Association of physical training with beta-blockers in heart failure in mice;Asociación de betabloqueantes y entrenamiento físico en la insuficiencia cardíaca de ratones

Arquivos Brasileiros de Cardiologia

Volumn 95, Issue 3, 2010, Pages 373-380

  Vanzelli, Andréa Somolanji ^a   Medeiros, Alessandra ^b   Sirvente, Raquel De Assis ^a   Salemi, Vera Maria Cury ^a   Mady, Charles ^a   Brum, Patricia Chakur ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

blockers e mice; Exercise; Heart failure; Sympathetic nervous system; Training

Indexed keywords

CARVEDILOL; METOPROLOL;

AEROBIC EXERCISE; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; ECHOCARDIOGRAPHY; EXERCISE TOLERANCE; GENETIC MODEL; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HISTOLOGY; MALE; MOUSE; NONHUMAN; POST HOC ANALYSIS; TREADMILL EXERCISE;

ADRENERGIC BETA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; CARBAZOLES; COLLAGEN; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; HEART FAILURE; MALE; METOPROLOL; MICE; MYOCYTES, CARDIAC; PHYSICAL CONDITIONING, ANIMAL; PROPANOLAMINES; RANDOM ALLOCATION; VENTRICULAR REMODELING;

EID: 78049349223     PISSN: 0066782X     EISSN: 16784170     Source Type: Journal    
DOI: 10.1590/S0066-782X2010005000098     Document Type: Article

References (40)

