemical study
29. Behavioural inhibition and the age at social isolation in rats
30. Pharmacological and anatomical analysis of fear conditioning using the fear potentiated startle paradigm
31. Sensitization of the acoustic startle reflex by footshock
32. A primary acoustic startle circuit: Lesion and stimulation studies
33. Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in the rat
34. Fear-potentiated startle: A neural and pharmacological analysis
35. The effects of smoking on acoustic prepulse inhibition in healthy men and women
36. Potentiation of prepulse inhibition of the startle reflex in rats: Pharmacological evaluation of the procedure as a model for detecting antipsychotic activity
37. Some, but not all, antipsychotic drugs potentiate a low level of prepulse inhibition shown by rats of the Wistar strain
38. Tactile-visual acquisition and reversal learning deficits in rats with prefrontal cortical lesions
39. The disruption of prepulse inhibition by social isolation in the Wistar rat: How robust is the effect?
40. Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography
41. Neurobiology of schizophrenia
42. A critical period for social isolation in the rat
43. Maternal separation reduces latent inhibition in the conditioned taste aversion paradigm
44. The long-term effects of maternal deprivation depend on the genetic background
45. Prepulse inhibition and latent inhibition: The role of dopamine in the medial prefrontal cortex
46. The effects of an early stressful life event on sensorimotor gating in adult rats
47. Effects of nicotine and stress on startle amplitude and sensory gating depend on rat strain and sex
48. The effects of subchronic haloperidol on intact and dizocilpine-disrupted sensorimotor gating
49. Long-term attentional deficit in nonhandled males: Possible involvement of the dopaminergic system
50. The effects of pre- and postweaning rearing conditions on latent inhibition and partial reinforcement extinction effect in male rats
51. Rat latent inhibition and prepulse inhibition are sensitive to different manipulations of the social environment: A comprehensive study of the environmental approach to neurodevelopmental models of schizophrenia
52. Developmental stress disrupts habituation but spares prepulse inhibition in young rats
53. Estrogen control of central neurotransmission: Effect on mood, mental state, and memory
54. Circadian modulation in the rat acoustic startle circuit
55. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: Comparison of medicated and drug-free patients
56. The left medial temporal region and schizophrenia. A PET study
57. Stereotyped responding by schizophrenic patients on a two-choice guessing task
58. Effect of isolation-rearing on conditioned dopamine release in vivo in the nucleus accumbens of the rat
59. Stress adaptation and adrenal activity in isolated and crowded rats
60. Environmental enrichment and deprivation: Effects on learning, memory and exploration
61. Locomotor activity, defecation score and corticosterone levels during an openfield exposure: A comparison among individually and group-housed rats, and genetically selected rat lines
62. Different reaction patterns in individually and socially reared rats during exposures to novel environments
63. Isolation-induced locomotor hyperactivity and hypoalgesia in rats are prevented by handling and reversed by resocialization
64. Startle habituation and sensorimotor gating in schizophrenia and related animal models
65. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia
66. Individual housing does not influence the adaptation of the pituitary-adrenal axis and other physiological variables to chronic stress in adult male rats
67. Acquisition and extinction of an operant response in differentially reared rats
68. The more or less startling effects of weak pre-stimulation
69. Effects of isolation, daily handling, and enriched rearing on maze learning
70. Startle gating deficits occur across prepulse intensities in schizophrenic patients
71. Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences
72. Effects of isolation-rearing on acoustic startle and pre-pulse inhibition in Wistar and Fawn Hooded rats
73. The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty
74. Social deprivation in monkeys
75. Isolation syndrome in the rat
76. Perseveration, inhibition and the prefrontal cortex: A new look
77. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
78. Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome
79. The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801
80. Reflex modulation in the domain of startle: I Some empirical findings and their implications for how the nervous system processes sensory input
81. Feeding neophobia: A possible explanation for the differential maze performance of rats reared in enriched or isolated environments
82. Adrenocortical, beta-endorphin and behavioral responses to graded stressors in differentially reared rats
83. "Isolation stress" revisited: Isolation-rearing effects depend on animal care methods
84. Elevation of striatal dopamine receptors by estrogen: Dose and time studies
85. Effect of d-amphetamine on prepulse inhibition of the startle reflex in humans
86. Behavioural rigidity and rule-learning deficits following isolation-rearing in the rat: Neurochemical correlates
87. Dopaminergic and serotonergic function following isolation rearing in rats: Study of behavioural responses and postmortem and in vivo neurochemistry
88. Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle
89. Rat strain differences in the ability to disrupt sensorimotor gating are limited to the dopaminergic system, specific to prepulse inhibition, and unrelated to changes in startle amplitude or nucleus accumbens dopamine receptor sensitivity
90. Induction of Fos-protein in the forebrain and disruption of sensorimotor gating following N-methyl-D-aspartate infusion into the ventral hippocampus of the rat
91. Dopamine, the prefrontal cortex and schizophrenia
92. Sensorimotor gating changes across the estrous cycle in female rats
93. The neurobiology of startle
94. Deficient sensorimotor gating after 6-hydroxydopamine lesion of the rat medial prefrontal cortex is reversed by haloperidol
95. The acoustic startle response in rats - Circuits mediating evocation, inhibition and potentiation
96. Lesions of the rat piriform cortex prevent long-lasting sensorimotor gating deficits induced by stimulation of the ventral hippocampus
97. 2 receptors in instrumental and Pavlovian paradigms of conditioned reward
98. Quinolinic acid lesions of the ventral striatum reduce sensorimotor gating of acoustic startle in rats
99. Normalization of information processing deficits in schizophrenia with clozapine
100. The effects of excitotoxic lesion of the medial prefrontal cortex on latent inhibition, prepulse inhibition, food hoarding, elevated plus maze, active avoidance and locomotor activity in the rat
101. Effects of local infusions of dopaminergic drugs into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine induced activity
102. Differential role of the medial and lateral prefrontal cortices in fear and anxiety
103. Emotion, attention, and the startle reflex
104. Long-term biobehavioral effects of maternal separation in the rat: Consistent or confusing?
105. Long-term effects of repeated maternal separation on three different latent inhibition paradigms
106. The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats
107. Sex differences in the acoustic startle response and prepulse inhibition in Wistar rats
108. Lack of effect of an early stressful life event on sensorimotor gating in adult rats
109. Long-term effects of prenatal stress experiences and postnatal maternal separation on emotionality and attentional processes
110. The neural substrate of the startle response
111. Maternal and environmental influences on the adrenocortical response to stress in weanling rats
112. The ontogeny of the hypothalamic-pituitary-adrenal axis. The influence of maternal factors
113. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia
114. Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine
115. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
116. Shuttle-box-avoidance performance and basal corticosterone levels as a function of duration of individual housing in rats
117. Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat
118. Dopaminergic stimulation disrupts sensorimotor gating in the rat
119. 4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition
120. Temporal integration in the acoustic startle reflex of the rat
121. Ontogeny of phencyclidine and apomorphine-induced startle gating deficits in rats
122. Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: Effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine
123. Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: Gender-dependent effects
124. Effect of neonatal handling on age-related impairments associated with the hippocampus
125. Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat
126. Post-natal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats
127. Environmental regulation of the development of glucocorticoid receptor systems in the rat forebrain. The role of serotonin
128. Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress
129. Adult schizophrenia following prenatal exposure to an influenza epidemic
130. The dopamine hypothesis of schizophrenia: A review
131. Long-term isolation of Wistar rats alters brain monoamine turnover, blood corticosterone, and ACTH
132. Incentive motivation and behavioral inhibition in socially-isolated rats
133. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats
134. Extinction of emotional learning: Contribution of medial prefrontal cortex
135. The effects of isolation rearing on behavioural inhibition in the rat
136. Inhibition and isolation rearing in the rat: Extinction and satiation
137. Some anatomical and physiological correlates of social isolation in the young rat
138. Lower incidence and increased male:female ratio in schizophrenia
139. Involvement of the pituitary-adrenal axis in socio-behavioral disturbances after short-term isolation
140. Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic
141. Obstetric complications and schizophrenia: A computed tomographic study
142. Impaired prepulse inhibition of acoustic startle in schizophrenia
143. Information-processing deficits and thought disorder in schizophrenia
144. Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients
145. Pre-weaning non-handling of rats disrupts latent inhibition in males, and results in persisting sex- and area-dependent increases in dopamine and serotonin turnover
146. Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor
147. Isolation-rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine
148. The effects of hippocampal and fimbria-fornix lesions on prepulse inhibition
