Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol

European Journal of Heart Failure

Volumn 9, Issue 6-7, 2007, Pages 630-636

  Fraga, Raffael ^a   Franco, Fábio G ^a   Roveda, Fabiana ^c   de Matos, Luciana N J ^a   Braga, Ana M F W ^a   Rondon, Maria U P B ^a   Rotta, Daniel R ^a   Brum, Patricia C ^a   Barretto, Antonio C P ^a   Middlekauff, Holly R ^b   Negrão, Carlos E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Cardiology ^*

Author keywords

Autonomic control; Carvedilol; Exercise; Heart failure

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; SPIRONOLACTONE;

ADULT; AGED; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; EXERCISE; HEART FAILURE; HUMAN; LUNG VENTILATION; MUSCLE FUNCTION; NERVE CONDUCTION; PLETHYSMOGRAPHY; PRIORITY JOURNAL; TRAINING; VEIN OCCLUSION;

EID: 34248170301     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2007.03.003     Document Type: Article

References (54)

1. Doughty R.N., Rodgers A., Sharpe N., and Macmahon S. Effects of beta-blocker therapy on mortality in patients with heart failure. A systematic overview of randomized controlled trials. Eur Heart J 18 (1997) 560-565
2. Yan A., Yan R., and Liu P. Narrative review: pharmacotherapy for chronic heart failure: evidence from recent clinical trials. Ann Intern Med 142 (2005) 132-145
3. Lechat P., Packer M., Chalon S., Chucherat M., Arab T., and Boissel J.P. Clinical double-blind, placebo-effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of controlled, randomized trials. Circulation 98 (1998) 1184-1190
4. Matos L.D., Garddenghi G., Rondon M.U.P.B., Soufen H.N., and Negrão C.E. Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients. J Card Fail 10 (2004) 496-502
5. Azevedo E.R., Kubo T., Mak S., et al. Nonselective versus selective beta-adrenergic receptor blockade in congestive heart failure: differential effects on sympathetic activity. Circulation 104 (2001) 2194-2199
6. Coats A.J.S., Adamopoulos S., and Radaelli A. Controlled trial of physical training in chronic heart failure: exercise performance, hemodynamics, ventilation, and autonomic function. Circulation 85 (1992) 2119-2123
7. Belardinelli R., Georgiou D., Cianci G., and Purcano A. Randomized, controlled trial of long term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 99 (1999) 1173-1182
8. Piepoli M.F., Davos C., Francis D.P., and Coats A.J. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH Collaborative). BMJ 328 (2004) 189-192
9. Roveda F., Middlekauff H.R., Rondon M.U.P.B., et al. The effects of exercise training on sympathetic neural activation in advanced heart failure. J Am Coll Cardiol 42 (2003) 854-860
10. Adamopoulos S., Ponikowski P., and Cerquetani E. Circadian pattern of heart rate variability in chronic heart failure patients. Effects of physical training. Eur Heart J 16 (1995) 1380-1386
11. Kiilavuori K., Toivonen L., Naveri H., and Leinone H. Reversal of autonomic derangements by physical training in chronic heart failure assessed by heart rate variability. Eur Heart J 16 (1995) 490-495
12. Demopoulos L., Yeh M., Gentilucci M., et al. Nonselective β-adrenergic blockade with carvedilol does not hinder the benefits of exercise training in patients with congestive heart failure. Circulation 95 (1997) 1764-1767
13. Delius W., Hagbarth K.E., Hongell A., and Wallin B.G. Manoeuvres affecting sympathetic outflow in human muscle nerves. Acta Physiol Scand 84 (1972) 82-94
14. Vallbo A.B., Hagbarth K.E., Torebjork H.E., and Wallin B.G. Somatosensory, proprioceptive and sympathetic activity in human peripheral nerves. Physiol Rev 59 (1979) 919-957
15. Fagius J., and Wallin B.G. Long-term variability and reproducibility of human muscle nerve activity at rest, as reassessed after a decade. Clin Auton Res 3 (1993) 201-205
16. Cohen-Solal A. Cardiopulmonary exercise testing in chronic heart failure. In: Wasserman K. (Ed). Exercise gas exchange in heart disease (1996), Futura Publishing Company, New York 17-38
17. Beaver W.L., Wasserman K., and Whipp B.J. A new method for detecting the anaerobic threshold by gas exchange. J Appl Physiol 60 (1986) 2020-2027
18. Wasserman K., Whipp B.J., Koyal S.N., and Beaver W.L. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 33 (1973) 236-243
19. Wasserman K., Hansen J.E., Sue D.Y., and Whipp B.J. Measurement of the physiological response to exercise. In: Wasserman K., Hansen J.E., Sue D.Y., and Whipp B.J. (Eds). Principles of exercise testing and interpretation (1987), Lea & Febiger, Philadelphia 27-46
20. Guazzi M., Reina G., Tumminello G., and Guazzi M.D. Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure. J Appl Physiol 97 (2004) 1866-1873
