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Volumn 28, Issue 30, 2010, Pages 4609-4615

Phase II study of dasatinib in patients with advanced non-small-cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; PROTEIN TYROSINE KINASE; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; RAS PROTEIN; THIAZOLE DERIVATIVE;

EID: 78049495513     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.30.5474     Document Type: Article
Times cited : (144)

References (40)
  • 2
    • 70349758510 scopus 로고    scopus 로고
    • Src kinases as therapeutic targets for cancer
    • Kim LC, Song L, Haura EB: Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6:587-595, 2009
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 587-595
    • Kim, L.C.1    Song, L.2    Haura, E.B.3
  • 3
    • 0037784223 scopus 로고    scopus 로고
    • pp60c-src activation in lung adenocarcinoma
    • Masaki T, Igarashi K, Tokuda M, et al: pp60c-src activation in lung adenocarcinoma. Eur J Cancer 39:1447-1455, 2003
    • (2003) Eur J Cancer , vol.39 , pp. 1447-1455
    • Masaki, T.1    Igarashi, K.2    Tokuda, M.3
  • 5
    • 26444468152 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells
    • DOI 10.1158/1078-0432.CCR-05-0757
    • Johnson FM, Saigal B, Talpaz M, et al: Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin Cancer Res 11:6924-6932, 2005 (Pubitemid 41428750)
    • (2005) Clinical Cancer Research , vol.11 , Issue.19 I , pp. 6924-6932
    • Johnson, F.M.1    Saigal, B.2    Talpaz, M.3    Donato, N.J.4
  • 6
    • 67649396221 scopus 로고    scopus 로고
    • The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells
    • Purnell PR, Mack PC, Tepper CG, et al: The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. J Thorac Oncol 4:448-454, 2009
    • (2009) J Thorac Oncol , vol.4 , pp. 448-454
    • Purnell, P.R.1    Mack, P.C.2    Tepper, C.G.3
  • 7
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • DOI 10.1158/0008-5472.CAN-05-4620
    • Song L, Morris M, Bagui T, et al: Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 66:5542-5548, 2006 (Pubitemid 43927102)
    • (2006) Cancer Research , vol.66 , Issue.11 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 8
    • 38949107292 scopus 로고    scopus 로고
    • EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: Implications in targeting therapy
    • DOI 10.1038/sj.onc.1210684, PII 1210684
    • Fu YN, Yeh CL, Cheng HH, et al: EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: Implications in targeting therapy. Oncogene 27:957-965, 2008 (Pubitemid 351225379)
    • (2008) Oncogene , vol.27 , Issue.7 , pp. 957-965
    • Fu, Y.-N.1    Yeh, C.-L.2    Cheng, H.H.-Y.3    Yang, C.-H.4    Tsai, S.-F.5    Huang, S.-F.6    Chen, Y.-R.7
  • 9
    • 67349269541 scopus 로고    scopus 로고
    • The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancerassociated EGF receptor mutants
    • Chung BM, Dimri M, George M, et al: The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancerassociated EGF receptor mutants. Oncogene 28: 1821-1832, 2009
    • (2009) Oncogene , vol.28 , pp. 1821-1832
    • Chung, B.M.1    Dimri, M.2    George, M.3
  • 10
    • 67649600824 scopus 로고    scopus 로고
    • SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy
    • Leung EL, Tam IY, Tin VP, et al: SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy. Mol Cancer Res 7:923-932, 2009
    • (2009) Mol Cancer Res , vol.7 , pp. 923-932
    • Leung, E.L.1    Tam, I.Y.2    Tin, V.P.3
  • 11
    • 23044472971 scopus 로고    scopus 로고
    • CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation
    • DOI 10.1158/0008-5472.CAN-04-1303
    • Cabioglu N, Summy J, Miller C, et al: CXCL- 12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res 65:6493-6497, 2005 (Pubitemid 41060680)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6493-6497
    • Cabioglu, N.1    Summy, J.2    Miller, C.3    Parikh, N.U.4    Sahin, A.A.5    Tuzlali, S.6    Pumiglia, K.7    Gallick, G.E.8    Price, J.E.9
  • 12
    • 0035884402 scopus 로고    scopus 로고
    • Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma
    • Pal S, Datta K, Mukhopadhyay D: Central role of p53 on regulation of vascular permeability factor/ vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res 61:6952-6957, 2001 (Pubitemid 32896524)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6952-6957
    • Pal, S.1    Datta, K.2    Mukhopadhyay, D.3
  • 15
    • 77949369418 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors
    • Johnson FM, Agrawal S, Burris H, et al: Phase I pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors. Cancer 116:1582-1591, 2009
    • (2009) Cancer , vol.116 , pp. 1582-1591
    • Johnson, F.M.1    Agrawal, S.2    Burris, H.3
  • 17
    • 77649310705 scopus 로고    scopus 로고
    • A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602)
    • Miller AA, Pang H, Hodgson L, et al: A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602). J Thorac Oncol 5:380-384, 2010
    • (2010) J Thorac Oncol , vol.5 , pp. 380-384
    • Miller, A.A.1    Pang, H.2    Hodgson, L.3
  • 18
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205-216, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 19
    • 66149139452 scopus 로고    scopus 로고
    • From RECIST to PERCIST: Evolving considerations for PET response criteria in solid tumors