1. Adamopoulos S, Parissis JT, Kremastinos DT. New aspects for the role of physical training in the management of patients with chronic heart failure. Int J Cardiol. 2003; 90 (1): 1-14. (Pubitemid 36734837)
2. Opie LH, Walpoth B, Barsacchi R. Calcium and catecholamines: relevance to cardiomyopathies and significance in therapeutic strategies. J Mol Cell Cardiol. 1985; 17 (Suppl 2): 21-34.
3. Katz AM. Evolving concepts of heart failure: cooling furnace, malfunctioning pump, enlarging muscle - Part I. J Card Fail. 1997; 3 (4): 319-34.
4. Grimm D, Huber M, Jabusch HC, Shakibaei M, Fredersdorf S, Paul M, et al. Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload: effects of beta-receptor blockade. J Mol Cell Cardiol. 2001; 33 (3): 487-501.
5. Kunst G, Kress KR, Gruen M, Uttenweiler D, Gautel M, Fink RH. Myosin binding protein C, a phosphorylation-dependent force regulator in muscle that controls the attachment of myosin heads by its interaction with myosin S2. Circ Res. 2000; 86 (1): 51-8.
6. Rationale, design, and organization of the Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF). The International Steering Committee. Am J Cardiol. 1997; 80 (9B): 54J-8J.
7. Carvedilol saves lives - new data from landmark trials prove survival benefits in heart failure and post myocardial infarction. Cardiovasc J S Afr. 2001; 12 (2): 122-3.
8. Anderson JL, Lutz JR, Gilbert EM, Sorensen SG, Yanowitz FG, Menlove RL, et al. A randomized trial of low-dose beta-blockade therapy for idiopathic dilated cardiomyopathy. Am J Cardiol. 1985; 55 (4): 471-5.
9. Cesario DA, Fonarow GC. Beta-blocker therapy for heart failure: the standard of care. Rev Cardiovasc Med. 2002; 3 (1): 14-21. (Pubitemid 34269487)
10. Metra M, Nodari S, Bordonali T, Milani P, Lombardi C, Bugatti S, et al. Bisoprolol in the treatment of chronic heart failure: from pathophysiology to clinical pharmacology and trial results. Ther Clin Risk Manag. 2007; 3 (4): 569-78.
11. Pereira MG, Ferreira JC, Bueno CR Jr, Mattos KC, Rosa KT, Irigoyen MC, et al. Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice. Eur J Appl Physiol. 2009; 105 (6): 843-50.
12. Brum PC, Kosek J, Patterson A, Bernstein D, Kobilka B. Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. Am J Physiol Heart Circ Physiol. 2002; 283 (5): H1838-45.
13. Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, et al. Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice. J Appl Physiol. 2008; 104 (1): 103-9.
14. Stickland MK, Miller JD. The best medicine: exercise training normalizes chemosensitivity and sympathoexcitation in heart failure. J Appl Physiol. 2008; 105 (3): 779-81.
15. De Matos LD, Gardenghi G, Rondon MU, Soufen HN, Tirone AP, Barretto AC, et al. Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients. J Card Fail. 2004;10 (6): 496-502.
16. Fraga R, Franco FG, Roveda F, de Matos LN, Braga AM, Rondon MU, et al. Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol. Eur J Heart Fail. 2007; 9 (6-7): 630-6.
17. Ferreira JC, Bacurau AV, Evangelista FS, Coelho MA, Oliveira EM, Casarini DE, et al. The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice. Am J Physiol Regul Integr Comp Physiol. 2008; 294 (1): R26-32.
18. Davies MF, Tsui JY, Flannery JA, Li X, DeLorey TM, Hoffman BB. Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory. Brain Res. 2003;986 (1-2): 157-65.
19. Kurnik D, Muszkat M, Friedman EA, Sofowora GG, Diedrich A, Xie HG, et al. Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects. J Hypertens. 2007; 25 (4): 763-71.
20. Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY, et al. Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. J Mol Cell Cardiol. 2008; 45 (2): 240-9.
21. Medeiros A, Vanzelli AS, Rosa KT, Irigoyen MC, Brum PC. Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure. Braz J Med Biol Res. 2008; 41 (9): 812-7.
22. Ferreira JC, Rolim NP, Bartholomeu JB, Gobatto CA, Kokubun E, Brum PC. Maximal lactate steady state in running mice: effect of exercise training. Clin Exp Pharmacol Physiol. 2007; 34 (8): 760-5. (Pubitemid 47013489)
23. Rolim NP, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, et al. Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure. Physiol Genomics. 2007; 29 (3): 246-52.
24. Xu R, Lin F, Zhang S, Chen X, Hu S, Zheng Z. Signal pathways involved in reverse remodeling of the hypertrophic rat heart after pressure unloading. Int J Cardiol. 2009. [Epub ahead of print].
25. Pina IL, Daoud S. Exercise and heart failure. Minerva Cardioangiol. 2004; 52 (6): 537-46.
26. Bacurau AV, Jardim MA, Ferreira JC, Bechara LR, Bueno CR Jr, Alba-Loureiro TC, et al. Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training. J Appl Physiol. 2009; 106 (5): 1631-40.
27. Al-Nasser F, Yousufuddin M, Al-Nozha F, Anker SD, Coats AJ, Piepoli MF, et al. Effect of carvedilol on exercise tolerance in patients with chronic heart failure and a restrictive left ventricular filling pattern. Am J Cardiol. 2003; 91 (10): 1281-3.
28. Gullestad L, Dolva LO, Soyland E, Kjekshus J. Difference between beta-1-selective and non-selective beta-blockade during continuous and intermittent exercise. Clin Physiol. 1988; 8 (5): 487-99.
29. Experience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance. European Heart Failure Training Group. Eur Heart J. 1998; 19 (3): 466-75.
30. Tyni-Lenne R, Gordon A, Europe E, Jansson E, Sylven C. Exercise-based rehabilitation improves skeletal muscle capacity, exercise tolerance, and quality of life in both women and men with chronic heart failure. J Card Fail. 1998; 4 (1): 9-17. (Pubitemid 28252536)
31. Barretto AC, Santos AC, Munhoz R, Rondon MU, Franco FG, Trombetta IC, et al. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol. 2009; 135 (3): 302-7.
32. Dyer AR, Persky V, Stamler J, Paul O, Shekelle RB, Berkson DM, et al. Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am J Epidemiol. 1980; 112 (6): 736-49.
33. Kannel WB, Kannel C, Paffenbarger RS Jr, Cupples LA. Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J. 1987; 113 (6): 1489-94.
34. Oliveira RS, Ferreira JC, Gomes ER, Paixao NA, Rolim NP, Medeiros A, et al. Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. J Physiol. 2009; 587 (Pt 15): 3899-910.
35. Kemi OJ, Ceci M, Wisloff U, Grimaldi S, Gallo P, Smith GL, et al. Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol. 2008; 214 (2): 316-21.
36. Meris A, Amigoni M, Uno H, Thune JJ, Verma A, Kober L, et al. Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo study. Eur Heart J. 2009; 30 (1): 56-65.
37. Udelson JE, Konstam MA. Relation between left ventricular remodeling and clinical outcomes in heart failure patients with left ventricular systolic dysfunction. J Card Fail. 2002; 8 (6 Suppl): S465-71.
38. Yu CM, Bleeker GB, Fung JW, Schalij MJ, Zhang Q, van der Wall EE, et al. Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy. Circulation. 2005; 112 (11): 1580-6.
39. Garciarena CD, Pinilla OA, Nolly MB, Laguens RP, Escudero EM, Cingolani HE, et al. Endurance training in the spontaneously hypertensive rat: conversion of pathological into physiological cardiac hypertrophy. Hypertension. 2009; 53 (4): 708-14.
40. Xu X, Wan W, Powers AS, Li J, Ji LL, Lao S, et al. Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats. J Mol Cell Cardiol. 2008; 44 (1): 114-22.