Study on the molecular mechanisms of dlk1 stimulated lung cancer cell proliferation

Chinese Journal of Lung Cancer

Volumn 13, Issue 10, 2010, Pages 923-927

  Liu, Yu ^a   Tan, Jinjing ^a   Li, Lin ^a   Li, Shuo ^a   Zou, Shuangmei ^a   Zhang, Ying ^a   Zhang, Xiaojing ^a   Ling, Bing ^a   Han, Naijun ^a   Guo, Suping ^a   Gao, Yanning ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

CyclinB1; dlk1; Lung neoplasms; Proliferation

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; CYCLIN B1;

ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL STRAIN H520; CLINICAL ARTICLE; COLONY FORMING CELL; DLK1 GENE; EUKARYOTE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MOLECULAR MECHANICS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GENE; WESTERN BLOTTING;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; MEMBRANE PROTEINS;

EID: 78049400705     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: 10.3779/j.issn.1009-3419.2010.10.12     Document Type: Article

References (16)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin, 2008, 58(2): 71-96.
2. Ministry of Health Press Office. The third major national cause of death investigation. China Cancer, 2008, 17(5): 4-5.
3. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med, 2008, 359(13): 1367-1380.
4. Witschi H, Espiritu I, Peake JL, et al. The carcinogenicity of environmental tobacco smoke. Carcinogenesis, 1997, 18(3): 575-586.
5. Laborda J. The role of the epidermal growth factor-like protein dlk in cell differentiation. Histol Histopathol, 2000, 15(1): 119-129. (Pubitemid 30044297)
6. Yin D, Xie D, Sakajiri S, et al. DLK1: increased expression in gliomas and associated with oncogenic activities. Oncogene, 2006, 25(13): 1852-1861.
7. Huang J, Zhang X, Zhang M, et al. Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis, 2007, 28(5): 1094-1103.
8. Jin ZH, Yang RJ, Dong B, et al. Progenitor gene DLK1 might be an independent prognostic factor of liver cancer. Expert Opin Biol Ther, 2008, 8(4): 371-377. (Pubitemid 351570403)
9. Kawakami T, Chano T, Minami K, et al. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum Mol Genet, 2006, 15(6): 821-830.
10. Lingfei K, Pingzhang Y, Zhengguo L, et al. A study on p16, pRb, cdk4 and cyclinD1 expression in non-small cell lung cancers. Cancer Lett, 1998, 130(1-2): 93-101. (Pubitemid 28425342)
11. Papay J, Krenacs T, Moldvay J, et al. Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach. Appl Immunohistochem Mol Morphol, 2007, 15(1): 19-30. (Pubitemid 46673312)
12. Jeanmart M, Lantuejoul S, Fievet F, et al. Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer. Clin Cancer Res, 2003, 9(6): 2195-2203. (Pubitemid 36687643)
13. 1/S cyclins in human primary lung carcinomas. J Pathol, 2003, 199(2): 208-220.
14. Cangi MG, Cukor B, Soung P, et al. Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest, 2000, 106(6): 753-761.
15. Kim KA, Kim JH, Wang Y, et al. Pref-1 (preadipocyte factor 1) activates the MEK/extracellular signal-regulated kinase pathway to inhibit adipocyte differentiation. Mol Cell Biol, 2007, 27(6): 2294-2308. (Pubitemid 46418483)
16. Ruiz-Hidalgo MJ, Gubina E, Tull L, et al. dlk modulates mitogen-activated protein kinase signaling to allow or prevent differentiation. Exp Cell Res, 2002, 274(2): 178-188.