Rate-dependent and antiarrhythmic reentrant tachycardia (AVNRT) effects of simvastatin in isolated rabbit atrioventricular nodal model

Journal of Mazandaran University of Medical Sciences

Volumn 20, Issue 76, 2010, Pages 78-87

  Khori, Vahid ^a   Najafi, Soroosh Aminosharihe ^a   Alizadeh, Fatemeh ^a   Pourabouk, Mona ^a   Nayebpour, Mohsen ^b   Changizi, Shima ^c   Salehi, Aref ^a   Badaghabadi, Fakhri ^a   Alizadeh, Ali Mohammad ^d  

^a GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Hakim Jorjani Hospital   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Atrioventricular node; AVNRT; Simvastatin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEART ATRIOVENTRICULAR NODE; HEART ELECTROPHYSIOLOGY; HEART SUPRAVENTRICULAR ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; NONHUMAN; RABBIT; WENCKEBACH PERIOD;

EID: 78049385754     PISSN: 17359279     EISSN: 17359260     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ludman A, Venugopal V, Yellon DM, Hausenloy DJ. Statins and cardioprotection - more than just lipid lowering? Pharmacol Ther 2009; 122(1): 30-43.
2. Kostapanos MS, Liberopoulos EN, Goudevenos JA, Mikhailidis DP, Elisaf MS. Do statins have an antiarrhythmic activity? Cardiovasc Res 2007; 75(1): 10-20.
3. Sánchez-Quiñones J, Marín F, Roldán V, Lip GY. The impact of statin use on atrial fibrillation. QJM 2008; 101(11): 845-861.
4. Rosenson R.S. Statins in atherosclerosis: lipid-lowering agents with antioxidant capabilities. Atherosclerosis 2004; 173(1): 1-12.
5. Plenge J.K, Hernandez T.L, Weil K.M, Poirier P, Grunwald G.K, Marcovina S.M, et al. Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction. Circulation 2002; (106): 1447-1452.
6. Lozano H.F, Conde C.A, Florin T, Lamas G.A. Treatment and prevention of atrial fibrillation with nonantiarrhythmic pharmacologic therapy. Heart Rhythm 2005; 2(9): 1000-1007. (Pubitemid 41372292)
7. Adameová A, Kuzelová M, Faberová V, Svec P. Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 2006; 61(9): 807-808. (Pubitemid 44450377)
8. Liu YB, Lee YT, Pak HN, Lin SF, Fishbein MC, Chen LS, et al. Effects of simvastatin on cardiac neural and electrophysiologic remodeling in rabbits with hypercholesterolemia. Heart Rhythm 2009; 6(1): 69-75.
9. Tesfamariam B, Frohlich BH, Gregg RE. Differential effects of pravastatin, simvastatin, and atorvastatin on Ca2+ release and vascular reactivity. J Cardiovasc Pharmacol 1999; 34(1): 95-101. (Pubitemid 29296143)
10. Vaquero M, Caballero R, Gómez R, Núñez L, Tamargo J, Delpón E. Effects of atorvastatin and simvastatin on atrial plateau currents. J Mol Cell Cardiol 2007; 42(5): 931-945. (Pubitemid 46678036)
11. Shiroshita-Takeshita A, Schram G, Lavoie J, Nattel S. Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs. Circulation 2004; 110(16): 2313-2319. (Pubitemid 39407332)
12. Pound EM, Kang JX, Leaf A. Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. J Lipid Res 2001; 42(3): 346-351. (Pubitemid 32270057)
13. Thuc LC, Teshima Y, Takahashi N, Nagano-Torigoe Y, Ezaki K, Yufu K, et al. Mitochondrial KATP channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection. Apoptosis 2010; 15(6): 669-678.
14. Kuhn EW, Liakopoulos OJ, Borys MJ, Haldenwang PL, Strauch JT, Madershahian N, et al. Statins improve surgical ablation outcomes for atrial fibrillation in patients undergoing concomitant cardiac surgery. Interact Cardiovasc Thorac Surg 2010; 8.
15. Mital S, Zhang X, Zhao G, Bernstein RD, Smith CJ, Fulton DL, et al. Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs. Am J Physiol heart circ Physiol 2000; 279: H2649-H2657.
