Quantitative, architectural analysis of immune cell subsets in tumor-draining lymph nodes from breast cancer patients and healthy lymph nodes

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Setiadi, A Francesca ^a   Ray, Nelson C ^b   Kohrt, Holbrook E ^a   Kapelner, Adam ^a   Carcamo Cavazos, Valeria ^a   Levic, Edina B ^a   Yadegarynia, Sina ^a   van der Loos, Chris M ^c   Schwartz, Erich J ^a   Holmes, Susan ^b   Lee, Peter P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD LAW SCHOOL   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; B LYMPHOCYTE; BREAST CANCER; CANCER CELL; CELL DENSITY; CELL INTERACTION; CELL POPULATION; CELL STRUCTURE; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE QUALITY; IMMUNOCOMPETENT CELL; LYMPH NODE; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; TISSUE SECTION;

EID: 78049493470     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012420     Document Type: Article

References (15)

1. Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, et al. (2010) Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 29: 1093-1102.
2. Quan ML, McCready D (2009) The evolution of lymph node assessment in breast cancer. J Surg Oncol 99: 194-198.
3. Domenech A, Benitez A, Bajen MT, Ricart Y, Rodriguez-Gasen A, et al. (2009) What are the preoperative factors that can determine the presence of metastases in other axillary nodes in breast cancer when the sentinel node is positive? Q J Nucl Med Mol Imaging 53: 422-427.
4. Kohrt HE, Nouri N, Nowels K, Johnson D, Holmes S, et al. (2005) Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer. PLoS Med 2: e284.
5. Holmes S, Kapelner A, Lee PP (2009) An interactive java statistical image segmentation system: GemIdent. J Stat Soft 30.
6. Dixon PM (2002) Ripley's K function. In: El-Shaarawi AH, Piegorsch WW, eds. Encyclopedia of Environmetrics. Chichester: John Wiley & Sons, Ltd. pp 1796-1803.
7. Besag J, Diggle PJ (1977) Simple Monte Carlo tests for spatial pattern. Appl Statist 26: 327-333.
8. Parzen E (1962) On estimation of a probability density function and mode. Ann Math Stat 22: 1065-1076.
9. van der Loos CM (2008) Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging. J Histochem Cytochem 56: 313-328.
10. Janeway C, Travers P, Walport M, Shlomchik M (2001) Immunobiology: the immune system in health and disease. New York, NY Garland Publishing.
11. Qi H, Egen JG, Huang AY, Germain RN (2006) Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312: 1672-1676.
12. Diggle PJ (2003) Statistical analysis of spatial point patterns. New York: Academic Press.
13. Bivand R (2001) More on spatial data analysis. R News 1: 13-17.
14. Baddeley A, Turner R (2005) Spatstat: an R package for analyzing spatial point patterns. J Stat Soft 12: 1-42.
15. Silverman BW (1986) Density estimation for statistics and data analysis. London: Chapman and Hall.