Men with mild erectile dysfunction benefit from sildenafil treatment

Journal of Sexual Medicine

Volumn 7, Issue 11, 2010, Pages 3725-3735

  Bénard, Francois ^a   Carrier, Serge ^b   Lee, Jay C ^c   Talwar, Varun ^d   Defoy, Isabelle ^e  

^a UNIVERSITY OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Rockyview Hospital   (Canada)

^d Sciformix Technologies Pvt Ltd   (India)

^e PFIZER INC   (United States)

Author keywords

Erectile Dysfunction; Patient Satisfaction; Sildenafil; Treatment Outcome

Indexed keywords

PLACEBO; SILDENAFIL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DYSPEPSIA; ERECTILE DYSFUNCTION; FLUSHING; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HYPESTHESIA; MAJOR CLINICAL STUDY; MALE; MIGRAINE; MULTICENTER STUDY; NOSE CONGESTION; OUTCOME ASSESSMENT; PATIENT SATISFACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEXUAL BEHAVIOR; SIDE EFFECT; TREATMENT RESPONSE;

EID: 78049478942     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.02015.x     Document Type: Article

References (37)

1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
2. Koskimaki J, Hakama M, Huhtala H, Tammela TL. Effect of erectile dysfunction on frequency of intercourse: A population based prevalence study in Finland. J Urol 2000;164:367-70.
3. Grover SA, Lowensteyn I, Kaouache M, Marchand S, Coupal L, DeCarolis E, Zoccoli J, Defoy I. The prevalence of erectile dysfunction in the primay care setting; Importance of risk factors for diabetes and vascular disease. Arch Intern Med 2006;166:213-9.
4. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999;54:346-51.
5. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822-30.
6. Fisher WA, Rosen RC, Eardley I, Niederberger C, Nadel A, Kaufman J, Sand M. The multinational Men's Attitudes to Life Events and Sexuality (MALES) Study Phase II: Understanding PDE5 inhibitor treatment seeking patterns, among men with erectile dysfunction. J Sex Med 2004;1:150-60.
7. Torrance GW, Keresteci MA, Casey RW, Rosner AJ, Ryan N, Breton MC. Development and initial validation of a new preference-based disease-specific health-related quality of life instrument for erectile function. Qual Life Res 2004;13:349-59.
8. Donatucci C, Taylor T, Thibonnier M, Bangerter K, Gittelman M, Casey R. Vardenafil improves patient satisfaction with erection hardness, orgasmic function, and overall sexual experience, while improving quality of life in men with erectile dysfunction. J Sex Med 2004;1:185-92.
9. Fisher WA, Rosen RC, Mollen M, Brock G, Karlin G, Pommerville P, Goldstein I, Bangerter K, Bandel TJ, Derogatis LR, Sand M. Improving the sexual quality of life of couples affected by erectile dysfunction: A double-blind, randomized, placebo-controlled trial of vardenafil. J Sex Med 2005;2:699-708.
10. Giuliano F, Peña BM, Mishra A, Smith MD. Efficacy results and quality-of-life measures in men receiving sildenafil citrate for the treatment of erectile dysfunction. Qual Life Res 2001;10:359-69.
11. Glina S, Damiao R, Abdo C, Afif-Abdo J, Tseng LJ, Stecher V. Self-esteem, confidence, and relationships in Brazilian men with erectile dysfunction receiving sildenafil citrate: A randomized, parallel-group, double-blind, placebo-controlled study in Brazil. J Sex Med 2009;6:268-75.
12. Jones LA, Klimberg IW, McMurray JG, Padula R, Tseng L-J, Stecher VJ, multicenter study group. Effect of sildenafil citrate on the male sexual experience assessed with the Sexual Experience Questionnaire; a multicenter, double-blind, placebo-controlled trial with open-label extension. J Sex Med 2008;5:1955-64.
13. Kadioglu A, Grohmann W, Depko A, Levinson I, Sun F. Collins S, for the Multicenter Study Group. Quality of erections in men treated with flexible-dose sildenafil for erectile dysfunction: Multicenter trial with a double-blind, randomized, placebo-controlled phase and an open-label phase. J Sex Med 2008;5:726-34.
14. Kaminetsky JC, Depko AJ, Stroberg P, Buvat J, Tseng LJ, Stecher VJ. In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being. J Sex Med 2009;6:800-8.
15. Loran OB, Stroberg P, Lee SW, Park NC, Kim SW, Tseng LJ, Collins S, Stecher VJ. Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: Effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. J Sex Med 2009;6:2826-35.
16. Martin-Morales A, Meijide F, Garcia N, Artes M, Munoz A. Efficacy of vardenafil and influence on self-esteem and self-confidence in patients with severe erectile dysfunction. J Sex Med 2007;4:440-7.
17. Moncada I, Martinez-Jabaloyas JM, Rodriguez-Vela L, Gutierrez PR, Giuliano F, Koskimaki J, Farmer IS, Renedo VP, Schnetzler G. Emotional changes in men treated with sildenafil citrate for erectile dysfunction: A double-blind, placebo-controlled clinical trial. J Sex Med 2009;6:3469-77.
