A practical implementation and exploitation of ATPS for intensive processing of biological feedstock: A novel approach for heavily biological feedstock loaded ATPS

Separation and Purification Technology

Volumn 75, Issue 3, 2010, Pages 323-331

  Selvakumar, Pitchaivelu ^a,c   Ling, Tau Chuan ^a,b   Walker, Simon ^a   Lyddiatt, Andrew ^a,d  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c Avecia Biotechnology   (United Kingdom)

^d NEWCASTLE UNIVERSITY BUSINESS SCHOOL   (United Kingdom)

Author keywords

Aqueous two phase systems; Binodal; Biological feedstock; Distribution analysis of radiolabelled analytes; Tie line length

Indexed keywords

AQUEOUS TWO PHASE SYSTEM; BINODAL; BIOLOGICAL FEEDSTOCK; DISTRIBUTION ANALYSIS; TIE-LINE;

BLOOD; DEBRIS; PHASE DIAGRAMS;

FEEDSTOCKS;

BOVINAE;

EID: 78049448550     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2010.08.022     Document Type: Article

References (24)

1. T.M. Przybycien, N.S. Pujar, and L.M. Steele Alternative bioseparation operations: life beyond packed-bed chromatography Curr. Opin. Biotechnol. 15 2004 469 478
2. H.O. Johansson, F.M. Magaldi, E. Feitosa Jr., and A. Pessoa Protein partitioning in poly(ethylene glycol)/sodium polyacrylate aqueous two-phase systems J. Chromatogr. A 1178 2008 145 153
3. A. Negrete, T.C. Ling, and A. Lyddiatt Aqueous two-phase recovery of bio-nanoparticle: a potential miniaturization study for the recovery of bacteriophage T4 J. Chromatogr. B 854 2007 13 19
4. F. Luechau, T.C. Ling, and A. Lyddiatt Primary capture of high molecular weight nucleic acids using aqueous two-phase systems Sep. Purif. Technol. 66 2009 202 207
5. C.W. Ooi, B.T. Tey, S.L. Hii, A.H. Ariff, S.H. Wu, C.W.J. Lan, S.M. Mustapa Kamal, and T.C. Ling Purification of lipase from Burkholderia Pseudomallei with organic solvent/salt based aqueous two-phase systems Process Biochem. 44 2009 1083 1087
6. M.J. Boland, P.G.M. Hesselink, N. Papamichael, and H. Hustedt Extractive purification of enzymes from animal tissue using aqueous two phase systems: pilot scale studies J. Biotechnol. 19 1991 19 34
7. R.A. Hart, P.M. Lester, D.H. Reifsnyder, J.R. Ogez, and S.E. Builder Large scale in situ isolation of periplasmic IGF-I from E. coli Biotechnology 12 1994 1113 1117
8. H. Hustedt Extractive enzyme recovery with simple recycling of phase forming chemicals Biotechnol. Lett. 8 1986 791 796
9. M.-R. Kula Trends and future prospects of aqueous two phase extraction Bioseparation 1 1990 181 189
10. P.D. Grossman, and J.L. Gainer Correlation of aqueous two-phase partitioning of proteins with changes in free volume Biotechnol. Prog. 4 1988 6 11
11. Y.L. Gao, Q.H. Peng, Z.C. Li, and Y.G. Li Thermodynamics of ammonium sulphate-polyethylene glycol aqueous two-phase systems. Part 1. Experiment and correlation using extended UNIQUAC equation Fluid Phase Equilib. 63 1991 157 171
12. P.A. Pessoa Filho, and R.S. Mohamed Thermodynamics modelling of the partitioning of biomolecules in aqueous two-phase systems using a modified Flory-Huggins equation Process Biochem. 39 2004 2075 2083
13. A.F.M. Claudio, M.G. Freire, C.S.R. Freire, A.J.D. Silvestre, and J.A.P. Cotinho Extraction of vanillin using ionic-liquid-based aqueous two-phase systems Sep. Purif. Technol. 2010 10.1016/j.seppur.2010.07.007
14. A. Lyddiatt, and D.A. O'Sullivan Biochemical recovery and purification of gene therapy vectors Curr. Opin. Biotechnol. 9 1998 177 185
15. P. Selvakumar, T.C. Ling, S. Walker, and A. Lyddiatt Redefinition of working aqueous two-phase systems: a generic description for prediction of the effective phase chemical composition for process control and biorecovery J. Chromatogr. B 878 2010 1784 1790
16. M.J. Boland, P.G.M. Hesselink, and H. Hustedt Extractive purification of enzymes from animal tissue using aqueous two phase systems J. Biotechnol. 11 1989 337 352
17. C.A. Haynes, H.W. Blanch, and J.M. Prausnitz Separation of protein mixtures by extraction: thermodynamic properties of aqueous two-phase polymer systems containing salts and proteins Fluid Phase Equilib. 53 1989 463 474
18. M. Rito-Palomares, and A. Lyddiatt Impact of cell disruption and polymer recycling upon aqueous two phase processes for protein recovery J. Chromatogr. B 680 1996 81 89
19. B. Lebreton, S.G. Walker, and A. Lyddiatt Characterisation of aqueous two-phase partition systems by distribution analysis of radiolabelled analytes (DARA): application of to process definition and control in biorecovery Biotechnol. Bioeng. 77 2002 329 339
20. B.Y. Zaslavsky Aqueous Two Phase Partitioning: Physical Chemistry And Bio Analytical Applications 1995 Marcel Dekker, Inc. NY
21. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
22. J.G. Huddleston, A. Veide, K. Kohler, J. Flanagan, S.O. Enfors, and A. Lyddiatt The molecular basis of partitioning in aqueous two phase systems Trends Biotechnol. 9 1991 381 388
23. J.A. Flanagan, J.G. Huddleston, and A. Lyddiatt Application of aqueous two phase partition in PEG-phosphate systems: design and implementation of a prototype process for recovery of bulk protein fractionation from waste Brewers' yeast Bioseparation 2 1991 43 61
24. S. Bamberger, D.E. Brooks, K.A. Sharp, J.M. van Alstine, and J.J. Webber H. Walter, D.E. Brooks, D. Fisher, Partitioning in Aqueous Two Phase Systems: Theory, Methods, Uses and Application in Biotechnology 1985 Academic Press Orlando, FL, USA 85 130