16. Liu T, Li GP. Statins may prevent postoperative atrial fibrillation through autonomic modulation. Am J Cardiol 2006; 97(8): 1266.
17. Sánchez-Quiñones J, Marín F, Roldán V, Lip GY. The impact of statin use on atrial fibrillation. QJM 2008; 101(11): 845-861.
18. Khori V, Nayebpour M, Rakhshan E, Mirabbasi A. The Role of Nitric Oxide syntase enzyme inhibitor on antiarrhytmic effects of Crocus Sativuse on isolated rabbit atrioventricular Node. Journal of Guilan University of Medical Sciences 2007; 16: 1-10 (Persian).
19. Talajic M, Lemery R, Roy D, Villemaire C, Cartier R, Coutu B, et al. Rate-dependent effects of diltiazem on human atrioventricular nodal properties. Circulation 1992; 86(3): 870-877.
20. Nayebpour M, Billette J, Amellal F, Nattel S. Effects of adenosine on rate-dependent atrioventricular nodal function. Potential roles in tachycardia termination and physiological regulation. Circulation 1993; 88(6): 2632-2645.
21. Savelieva I, Camm J. Statins and polyunsaturated fatty acids for treatment of atrial fibrillation. Nat Clin Pract Cardiovasc Med 2008; 5(1): 30-41.
22. Tadros R, Billette J. Rate-dependent AV nodal refractoriness: a new functional framework based on concurrent effects of basic and pretest cycle length. Am J Physiol Heart Circ Physiol 2009; 297(6): H2136-2143.
23. Talajic M, Papadatos D, Villemaire C, Nayebpour M, Nattel S. Antiarrhythmic actions of diltiazem during experimental atrioventricular reentrant tachycardias. Importance of use-dependent calcium channel-blocking properties. Circulation 1990; 81(1): 334-342.
24. Nayebpour M, Talajic M, Nattel S. Effects of beta-adrenergic receptorstimulation and blockade on rate-dependent atrioventricular nodal properties. Circ Res 1992; 70(5): 902-911.
25. Nayebpour M, Talajic M, Villemaire C, Nattel S. Vagal modulation of the rate-dependent properties of the atrioventricular node. Circ Res 1990; 67(5): 1152-1166. (Pubitemid 20368013)
26. Nayebpour M, Naseri M, Khori V. Effects of ajmaline on rate-dependent atrioventricular node properties. Potential role in experimental atrioventricular re-entrant tachycardia. Eur J Pharmacol 2001; 412(1): 77-89. (Pubitemid 32149772)
27. Reid MC, Billette J, Khalife K, Tadros R. Role of compact node and posterior extension in direction-dependent changes in atrioventricular nodal function in rabbit. J Cardiovasc Electrophysiol 2003; 14(12): 1342-1350. (Pubitemid 38037473)
28. Zhang Y, Mazgalev TN. Ventricular rate control during atrial fibrillation and AV node modifications: past, present, and future. Pacing Clin Electrophysiol 2004; 27: 382-393. (Pubitemid 38352522)
29. Medkour D, Becker AE, Khalife K, Billette J. Anatomic and functional characteristics of a slow posterior AV nodal pathway: Role in dual-pathway physiology and reentry. Circulation 1998; 98(2): 164-174. (Pubitemid 28317897)
30. Khalife K, Billette J, Medkour D, Martel K, Tremblay M, Wang J, et al. Role of the compact node and its posterior extension in normal atrioventricular nodal conduction, refractory, and dual pathway properties. J Cardiovasc Electrophysiol 1999; 10(11): 1439-1451.
31. Mazgalev T, Mowrey K, Efimov I, Fahy GJ, Van Wagoner D, Cheng Y, et al. Mechanism of atrioventricular nodal facilitation in rabbit heart: role of proximal AV node. Am J Physiol 1997; 273(4 Pt 2): H1658-1668.
32. Billette J, Métayer R, St-Vincent M. Selective functional characteristics of rate-induced fatigue in rabbit atrioventricular node. Circ Res 1988; 62(4): 790-799.