Normal weight obesity: Relationship with lipids, glycaemic status, liver enzymes and inflammation

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 20, Issue 9, 2010, Pages 669-675

  Marques Vidal, P ^a,b   Pecoud A ^c   Hayoz, D ^d   Paccaud, F ^b   Mooser, V ^e   Waeber, G ^d   Vollenweider, P ^d  

^a CardioMet   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Adiponectin; Cross sectional study; Epidemiology; Inflammation; Leptin; Lipid markers; Liver markers; Normal weight obesity; Switzerland

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; LIPID;

ADULT; AGED; ARTICLE; BLOOD; BODY FAT DISTRIBUTION; BODY WEIGHT; CARDIOVASCULAR DISEASE; ENZYMOLOGY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; LIVER; MALE; MIDDLE AGED; OBESITY; RISK FACTOR; SEX DIFFERENCE;

ADIPONECTIN; ADULT; AGED; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BODY FAT DISTRIBUTION; BODY WEIGHT; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; INFLAMMATION; LIPIDS; LIVER; MALE; MIDDLE AGED; OBESITY; RISK FACTORS; SEX FACTORS;

EID: 78049358725     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2009.06.001     Document Type: Article

References (29)

1. De Lorenzo A., Martinoli R., Vaia F., Di Renzo L. Normal weight obese (NWO) women: an evaluation of a candidate new syndrome. Nutr Metab Cardiovasc Dis 2006 Dec, 16(8):513-523.
2. Di Renzo L., Del Gobbo V., Bigioni M., Premrov M.G., Cianci R., De Lorenzo A. Body composition analyses in normal weight obese women. Eur Rev Med Pharmacol Sci 2006 Jul, 10(4):191-196.
3. De Lorenzo A., Del Gobbo V., Premrov M.G., Bigioni M., Galvano F., Di Renzo L. Normal-weight obese syndrome: early inflammation?. Am J Clin Nutr 2007 Jan, 85(1):40-45.
4. Berg A.H., Scherer P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005 May 13, 96(9):939-949.
5. Di Renzo L., Bigioni M., Del Gobbo V., Premrov M.G., Barbini U., Di Lorenzo N., et al. Interleukin-1 (IL-1) receptor antagonist gene polymorphism in normal weight obese syndrome: relationship to body composition and IL-1 alpha and beta plasma levels. Pharm Res 2007 Feb, 55(2):131-138.
6. Firmann M., Mayor V., Marques-Vidal P., Bochud M., Pécoud A., Hayoz D., et al. The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 2008 Mar 17, 8(1):6.
7. Lohman T.G., Roche A.F., Martorell R. Anthropometric standardization reference manual 1991, Human Kinetics Books, Champaign, IL, (abridged edition).
8. Smye S.W., Sutcliffe J., Pitt E. A comparison of four commercial systems used to measure whole-body electrical impedance. Physiol Meas 1993 Nov, 14(4):473-478.
9. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization Technical Report Series; 2000;894:i-253.
10. Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). J Am Med Assoc 2001 May 16, 285(19):2486-2497.
11. Wildman R.P., Muntner P., Reynolds K., McGinn A.P., Rajpathak S., Wylie-Rosett J., et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 2008 Aug 11, 168(15):1617-1624.
12. Korenfeld Y., Romero-Corral A., Sierra-Johnson J., Xu L., Boarin S., Lopez-Jimenez F. Normal weight obesity is associated with adverse cardiometabolic profiles in individuals with cardiovascular disease. Obesity 2008, 16:S323.
13. Romero-Corral A., Montori V.M., Somers V.K., Korinek J., Thomas R.J., Allison T.G., et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006 Aug 19, 368(9536):666-678.
14. Goodpaster B.H., Krishnaswami S., Harris T.B., Katsiaras A., Kritchevsky S.B., Simonsick E.M., et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005 Apr 11, 165(7):777-783.
15. St-Onge M.P., Janssen I., Heymsfield S.B. Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual. Diabetes Care 2004 Sep, 27(9):2222-2228.
16. Iacobellis G., Ribaudo M.C., Zappaterreno A., Iannucci C.V., Leonetti F. Prevalence of uncomplicated obesity in an Italian obese population. Obes Res 2005 Jun, 13(6):1116-1122.
17. Ostlund R.E., Yang J.W., Klein S., Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 1996 Nov, 81(11):3909-3913.
18. Mahabir S., Baer D., Johnson L.L., Roth M., Campbell W., Clevidence B., et al. Body mass index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study. Nutr J 2007, 6:3.
19. Cnop M., Havel P.J., Utzschneider K.M., Carr D.B., Sinha M.K., Boyko E.J., et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003 Apr, 46(4):459-469.
20. Hanley A.J., Bowden D., Wagenknecht L.E., Balasubramanyam A., Langfeld C., Saad M.F., et al. Associations of adiponectin with body fat distribution and insulin sensitivity in non-diabetic Hispanic and African Americans. J Clin Endocrinol Metab 2007 Jul, 92(7):2665-2671.
21. Machado M., Marques-Vidal P., Cortez-Pinto H. Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol 2006 Oct, 45(4):600-606.
22. Nakao K., Nakata K., Ohtsubo N., Maeda M., Moriuchi T., Ichikawa T., et al. Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults. Am J Gastroenterol 2002 Jul, 97(7):1796-1801.
23. Bratberg G.H., Nilsen T.I., Holmen T.L., Vatten L.J. Early sexual maturation, central adiposity and subsequent overweight in late adolescence. A four-year follow-up of 1605 adolescent Norwegian boys and girls: the Young HUNT study. BMC Public Health 2007, 7:54.
24. Gunderson E.P., Abrams B. Epidemiology of gestational weight gain and body weight changes after pregnancy. Epidemiol Rev 2000, 22(2):261-274.
25. Virk S., Schwartz T.L., Jindal S., Nihalani N., Jones N. Psychiatric medication induced obesity: an aetiologic review. Obes Rev 2004 Aug, 5(3):167-170.
26. Udden J., Björntorp P., Arner P., Barkeling B., Meurling L., Rössner S. Effects of glucocorticoids on leptin levels and eating behaviour in women. J Intern Med 2003 Feb, 253(2):225-231.
27. Wolf H.K., Kuulasmaa K., Tolonen H., Ruokokoski E. Participation rates, quality of sampling frames and sampling fractions in the MONICA surveys 1998 Sep 15, WHO MONICA, Helsinki, Finland.
28. Abate N., Garg A., Peshock R.M., Stray-Gundersen J., Adams-Huet B., Grundy S.M. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 1996 Dec, 45(12):1684-1693.
29. 2) Asian Indians with normal waist circumference have high cardiovascular risk. Nutrition 2003 Jun, 19(6):503-509.