Measuring the efficacy of anti-malarial drugs in vivo: Quantitative PCR measurement of parasite clearance

Malaria Journal

Volumn 9, Issue 1, 2010, Pages

  Beshir, Khalid B ^a   Hallett, Rachel L ^a   Eziefula, Alice C ^a,b   Bailey, Robin ^a,b   Watson, Julie ^b   Wright, Stephen G ^b   Chiodini, Peter L ^a,b   Polley, Spencer D ^b   Sutherland, Colin J ^a,b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b HOSPITAL FOR TROPICAL DISEASES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; BETA TUBULIN; DNA; METHIONINE TRANSFER RNA; PYRIMETHAMINE; QUININE; SULFADOXINE; PROTOZOAL DNA;

ARTICLE; BLOOD SAMPLING; CASE REPORT; DRUG EFFICACY; FLUORESCENCE; GENE SEQUENCE; GENE TARGETING; HUMAN; IN VIVO STUDY; MALARIA FALCIPARUM; MICROSCOPY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA CLEARANCE; PLASMODIUM; PLASMODIUM FALCIPARUM; PLASMODIUM KNOWLESI; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM OVALE MALARIA; PLASMODIUM VIVAX; POLYMERASE CHAIN REACTION; DRUG EFFECT; DRUG SENSITIVITY; GENE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY;

ANTIMALARIALS; DNA, PROTOZOAN; GENES, PROTOZOAN; HUMANS; PARASITIC SENSITIVITY TESTS; PLASMODIUM; POLYMERASE CHAIN REACTION; RNA, TRANSFER, MET;

EID: 78049368686     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-9-312     Document Type: Article

References (17)

1. WHO, Guidelines for the treatment of malaria World Health Organization, Geneva Second 2010 ISBN: 9789241547925
2. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. NJ White, Antimicrob Agents Chemother 1997 41 1413 22 9210658
3. Averting a malaria disaster. NJ White F Nosten S Looareesuwan WM Watkins K Marsh RW Snow G Kokwaro J Ouma TT Hien ME Molyneux TE Taylor CI Newbold TK Ruebush M Danis BM Greenwood RM Anderson P Olliaro, Lancet 1999 353 1965 1967 10.1016/S0140-6736(98)07367-X 10371589
4. Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. AP Alker P Lim R Sem NK Shah P Yi DM Bouth R Tsuyuoka JD Maguire T Fandeur F Ariey C Wongsrichanalai SR Meshnick, Am J Trop Med Hyg 2007 76 641 647 17426163
5. Evidence of artemisinin-resistant malaria in western Cambodia. H Noedl Y Se K Schaecher BL Smith D Socheat MM Fukuda Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium, N Engl J Med 2008 359 2619 2620 10.1056/NEJMc0805011 19064625
6. Artemisinin resistance in Plasmodium falciparum malaria. AM Dondorp F Nosten P Yi D Das AP Phyo J Tarning KM Lwin F Ariey W Hanpithakpong SJ Lee P Ringwald K Silamut M Imwong K Chotivanich P Lim T Herdman SS An S Yeung P Singhasivanon NP Day N Lindegardh D Socheat NJ White, N Engl J Med 2009 361 455 467 10.1056/NEJMoa0808859 19641202
7. In vivo parasitological measures of artemisinin susceptibility. K Stepniewska E Ashley SJ Lee N Anstey KI Barnes TQ Binh U D'Alessandro NP Day PJ de Vries G Dorsey JP Guthmann M Mayxay PN Newton P Olliaro L Osorio RN Price M Rowland F Smithuis WR Taylor F Nosten NJ White, J Infect Dis 2010 201 570 579 10.1086/650301 20085495
8. Treatment of malaria in Gambian children with chloroquine plus sulphadoxine-pyrimethamine favours survival and transmission to mosquitoes of multi-drug-resistant Plasmodium falciparum. RL Hallett S Dunyo R Ord M Jawara M Pinder A Randall A Alloueche G Walraven GAT Targett N Alexander CJ Sutherland, PLoS Clin Trials 2006 1 15 10.1371/journal.pctr.0010015 16871318
9. Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum. NB Gadalla SE Elzaki E Mukhtar DC Warhurst B El-Sayed CJ Sutherland, Malaria J 2010 9 74 10.1186/1475-2875-9-74
10. -CT Method. KJ Livak TD Schmittgen, Method 2001 24 402 408 10.1006/meth.2001.1262 (Pubitemid 34164012)
11. Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the UK. CJ Sutherland H Fifer RJ Pearce F bin Reza M Nicholas T Haustein NE Njimgye-Tekumafor JF Doherty P Gothard SD Polley PL Chiodini, Antimicr Agents Chemother 2009 53 3405 3410 10.1128/AAC.00024-09
12. MapSeq/pf. http://www.sanger.ac.uk/MapSeq/ (last accessed 03/11/2010)
13. Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. CJ Sutherland N Tanomsing D Nolder M Oguike C Jennison S Pukrittayakamee C Dolecek TT Hien VE do Rosrio AP Arez J Pinto P Michon AA Escalante F Nosten M Burke R Lee M Blaze TD Otto JW Barnwell A Pain J Williams NJ White NP Day G Snounou PJ Lockhart PL Chiodini M Imwong SD Polley, J Infect Dis 2010 201 1544 1550 10.1086/652240 20380562
14. Establishment of the 1st World Health Organization International Standard for Plasmodium falciparum DNA for nucleic acid amplification technique (NAT)-based assays. DJ Padley AB Heath C Sutherland PL Chiodini SA Baylis the Collaborative Study Group, Malar J 2008 7 139 10.1186/1475-2875-7-139 18652656
15. Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum. JT Bousema P Schneider LC Gouagna CJ Drakeley A Tostmann R Houben JI Githure R Ord CJ Sutherland SA Omar RW Sauerwein, J Infect Dis 2006 193 1151 1159 10.1086/503051 16544256
16. Qinghaosu (artemisinin): the price of success. NJ White, Science 2008 320 330 334 10.1126/science.1155165 18420924
17. High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. TJ Anderson S Nair S Nkhoma JT Williams M Imwong P Yi D Socheat D Das K Chotivanich NP Day NJ White AM Dondorp, J Infect Dis 2010 201 1326 1330 10.1086/651562 20350192