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Park L, Delaney TF, Liebsch NJ, et al. Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys 2006; 65:1514-1521. In 27 patients with sacral chordoma treated with proton and photon beam radiation therapy alone or combined with surgery, a high local control was achieved in those with a primary tumor as compared with recurrences, including a few patients treated with high-dose radiation therapy alone. Results are put into perspective against published series of sacral chordomas treated with radiation and/or surgical treatment, with a view to current policies and the ongoing innovative approaches.
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Tamborini E, Miselli F, Negri T, et al. Molecular and biochemical analyses of platelet-derived growth factor receptor (PDGFR) B, PDGFRA, and KIT receptors in chordomas. Clin Cancer Res 2006; 12:6920-6928. In 31 tumor samples of chordoma, PDGF receptor β was highly expressed and phosphorylated, and PDGF receptor α and KIT were less expressed but phosphorylated, in the lack of any activating mutation, thus suggesting an autocrine/ paracrine loop. This is likely the basis for imatinib's antitumor activity in the disease.
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Hof H, Welzel T, Debus J. Effectiveness of cetuximab/gefitinib in the therapy of a sacral chordoma. Onkologie 2006; 29:572-574. This case report shows a tumor response to the combination of cetuximab and gefitinib in an advanced chordoma patient, thus suggesting the possibility that targeting EGFR may result in antitumor activity, following previous demonstration about targeting PDGF receptor.
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