Understanding the effects of sildenafil treatment on erection maintenance and erection hardness

Journal of Sexual Medicine

Volumn 7, Issue 6, 2010, Pages 2184-2191

  Claes, Hubert I M ^a   Goldstein, Irwin ^b   Althof, Stanley E ^c   Berner, Michael M ^d   Cappelleri, Joseph C ^e   Bushmakin, Andrew G ^e   Symonds, Tara ^f   Schnetzler, Gabriel ^e  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b ALVARADO HOSPITAL   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

^e PFIZER INC   (United States)

^f PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

ED Treatment; Erection Harness; Erection Maintenance; Longitudinal Model; Mediation Model; Phosphodiesterase Type 5 Inhibitor; Sildenafil; Viagra

Indexed keywords

PLACEBO; SILDENAFIL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; EFFECT SIZE; ERECTILE DYSFUNCTION; HARDNESS; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; LONGITUDINAL STUDY; MALE; OPEN STUDY; PENIS ERECTION; PRIORITY JOURNAL; SCORING SYSTEM; SEXUAL SATISFACTION; STATISTICAL MODEL; TREATMENT DURATION;

EID: 77953930272     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.01791.x     Document Type: Article

References (28)

1. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993, 270:83-90. NIH Consensus Conference
2. Mulhall JP, Althof SE, Brock GB, Goldstein I, Jünemann K-P, Kirby M. Erectile dysfunction: Monitoring response to treatment in clinical practice-recommendations of an international consensus panel. J Sex Med 2007, 4:448-64.
3. Mulhall JP, Levine LA, Jünemann K-P. Erection hardness, a unifying factor for defining response in the treatment of erectile dysfunction. Urology 2006, 68:17-25.
4. Mulhall JP, Goldstein I, Bushmakin AG, Cappelleri JC, Hvidsten K. Validation of the erection hardness score (EHS). J Sex Med 2007, 4:1626-34.
5. Cappelleri JC, Bushmakin AG, Symonds T, Schnetzler G. Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4). J Sex Med 2009, 6:809-19.
6. Loran OB, Stroberg P, Lee SW, Park NC, Kim SW, Tseng LJ, Collins S, Stecher VJ. Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: Effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. J Sex Med 2009, 6:2826-35.
7. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997, 49:822-30.
8. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999, 54:346-51.
9. Rosen RC, Cappelleri JC, Gendrano N. The International Index of Erectile Function (IIEF): A state-of-the-science review. Int J Impot Res 2002, 14:226-44.
10. SAS/STAT® user's guide. Version 8.2 2001, SAS Institute Inc, Cary, NC, SAS Institute
11. Singer JD, Willett JB. Applied longitudinal data analysis: Modeling change and event occurrence 2003, New York, Oxford University Press
12. Cohen J. Statistical power analysis for the behavioral sciences 1988, 19-74. 2nd, edition, Hillsdale, NJ, Lawrence Erlbaum Associates
13. Iacobucci D. Mediation analysis 2008, Los Angeles, CA, Sage Publications
14. MacKinnon DP. Introduction to statistical mediation analysis 2008, New York, Taylor & Francis Group
15. Althof SE, Berner M, Goldstein I, Claes HIM, Cappelleri JC, Bushmakin AG, Symonds T, Schnetzler G. Interrelationships of sildenafil treatment effects on the physiological and psychosocial aspects of erectile dysfunction. J Sex Med 2009, in press
16. Claes H, Opsomer R-J, Andrianne RS, Vanbelle S, Albert A, Vanderdonck F. Characteristics and expectations of patients with erectile dysfunction: Results of the SCORED study. Int J Impot Res 2008, 20:418-24.
17. Claes H, van Hove J, van de Voorde W, Lauweryns J, de Roo E, Lysens R, Baert L. Pelvi-perineal rehabilitation for dysfunctioning erections. A clinical and anatomo-physiologic study. Int J Impot Res 1993, 5:13-26.
18. Gillon G, Barnea O. Erection mechanism of the penis: A model based analysis. J Urol 2002, 168:2711-5.
19. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M. A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005, 2:492-7.
20. Giuliano F, Patrick DL, Porst H, La Pera G, Kokoszka A, Merchant S, Rothman M, Gagnon DD, Polverejan E. Premature ejaculation: Results from a five-country European observational study. Eur Urol 2008, 53:1048-57.
21. Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, McNulty P, Rothman M, Jamieson C. Premature ejaculation: An observational study of men and their partners. J Sex Med 2005, 2:358-67.
22. Miner M, Gilderman L, Bailen J, Cook D, Dawson K, Stanislaus M, Beresford E, Barnes A. Vardenafil in men with stable statin therapy and dyslipidemia. J Sex Med 2008, 5:1455-67.
23. Rosenberg MT, Adams PL, McBride TA, Roberts JN, McCallum SW. Improvement in duration of erection following phosphodiesterase type 5 inhibitor therapy with vardenafil in men with erectile dysfunction: The ENDURANCE study. Int J Clin Pract 2009, 63:27-34.
24. Eardley I, Ellis P, Boolell M, Wulff M. Onset and duration of action of sildenafil citrate for the treatment of erectile dysfunction. Br J Clin Pharmacol 2002, 53:61S-5S.
25. Valiquette L, Montorsi F, Auerbach S. Vardenafil demonstrates first-dose success and reliability of penetration and maintenance of erection in men with erectile dysfunction-RELY-II. Can Urol Assoc J 2008, 2:187-95.
26. Kadioglu A, Grohmann W, Depko A, Levinson IP, Sun F, Collins S. Quality of erections in men treated with flexible-dose sildenafil for erectile dysfunction: Multicenter trial with a double-blind, randomized, placebo-controlled phase and an open-label phase. J Sex Med 2008, 5:726-34.
27. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998, 338:1397-404.
28. Lowy M, Collins S, Bloch MT, Gillman M, Lording DW, Sutherland P, Wang H, Stecher V. Quality of erection questionnaire correlates: Change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. J Sex Med 2007, 4:83-92.