    • suppl 1
    • Wahl RL, Jacene H, Kasamon Y, et al: From RECIST to PERCIST: Evolving considerations for PET response criteria in solid tumors. J Nucl Med 50:122S-150S, 2009 (suppl 1)
    • (2009) J Nucl Med , vol.50
    • Wahl, R.L.1    Jacene, H.2    Kasamon, Y.3
  • 20
    • 70349673597 scopus 로고    scopus 로고
    • Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors
    • Demetri GD, Lo Russo P, MacPherson IR, et al: Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res 15:6232-6240, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 6232-6240
    • Demetri, G.D.1    Lo Russo, P.2    MacPherson, I.R.3
  • 21
    • 77950491674 scopus 로고    scopus 로고
    • Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer
    • Haura EB, Tanvetyanon T, Chiappori A, et al: Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer. J Clin Oncol 28:1387-1394, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 1387-1394
    • Haura, E.B.1    Tanvetyanon, T.2    Chiappori, A.3
  • 24
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947-957, 2009
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 25
    • 62449283132 scopus 로고    scopus 로고
    • Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding
    • Sen B, Saigal B, Parikh N, et al: Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. Cancer Res 69:1958-1965, 2009
    • (2009) Cancer Res , vol.69 , pp. 1958-1965
    • Sen, B.1    Saigal, B.2    Parikh, N.3
  • 26
    • 77949848665 scopus 로고    scopus 로고
    • A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
    • Li J, Rix U, Fang B, et al: A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol 6:291-299, 2010
    • (2010) Nat Chem Biol , vol.6 , pp. 291-299
    • Li, J.1    Rix, U.2    Fang, B.3
  • 27
    • 67651006061 scopus 로고    scopus 로고
    • Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions
    • Sos ML, Michel K, Zander T, et al: Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest 119:1727-1740, 2009
    • (2009) J Clin Invest , vol.119 , pp. 1727-1740
    • Sos, M.L.1    Michel, K.2    Zander, T.3
  • 28
    • 65949104526 scopus 로고    scopus 로고
    • Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors
    • McDermott U, Ames RY, Iafrate AJ, et al: Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors. Cancer Res 69:3937-3946, 2009
    • (2009) Cancer Res , vol.69 , pp. 3937-3946
    • McDermott, U.1    Ames, R.Y.2    Iafrate, A.J.3
  • 29
    • 34248204234 scopus 로고    scopus 로고
    • Uncommon tumors and exceptional therapies: Paradox or paradigm?
    • Braiteh F, Kurzrock R: Uncommon tumors and exceptional therapies: Paradox or paradigm? Mol Cancer Ther 6:1175-1179, 2007
    • (2007) Mol Cancer Ther , vol.6 , pp. 1175-1179
    • Braiteh, F.1    Kurzrock, R.2
  • 30
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • DOI 10.1200/JCO.2006.06.2984
    • Curtin JA, Busam K, Pinkel D, et al: Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24:4340-4346, 2006 (Pubitemid 46630793)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 33
    • 68049088934 scopus 로고    scopus 로고
    • EGFR/KRAS/ BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
    • Schmid K, Oehl N, Wrba F, et al: EGFR/KRAS/ BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin Cancer Res 15:4554-4560, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 4554-4560
    • Schmid, K.1    Oehl, N.2    Wrba, F.3
  • 37
    • 65949102791 scopus 로고    scopus 로고
    • Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress
    • Kopetz S, Lesslie DP, Dallas NA, et al: Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. Cancer Res 69:3842-3849, 2009
    • (2009) Cancer Res , vol.69 , pp. 3842-3849
    • Kopetz, S.1    Lesslie, D.P.2    Dallas, N.A.3
  • 38
    • 70949093847 scopus 로고    scopus 로고
    • Effects of Src kinase inhibition induced by dasatinib in non-mall cell lung cancer cell lines treated with cisplatin
    • Ceppi P, Papotti M, Monica V, et al: Effects of Src kinase inhibition induced by dasatinib in non-mall cell lung cancer cell lines treated with cisplatin. Mol Cancer Ther 8:3066-3074, 2009
    • (2009) Mol Cancer Ther , vol.8 , pp. 3066-3074
    • Ceppi, P.1    Papotti, M.2    Monica, V.3
  • 39
    • 79951887897 scopus 로고    scopus 로고
    • Mechanisms of enhanced radiosensitivity of human head and neck squamous cell carcinomas by dasatinib (BMS-354825, an inhibitor of Src kinases) include induction of apoptosis and inhibition of DNA repair
    • Raju U, Johnson FM, Glisson BS, et al: Mechanisms of enhanced radiosensitivity of human head and neck squamous cell carcinomas by dasatinib (BMS-354825, an inhibitor of Src kinases) include induction of apoptosis and inhibition of DNA repair, Proceedings of the American Association for Cancer Research, San Diego, CA, 2008, pp 642
    • Proceedings of the American Association for Cancer Research, San Diego, CA, 2008 , pp. 642
    • Raju, U.1    Johnson, F.M.2    Glisson, B.S.3
  • 40
    • 66149083997 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab
    • Wheeler DL, Iida M, Kruser TJ, et al: Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab. Cancer Biol Ther 8:696-703, 2009
    • (2009) Cancer Biol Ther , vol.8 , pp. 696-703
    • Wheeler, D.L.1    Iida, M.2    Kruser, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.