149. Comparison of the effects of infant handling, isolation, and non-handling on acoustic startle, prepulse inhibition, locomotion, and HPA activity in the adult rat
150. Search for schizophrenia susceptibility genes
151. Handling and isolation in three strains of rats affect open field, exploration, hoarding and predation
152. Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains
153. Prepulse inhibition as a screening test for potential antipsychotics
154. Neonatal maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine
155. The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats
156. Effects of prolonged social isolation on responses of neurons in the bed nucleus of the stria terminalis, preoptic area, and hypothalamic paraventricular nucleus to stimulation of the medial amygdala
157. Psychopathology in women and men: Focus on female hormones
158. Bimodal distribution of dopamine receptor densities in brains of schizophrenics
159. X-Ray computerized tomography studies of schizophrenia: A review and synthesis
160. Postweaning housing effects on nitric oxide-(NO) producing neurons of the prefrontal cortex in rats. ENA Meeting, Berlin
161. Abnormalities of the blink reflex in Gilles de la Tourette syndrome
162. The dopamine hypothesis of schizophrenia: Focus on the dopamine receptor
163. Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats
164. Behavioural and hormonal differences between two Lewis rat lines
165. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia
166. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia
167. Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine
168. The neural substrates of sensorimotor gating of the startle reflex: A review of recent findings and their implications
169. Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats
170. Men are more inhibited than women by weak prepulses
171. A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder
172. Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients
173. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats
174. Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease
175. Changes in sensorimotor inhibition across the menstrual cycle: Implications for neuropsychiatric disorders
176. Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats
177. Sex differences in sensorimotor gating of the human startle reflex: All smoke?
178. Animal models of deficient sensorimotor gating: What we know, what we think we know, and what we hope to know soon
179. Toward understanding the biology of a complex phenotype: Rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists
180. Relationship between in utero exposure to influenza epidemics and risk of schizophrenia in Denmark
181. Full recovery from schizophrenia: The prognostic role of premorbid adjustment, symptoms at first admission, precipitating events and gender
182. Recent advances in genetic research on schizophrenia
183. Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: Correlation with stress-induced corticosterone secretion
184. Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats
185. Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: Influence of apomorphine and phencyclidine pretreatment
186. Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs
187. Is there a critical developmental "window" for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response?
188. Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats
189. Environmental enrichment and isolation rearing in the rat: Effects on locomotor behavior and startle response plasticity
190. 2A-agonists on prepulse inhibition in human volunteers
191. Effects of individual housing and stressor exposure upon the acquisition of watermaze escape
192. The basolateral amygdala regulates sensorimotor gating of acoustic startle in the rat
193. Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients
194. Early handling effects on neophobia and conditioned taste aversion
195. Implications of normal brain development for the pathogenesis of schizophrenia
196. The biological basis of schizophrenia: New directions
197. The effects of early handling on latent inhibition in male and female rats
198. Early handling and latent inhibition in the conditioned suppression paradigm
199. Isolation rearing-induced disruption of prepulse inhibition: Further evidence for fragility of the response
200. Strain differences in the isolation-induced effects on prepulse inhibition of the acoustic startle response and on locomotor activity
201. Dissociation between the effects of pre-weaning and/or post-weaning social isolation on prepulse inhibition and latent inhibition in adult Sprague-Dawley rats
202. Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition
203. Isolation rearing prevents the reinforcing properties of amphetamine in a conditioned place preference paradigm
204. Effects of social isolation rearing on learning in the Morris water maze
205. Resocialisation of isolation-reared rats does not alter their anxiogenic profile on the elevated X-maze model of anxiety
206. Cytotoxic lesion of the medial prefrontal cortex abolishes the partial reinforcement extinction effect, attenuates prepulse inhibition of the acoustic startle reflex and induces transient hyperlocomotion, while sparing spontaneous object recognition memory in the rat
207. Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics
208. Temperature-dependent effects of maternal separation on growth, activity, and amphetamine sensitivity in the rat