Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Nikoghosyan, Anna V ^a   Karapanagiotou Schenkel, Irini ^b   Münter, Marc W ^a   Jensen, Alexandra D ^a   Combs, Stephanie E ^a   Debus, Jürgen ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Patient and NCT Clinical Trial Center   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; PROTON; ION;

ARTICLE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CHORDOMA; CLINICAL EFFECTIVENESS; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; HUMAN; IMMOBILIZATION; INTERMETHOD COMPARISON; ION THERAPY; NON INVASIVE PROCEDURE; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; PATIENT ASSESSMENT; PATIENT SAFETY; PHASE 3 CLINICAL TRIAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; PROTON THERAPY; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; SKULL BASE TUMOR; CONTROLLED STUDY; DISEASE FREE SURVIVAL; METASTASIS; METHODOLOGY; RADIATION DOSE; TREATMENT OUTCOME;

CARBON; CHORDOMA; DISEASE-FREE SURVIVAL; HUMANS; IONS; NEOPLASM METASTASIS; PROSPECTIVE STUDIES; PROTONS; RADIOTHERAPY DOSAGE; RESEARCH DESIGN; SKULL BASE NEOPLASMS; TREATMENT OUTCOME;

EID: 78049406002     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-607     Document Type: Article

References (27)

1. McMaster, et al. Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Cases and Control 2001, 12:1-11.
2. Rosenberg, et al. Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol 1999, 23(11):1370-8. 10.1097/00000478-199911000-00007, 10555005.
3. Chugh, et al. Chordoma: the nonsarcoma primary bone tumor. Oncologist 2007, 12(11):1344-50. 10.1634/theoncologist.12-11-1344, 18055855.
4. Heffelfinger, et al. Chordomas and cartilaginous tumors at the skull base. Cancer 1973, 32:410-420. 10.1002/1097-0142(197308)32:2<410::AID-CNCR2820320219>3.0.CO;2-S, 4722921.
5. Borba, et al. Cranial chordomas in children and adolescence. J Neurosurg 1996, 84:584-91. 10.3171/jns.1996.84.4.0584, 8613849.
6. Samii, et al. Chordomas of the skull base: surgical management and outcome. J Neurosurg 2007, 107(2):319-24. 10.3171/JNS-07/08/0319, 17695386.
7. Noël, et al. Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol 2005, 44(7):700-8. 10.1080/02841860500326257, 16227160.
8. Colli, et al. Chordomas of the skull base: follow-up review and prognostic factors. Neurosurg Focus 2001, 10(3):E1. 10.3171/foc.2001.10.3.2, 16734401.
9. Noël, et al. Radiation therapy for chordoma and chondrosarcoma of the skull base and the cervical spine. Prognostic factors and patterns of failure. Strahlenther Onkol 2003, 179(4):241-8. 10.1007/s00066-003-1065-5, 12707713.
10. Cho, et al. Chordomas and chondrosarcomas of the skull base: comparative analysis of clinical results in 30 patients. Neurosurg Rev 2008, 31:35-43. 10.1007/s10143-007-0099-z, 17922295.
11. Casali, et al. Chordoma. Curr Opin Oncol 2007, 19(4):367-70. 10.1097/CCO.0b013e3281214448, 17545801.
12. van Herk. Different styles of image-guided radiotherapy. Semin Radiat Oncol 2007, 17(4):258-67. 10.1016/j.semradonc.2007.07.003, 17903703.
13. Munzenrider, et al. Proton therapy for tumors of the skull base. Strahlenther Onkol 1999, 175(2):57-63. 10.1007/BF03038890, 10394399.
14. Hug, et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg 1999, 91(3):432-9. 10.3171/jns.1999.91.3.0432, 10470818.
15. Weber, et al. Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skulll base: the Paul Scherrer Institute experience. Int J Radiat Oncol Biol Phys 2005, 63:401-409.
16. DeLaney, Kooy. Proton and charged particle radiotherapy. 2008,
17. Tsujii, et al. Clinical results of carbon ion therapy at NIRS. J Radiat Res 2007, 48:A1-A13.
18. Schulz-Ertner, et al. Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int J Radiat Oncol Biol Phys 2007, 68:449-457.
19. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991, 21:109-122.
20. Schoenfeld D. The asymptotic properties of nonparametric tests for comparing survival distributions. Biometrika 1981, 68:316-19.
21. Schoenfeld D. Sample-size formula for the proportional-hazards regression model. Biometrics 1983, 39:499-503. 10.2307/2531021, 6354290.
22. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
23. Cox DR. Regression models and life tables. J R Stat Soc B 1972, 34:187-220.
24. Crowley J, Ankerest DP. Handbook of statistics in clinical oncology. 2006, Chap-man & Hall/CRC, 2.
25. Fleiss JL. Statistical Methods for Rates and Proportions. 1981, Wiley, New York.
26. Hartung K, Elpelt B. Statistik, Oldenbourg, 9. 1993, Auflage, München.
27. Hosmer DW, Lemeshow D. Applied Logistic Regression. 1989, Wiley J, New York.