Innate molecular and anatomic mucosal barriers against HIV infection in the genital tract of HIV-exposed seronegative individuals

Journal of Infectious Diseases

Volumn 202, Issue SUPP.3, 2010, Pages

  Broliden, Kristina ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CATHELICIDIN; DEFENSIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROGESTERONE; RANTES; VIRUS RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIVIRAL SUSCEPTIBILITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONFERENCE PAPER; DENDRITIC CELL; GENITAL SYSTEM; HIGH RISK PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INNATE IMMUNITY; LANGERHANS CELL; MACROPHAGE; MENSTRUAL CYCLE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEMINAL PLASMA; SERODIAGNOSIS; SEXUAL INTERCOURSE; SEXUAL TRANSMISSION; SEXUALLY TRANSMITTED DISEASE; SPERM; VAGINA MUCOSA; VIRUS LOAD; VIRUS TRANSMISSION; ARTICLE; DISEASE TRANSMISSION; FEMALE; HISTOLOGY; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; MALE; MUCOSA;

FEMALE; GENITALIA; HIV; HIV INFECTIONS; HUMANS; IMMUNITY, INNATE; MALE; MUCOUS MEMBRANE;

EID: 78049432114     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/655964     Document Type: Conference Paper

References (28)

1. + lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J Immunol 2000; 164:1602-1611.
2. Hirbod T, Broliden K. Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women. J Intern Med 2007; 262:44-58.
3. Haase AT. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010; 464:217-223.
4. Berlier W, Cremel M, Hamzeh H, et al. Seminal plasma promotes the attraction of Langerhans cells via the secretion of CCL20 by vaginal epithelial cells: involvement in the sexual transmission of HIV. Hum Reprod 2006; 21:1135-1142.
5. Yeaman GR, Howell AL, Weldon S et al. Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infection. Immunology 2003; 109:137-146.
6. Yeaman GR, Asin S, Weldon S, et al. Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus-type I. Immunology 2004; 113:524-533.
7. Pudney J, Quayle AJ, Anderson DJ. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol Reprod 2005; 73:1253-1263.
8. Miller CJ, McChesney M, Moore PF. Langerhans cells, macrophages and lymphocyte subsets in the cervix and vagina of rhesus macaques. Lab Invest 1992; 67:628-364.
9. Mauck CK, Callahan MM, Baker J, et al. The effect of one injection of depo-provera on the human vaginal epithelium and cervical ectopy. Contraception 1999; 60:15-24. (Pubitemid 29505351)
10. Hirbod T, Kaldensjö T, Lopalco L, et al. Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection. J Acquir Immune Defic Syndr 2009; 51:239-247.
11. Norvell MK, Benrubi GI, Thompson RJ. Investigation of microtrauma after sexual intercourse. J Reprod Med 1984; 29:269-271.
12. Pandya IJ, Cohen J. The leukocytic reaction of the human uterine cervix to spermatozoa. Fertil Steril 1985; 43:417-421. (Pubitemid 15111130)
13. Munch J, Rucker E, Standker L, et al. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell 2007; 131:1059-1071.
14. Howell AL, Edkins RD, Rier SE, et al. Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female genital reproductive tract. J Virol 1997; 71:3498-3506.
15. Patterson BK, Landay A, Siegel JN, et al. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am J Pathol 2002; 161:867-873.
16. McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. AIDS 2006; 20:1491-1495.
17. Soilleux EJ, Coleman N. Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV. J Clin Pathol 2004; 57:77-78.
18. Hirbod T, Bailey RC, Agot K, et al. Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men. Am J Pathol 2010; 176:2798-805.
19. +-dendritic cells and Langerhans cells in HIV-1 transmission. Trends Mol Med 2008; 14:12-19.
20. Ward EM, Stambach NS, Drickamer K, Taylor ME. Polymorphisms in human langerin affect stability and sugar binding activity. J Biol Chem 2006; 281:15450-15456.
21. Hirbod T, Nilsson J, Andersson S, et al. Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behaviour. J Acquir Immune Defic Syndr 2006; 43:137-143.
22. Levinson P, Kaul R, Kimani J, et al. Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. AIDS 2009; 23:309-317.
23. Iqbal SM, Ball TB, Levinson P, et al. Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition. AIDS 2009; 23:1669-1677.
24. Venkataraman N, Cole AL, Svoboda P, Pohl J, Cole AM. Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. J Immunol 2005; 175:7560-7567. (Pubitemid 41713455)
25. Cole AM, Cole AL. Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense. Am J Reprod Immunol 2008; 59:27-34.
26. Klotman ME, Rapista A, Teleshova N, et al. Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol 2008; 180:6176-6185.
27. Kaul R, Kimani J, Nagelkerke NJ, et al. Monthly antibiotic chemoprophylaxis and incidence of sexually transmitted infections and HIV-1 infection in Kenyan sex workers: a randomized controlled trial. JAMA 2004; 291:2555-2562.
28. Hirbod T, Kaul R, Reichard C, et al. HIV-neutralizing immunoglobulin A and HIV-specific proliferation are independently associated with reduced HIV acquisition in Kenyan sex workers. AIDS 2008; 22:727-735.