Cross-over evaluation of electrically induced pain and hyperalgesia

Scandinavian Journal of Pain

Volumn 1, Issue 4, 2010, Pages 205-210

  Dusch, M ^a   Namer, B ^a,b   Strupf, M ^b   Schley, M ^a   Rukwied, R ^a   Hagglof B ^c   Schmelz, M ^a   Koppert, W ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c ASTRAZENECA R AND D   (Sweden)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Axon reflex; Cross over study design; Hyperalgesia; Pain; Paracetamol

Indexed keywords

PARACETAMOL; SUCROSE;

ALLODYNIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELECTROSTIMULATION; EXPERIMENTAL DESIGN; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; NERVE FIBER; NORMAL HUMAN; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 78049390734     PISSN: 18778860     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sjpain.2010.08.002     Document Type: Article

References (20)

1. Bickel A., Dorfs S., Schmelz M., Forster C., Uhl W., Handwerker H.O. Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Pain 1998, 76:317-325.
2. Chizh B.A., Dusch M., Puthawala M., Schmelz M., Cookson L.M., Martina R., Brown J., Koppert W. The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization. Anesth Analg 2004, 99:816-822. [table].
3. Chizh B.A., Gohring M., Troster A., Quartey G.K., Schmelz M., Koppert W. Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers. Br J Anaesth 2007, 98:246-254.
4. De C.R., Maihofner C. Centrally mediated sensory decline induced by differential C-fiber stimulation. Pain 2008, 138:556-564.
5. Eisenbarth H., Rukwied R., Petersen M., Schmelz M. Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin. Pain 2004, 110:197-204.
6. Forster C., Magerl W., Beck A., Geisslinger G., Gall T., Brune K., Handwerker H.O. Differential effects of dipyrone, ibuprofen, and paracetamol on experimentally induced pain in man. Agents Actions 1992, 35:112-121.
7. Geber C., Magerl W., Fondel R., Fechir M., Rolke R., Vogt T., Treede R.D., Birklein F. Numbness in clinical and experimental pain-a cross-sectional study exploring the mechanisms of reduced tactile function. Pain 2008, 139:73-81.
8. Hughes A., Macleod A., Growcott J., Thomas I. Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain. Pain 2002, 99:323-331.
9. Jensen T.S., Gottrup H., Sindrup S.H., Bach F.W. The clinical picture of neuropathic pain. Eur J Pharmacol 2001, 429:1-11.
10. Koppert W., Dern S.K., Sittl R., Albrecht S., Schuttler J., Schmelz M. A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. Anesthesiology 2001, 95:395-402.
11. Koppert W., Filitz J., Troster A., Ihmsen H., Angst M., Flor H., Schuttler J., Schmelz M. Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain model. J Pain 2005, 6:757-764.
12. Koppert W., Wehrfritz A., Korber N., Sittl R., Albrecht S., Schuttler J., Schmelz M. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain 2004, 108:148-153.
13. Millan M.J. The induction of pain: an integrative review. Prog Neurobiol 1999, 57:1-164.
14. Moller P.L., Sindet-Pedersen S., Petersen C.T., Juhl G.I., Dillenschneider A., Skoglund L.A. Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. Br J Anaesth 2005, 94:642-648.
15. Petersen K.L., Brennum J., Dahl J.B. Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia. Pain 1997, 70:167-174.
16. Rose S.R. Subtleties of managing acetaminophen poisoning. Am J Hosp Pharm 1994, 51:3065-3068.
17. Segerdahl M. Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. Pain 2006, 125:158-164.
18. Troster A., Sittl R., Singler B., Schmelz M., Schuttler J., Koppert W. Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. Anesthesiology 2006, 105:1016-1023.
19. Weidner C., Schmelz M., Schmidt R., Hansson B., Handwerker H.O., Torebjork H.E. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci 1999, 19:10184-10190.
20. Woolf C.J., Bennett G.J., Doherty M., Dubner R., Kidd B., Koltzenburg M., Lipton R., Loeser J.D., Payne R., Torebjork E. Towards a mechanism-based classification of pain?. Pain 1998, 77:227-229.