Prognostic effect of exercise capacity on mortality in older adults with diabetes mellitus

Journal of the American Geriatrics Society

Volumn 58, Issue 10, 2010, Pages 1850-1854

  Nylen, Eric S ^a,b   Kokkinos, Peter ^a,c   Myers, Jonathan ^b,d,e   Faselis, Charles ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^e STANFORD UNIVERSITY   (United States)

Author keywords

Diabetes; Elderly; Exercise capacity; Mortality

Indexed keywords

ADULT; AGED; ARTICLE; DIABETES MELLITUS; EXERCISE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHYSICAL ACTIVITY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SENESCENCE; CAUSE OF DEATH; CLINICAL TRIAL; COMPARATIVE STUDY; DISABILITY; EXERCISE TEST; EXERCISE TOLERANCE; FITNESS; FOLLOW UP; KINESIOTHERAPY; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY; SURVIVAL RATE; UNITED STATES; VETERAN;

AGED; AGED, 80 AND OVER; CALIFORNIA; CAUSE OF DEATH; DIABETES MELLITUS, TYPE 2; DISABILITY EVALUATION; DISTRICT OF COLUMBIA; EXERCISE TEST; EXERCISE THERAPY; EXERCISE TOLERANCE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PHYSICAL FITNESS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; VETERANS;

EID: 78049378650     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2010.03068.x     Document Type: Article

References (25)

1. Kokkinos P., Physical Activity and Cardiovascular Disease Prevention. Canada: Jones and Bartlett Publishers, 2010.
2. Fleg JL, Lakatta EG., Role of muscle loss in the age-associated reduction in VO2 max. J Appl Physiol 1988; 65: 1147 - 1151.
3. Park SW, Goodpaster BH, Strotmyer ES, et al,. Accelerated loss of muscle strength in older adults with type 2 diabetes; the Health, Aging, and Body Composition study. Diabetes Care 2007; 30: 1507 - 1512.
4. Park SW, Goodpaster BH, Strotmyer ES, et al,. Decreased muscle strength and quantity in older adults with type 2 diabetes; the Health, Aging, and Body Composition study. Diabetes 55: 1813 - 1818.
5. Sayer AA, Dennison EM, Gilbody HJ, et al,. Type 2 diabetes, muscle strength, and impaired physical function. Diabetes Care 2005; 28: 2541 - 2542.
6. Estacio RO, Wolfel EE, Regensteiner JG, et al,. Effect of risk factors on exercise capacity in NIDDM. Diabetes 1996; 45: 79 - 85.
7. King DE, Mainous AG III, Carnemolla M, et al,. Adherence to healthy lifestyle habits in US adults, 1988-2006. Am J Med 2009; 122: 528 - 534.
8. Sui X, LaMonte MJ, Laditka JN, et al,. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA 2007; 298: 2507 - 2516.
9. Kokkinos P, Myers J, Kokkinos JP, et al,. Exercise capacity and mortality in black and white men. Circulation 2008; 117: 614 - 622.
10. Myers J, Prakash M, Froelicher V, et al,. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 2002; 346: 793 - 801.
11. Gibbons RJ, Balady GJ, Bricker JT, et al,. American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). ACC/AHA 2002 guideline update for exercise testing: summary article: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation 2002; 106: 1883 - 1892.
12. Morris CK, Myers J, Froelicher VF, et al,. Nomogram based on metabolic equivalents and age for assessing aerobic exercise capacity in men. J Am Coll Cardiol 1993; 22: 175 - 182.
13. Boushel R, Gnaiger E, Scherling P, et al,. Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 2007; 50: 790 - 796.
14. Tanaka H, Seals DR., Dynamic exercise performance in masters atheletes: Insight into the effects of primary human aging on physiological functional capacity. J Appl Physiol 2003; 95: 2152 - 2162.
15. Kokkinos P, Myers J, Doumas M, et al,. Exercise capacity and all-cause mortality in pre-hypertensive men. Am J Hypertension 2009; 22: 735 - 741.
16. Kokkinos P, Myers J, Nylen E, et al,. Exercise capacity and all-cause mortality in African-American and Caucasian men with type 2 diabetes mellitus. Diabetes Care 2009; 32: 623 - 628.
17. Kokkinos P, Manolis A, Pittaras A, et al,. Exercise capacity and mortality in men with and without additional risk factors. Hypertension 2009; 53: 494 - 499.
18. Mandic S, Myers JN, Oliveira RB, et al,. Characterizing differences in mortality at the low end of the fitness spectrum. Med Sci Sports Exerc 2009; 41: 1573 - 1579.
19. Knowler WC, Barrett-Connor E, Fowler SE, et al,. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393 - 403.
20. Lanza IR, Nair KS., Muscle mitochondrial changes with aging and exercise. Am J Clin Nutr 2009; 89: 467S - 471S.
21. Lanza IR, Short DK, Short KR, et al,. Endurance exercise as a countermeasure for aging. Diabetes 2008; 57: 2933 - 2942.
22. Church TS, Cheng YJ, Earnest CP, et al,. Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care 2004; 27: 83 - 88.
23. Church TS, LaMonte MJ, Barlow CE, et al,. Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med 2005; 165: 2114 - 2120.
24. Wei M, Gibbons LW, Kampert JB, et al,. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med 2000; 132: 605 - 611.
25. Lauer MS, Blackstone EH, Young JB, et al,. Cause of death in clinical research: Time for a reassessment?. J Am Coll Cardiol 1999; 34: 618 - 620.