Evaluation of highly-water soluble drug physical state in biodegradable microcapsules

IFMBE Proceedings

Volumn 20 IFMBE, Issue , 2008, Pages 619-622

  Loca, Dagnija ^a   Pugovics, O ^b   Berzina Cimdina, L ^a  

^a RIGA TECHNICAL UNIVERSITY   (Latvia)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

differential scanning calorimetry. X Ray diffractometry; drug delivery; microencapsulation

Indexed keywords

BIOMEDICAL ENGINEERING; CALORIMETERS; CRYSTALLINITY; DICHLOROMETHANE; DIFFERENTIAL SCANNING CALORIMETRY; EMULSIFICATION; GLASS TRANSITION; MEDICAL PHYSICS; MICROENCAPSULATION; MICROSTRUCTURE; POLYMERS; SCANNING ELECTRON MICROSCOPY; SURFACE ACTIVE AGENTS; X RAY DIFFRACTION ANALYSIS;

BIODEGRADABLE MICROCAPSULES; COATING MATERIAL; DRUG-POLYMER INTERACTION; HIGH DRUG LOADINGS; POLY(LACTIC ACID); POLYMER CRYSTALLINITY; WATER SOLUBLE DRUGS; WATER-IN-OIL-IN-WATER;

DRUG DELIVERY;

EID: 78049354416     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-540-69367-3_165     Document Type: Conference Paper

References (12)

1. Pistel K F, Kissel T. (2000) Effect of salt addition on the microencapsulation of proteins using w/o/w double emulsion technique. J.Microencapsulation 17:467-483
2. Chaw C S, Yang Y Y, Lim I J et al (2003) Water-soluble betamethasone-loaded poly(lactide-co-glycolide) hollow microparticles as a sustained release dosage form. J.Microencapsulation 20:349-359
3. Sato T, Kanke M, Schroeder H J et al. (1988) Porous biodegradable microspheres for controlled drug delivery. I. Assessment of processing conditions and solvent removal techniques. Pharm. Res 5:21-30
4. Chen X O, Yang Y Y, Wang L et al. (2001) Effects of inner water volume on the peculiar surface morphology of microspheres fabricated by double emulsion technique. J.Microencapsulation 18:637-649 (Pubitemid 33150495)
5. Soppimath K S, Aminabhavi T M. (2002) Ethyl acetate as a dispersing solvent in the production of poly(dl-lactide-co-glycolide) microspheres: effect of process parameters and polymer type. J.Microencapsulation 19:281-292
6. Blanco M D, Sastre R L, Teijon C et al. (2006) Degradation behaviour of microspheres prepared by spray-drying poly(D,L-lactide) and poly(D,L-lactide-co- glycolide) polymers. Int J Pharm 326:139-147 (Pubitemid 44647754)
7. Nihant N, Schugens C, Grandfils C et al. (1994) Polylactide microparticles prepared by double emulsion/evaporation technique. I. Effect of primary emulsion stability. Pharm. Res. 11:1479-1484
8. Brown M D (2003) Drug delivery systems in cancer therapy. Humana Press Inc., Totowa, NJ
9. Lamprecht A, Schefer U, Lehr C. (2000) Structural analysis of microparticles by confocal laser scanning microscopy. AAPS Pharmsci 6:article 17 (Pubitemid 41086031)
10. Watts P J, Davies M C, Melia C D. Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications. (1990) Crit Rev Ther Drug 7:235-259
11. Tayade P T, Kale D R. (2004) encapsulation of water-insoluble drug by cross-linking technique: effect of process and formulation variables on encapsulation efficiency, particle size and in vitro dissolution rate. AAPS Pharmsci 6:article 12
12. O'Donnell P B, McGinity J W. (1997) Preparation of microspheres by the solvent evaporation technique. Adv Drug deliver rev 28:25-42