Successful 'passive transfer' of paraneoplastic stiff person syndrome with antibodies to an intracellular antigen

Brain

Volumn 133, Issue 11, 2010, Pages 3164-3165

  Vincent, Angela ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMPHIPHYSIN; AMPHIPHYSIN ANTIBODY; CELL ANTIGEN; GLUTAMIC ACID; IMMUNOGLOBULIN G; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; HUMAN; IMMUNOFLUORESCENCE; MUSCLE SPASM; MUSCLE STIFFNESS; NEUROPHYSIOLOGICAL RECRUITMENT; NEUROTRANSMITTER RELEASE; NOTE; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; STIFF MAN SYNDROME; SYNAPSE VESICLE;

AUTOANTIBODIES; AUTOANTIGENS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; IMMUNIZATION, PASSIVE; INJECTIONS, SPINAL; INTRACELLULAR FLUID; NERVE TISSUE PROTEINS; STIFF-PERSON SYNDROME;

EID: 78049485274     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq302     Document Type: Note

References (15)

1. Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromye-litis optica. Ann Neurol 2009; 66: 617-29.
2. Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, et al. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009; 66: 630-43.
3. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7: 1091-8.
4. Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. J Neurol 2010; 257: 509-17.
5. Geis C, Weishaupt A, Hallermann S, Grü newald B, Wessig C, Wultsch T, et al. Stiff person syndrome associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 2010; 133: 3162-76.
6. Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010; 133: 2734-48.
7. Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, et al. Neuromyelitis optica: passive transfer to rats by human immunoglobu-lin. Biochem Biophys Res Commun 2009; 386: 623-7.
8. Lai M, Huijbers MG, Lancaster E, Graus F, Bataller L, Balice-Gordon R, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: A case series. Lancet Neurol 2010; 9: 776-85.
9. Lang B, Newsom-Davis J, Prior C, Wray D. Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouse. J Physiol 1983; 344: 335-45.
10. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005; 202: 473-7.
11. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Intra-cerebral injection of neuromyelitis optica im-munoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain 2010; 133: 349-61.
12. Solimena M, Folli F, Denis-Donini S, Comi GC, Pozza G, De Camilli P, et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. N Engl J Med 1988; 318: 1012-20.
13. Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, Gold R, et al. Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet 2005; 365: 1406-11.
14. Toyka KV, Drachman DB, Pestronk A, Kao I. Myasthenia gravis: passive transfer from man to mouse. Science 1975; 190: 397-9.
15. Wu Y, Matsui H, Tomizawa K. Amphiphysin I and regulation of synaptic vesicle endocytosis. Acta Med Okayama 2009; 63: 305-23.