18. Rosen R, Goldstein I, Huang XY, Bangerter K, Taylor T. The Treatment Satisfaction Scale (TSS) is a sensitive measure of treatment effectiveness for both patients and partners: Results of a randomized controlled trial with vardenafil. J Sex Med 2007;4:1009-21.
19. Rubio-Aurioles E, Kim ED, Rosen RC, Porst H, Burns P, Zeigler H, Wong DG. Impact on erectile function and sexual quality of life of couples: A double-blind, randomized, placebo-controlled trial of tadalafil taken once daily. J Sex Med 2009;6:1314-23.
20. Seftel AD, Buvat J, Althof SE, McMurray JG, Zeigler HL, Burns PR, Wong DG. Improvements in confidence, sexual relationship and satisfaction measures: Results of a randomized trial of tadalafil 5 mg taken once daily. Int J Impot Res 2009;21:240-8.
21. McCullough AR, Steidle CP, Kaufman J, Goldfischer ER, Klee B, Carlsson M. Sildenafil citrate efficacy 8 hours postdose in men with mild to moderate erectile dysfunction. Int J Impot Res 2008;20:388-95.
22. McCullough AR, Steidle CP, Klee B, Tseng LJ. Randomized, double-blind, crossover trial of sildenafil in men with mild to moderate erectile dysfunction: Efficacy at 8 and 12 hours postdose. Urology 2008;71:686-92.
23. Tolra JR, Campana JM, Ciutat LF, Miranda EF. Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors. J Sex Med 2006;3:901-9.
24. Sommer F, Klotz T, Engelmann U. Improved spontaneous erectile function in men with mild-to-moderate arteriogenic erectile dysfunction treated with a nightly dose of sildenafil for one year: A randomized trial. Asian J Androl 2007;9:134-41.
25. Nagao K, Kimoto Y, Marumo K, Tsujimura A, Vail GM, Watts S, Ishii N, Kamidono S. Efficacy and safety of tadalafil 5, 10, and 20 mg in Japanese men with erectile dysfunction: Results of a multicenter, randomized, double-blind, placebo-controlled study. Urology 2006;68:845-51.
26. Young JM, Feldman RA, Auerbach SM, Kaufman JM, Garcia CS, Shen W, Murphy AM, Beasley CM Jr, Hague JA, Ahuja S. Tadalafil improved erectile function at twenty-four and thirty-six hours after dosing in men with erectile dysfunction: US trial. J Androl 2005;26:310-8.
27. Althof SE, Corty EW, Levine SB, Levine F, Burnett AL, McVary K, Stecher V, Seftel AD. EDITS: Development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology 1999;53:793-9.
28. Porst H, Gilbert C, Collins S, Huang X, Symonds T, Stecher V, Hvidsten K. Development and validation of the quality of erection questionnaire. J Sex Med 2007;4:372-81.
29. Mulhall JP, Goldstein I, Bushmakin AG, Cappelleri JC, Hvidsten K. Validation of the Erection Hardness Score (EHS). J Sex Med 2007;4:1626-34.
30. McMurray JG, Feldman RA, Auerbach SM, DeRiesthal H, Wilson N. on behalf of the Multicenter Study Group.Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction. Ther Clin Risk Manag 2007;3:975-81.
31. Mulhall JP, Levine LA, Jünemann KP. Erection hardness, a unifying factor for defining response in the treatment of erectile dysfunction. Urology 2006;68:17-25.
32. Claes HIM, Goldstein I, Althof SE, Berner MM, Cappelleri JC, Bushmakin AG, Symonds T, Schnetzler G. Understanding the effects of sildenafil treatment on erection maintenance and erection hardness. J Sex Med 2010;7:2184-91.
33. Althof SE, Berner M, Goldstein I, Claes HIM, Cappelleri JC, Bushmakin AG, Symonds T, Schnetzler G. Interrelationships of sildenafil treatment effects on the physiological and psychosocial aspects of erectile dysfunction of mixed or organic etiology. J Sex Med 2010;7:3170-8.
34. Lewis R, Bennett CJ, Borkon WD, Boykin WH, Althof SE, Stecher VJ, Siegel RL. Patient and partner satisfaction with Viagra (sildenafil citrate) treatment as determined by the erectile dysfunction inventory of treatment satisfaction questionnaire. Urology 2001;57:960-5.
35. Cappelleri JC, Althof SE, Siegel RL, Shpilsky A, Bell SS, Duttagupta S. Development and validation of the Self-Esteem And Relationship (SEAR) questionnaire in erectile dysfunction. Int J Impot Res 2004;16:30-8.
36. Donatucci C, Eardley I, Buvat J, Gittelman M, Kell P, Segerson T, Homering M, Montorsi F. Vardenafil improves erectile function in men with erectile dysfunction irrespective of disease severity and disease classification. J Sex Med 2004;1:301-9.
37. Lammers PI, Rubio-Aurioles E, Castell R, Castaneda J, Ponce De Leon R, Hurley D, Lipezker M, Loehr LA, Lowrey F. Combination therapy for erectile dysfunction: A randomized, double blind, unblinded active-controlled, cross-over study of the pharmacodynamics and safety of combined oral formulations of apomorphine hydrochloride, phentolamine mesylate and papaverine hydrochloride in men with moderate to severe erectile dysfunction. Int J Impot Res 2002;14:54-9.