21. Sahn D.J., De Maria A., Kisslo J., et al. Recommendations regarding quantitation in M-mode echocardiography. Results of a survey of echocardiographic measurements. Circulation 58 (1978) 1072-1083
22. Henry W.L., De Maria A., Gramiak R., et al. Report of the American Society of Echocardiography Committee on nomenclature and standards in 2-D echocardiography. Circulation 62 (1980) 212-217
23. Schiller N.B., Shah P.M., Crawford M., et al. Recommendations for quantification of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 2 (1989) 358-367
24. Cohn J.N., Levine B., and Olivari M.T. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 31 (1984) 819-823
25. Santos A.C., Munhoz R.T., Rondon M.P.U., et al. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Circulation 110 (2004) 84 [Abstract]
26. Cleland J.G., Huan Loh P., Freemantle N., Clark A.L., and Coletta A.P. Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trial. Eur J Heart Fail 6 (2004) 787-791
27. Liu J.L., Irvine S., Reid I.A., Patel K.P., and Zucker I.H. Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure. Circulation 102 (2000) 1854-1862
28. Pliquett R.U., Cornish K.G., Patel K.P., Schulz J.D., Peuler J.D., and Zucker I.H. Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short term exercise training in male rabbits with heart failure. J Appl Physiol 95 (2003) 1883-1888
29. Zucker I.H., Patel K.P., Li S.Y.F., Wang W., and Pliquett R.U. Exercise training and sympathetic regulation in experimental heart failure. Exerc Sport Sci Rev 32 (2004) 107-111
30. Floras J.S. Sympathetic activation in human heart failure: diverse mechanisms, therapeutic opportunities. Acta Physiol Scand 107 (2003) 391-398
31. Bristow M.R., Roden R.L., Lowes B.D., Gilbert E.M., and Eichhorn E.J. The role of third generation β-blocking agents in chronic heart failure. Clin Cardiol 2 (1998) I-3-I-13
32. Cohn J.N., Fowler M.B., Bristow M.R., et al. Safety and efficacy of carvedilol in severe heart failure. J Card Fail 3 (1997) 173-179
33. Frishman W.H. Carvedilol. N Engl J Med 339 (1998) 1759-1765
34. Dunn C.J., Lea A.P., and Wagstaff A.J. Carvedilol: a reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs 54 (1997) 161-185
35. Vanhees L., Fagard R., and Amery A. Effect of verapamil on systemic and brachial artery hemodynamics in normal humans: comparison with effect of atenolol. J Cardiovasc Pharmacol 14 (1989) 642-647
36. Vanhees L., Hespel P., Hoof V., Fogard R., and Amery A. Effect of physical training on systemic and brachial artery haemodynamics in normal men. Int J Sports Med 13 (1992) 145-151
37. Linke A., Schoene N., Gielen S., et al. Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. J Am Coll Cardiol 37 (2001) 392-397
38. Katz S.D., Yuen J., Bijou R., and LeJemtel T.H. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J Appl Physiol 82 (1997) 1488-1492
39. Katz S.D., Krum H., Khan T., and Knecht M. Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure: role of endothelium-derived nitric oxide. J Am Coll Cardiol 28 (1996) 585-590
40. Hambrechet R., Fiehn E., Weigl C., et al. Regular exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98 (1998) 2709-2715
41. Sable D., Gerber J., Horwitz L., et al. Attenuation of exercise conditioning by β-adrenergic blockade. Circulation 65 (1982) 679-684
42. Marsh R., Brammell H., and Horwitz L. Attenuation of exercise conditioning by low dose beta-adrenergic receptor blockade. J Am Coll Cardiol 2 (1983) 551-556
43. Wolfel E., Hiatt R., Brammell L., et al. Effects of selective and nonselective β-adrenergic blockade on mechanisms of exercise conditioning. Circulation 74 (1986) 664-674
44. Gielen S., Adams V., Mobius-Winkler S., et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 42 (2003) 861-868
45. Gielen S., Adams V., Linke A., et al. Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil 12 (2005) 393-400
46. Adamopoulos S., Parissis J., Kroupis C., et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 22 (2001) 791-797
47. Minotti J.R., and Massie B.M. Exercise training in heart failure patients: does reversing the peripheral abnormalities protect the heart?. Circulation 85 (1992) 2323-2325
48. Mancini D.M., Davis L., Wexler J.P., Chadwick B., and LeJemtel T.H. Dependence of enhanced maximal exercise performance on increased peak skeletal muscle perfusion during long-term captopril therapy in heart failure. J Am Coll Cardiol 10 (1987) 845-850
49. Jondeau G., Katz S.D., Zohman L., et al. Active skeletal muscle mass and cardiopulmonary reserve: failure to attain peak aerobic capacity during maximal bicycle exercise in patients with severe congestive heart failure. Circulation 86 (1992) 1351-1356
50. Kleber F.X., Vietzke G., Wernecke K.D., et al. Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 101 (2000) 2803-2809
51. Piepoli M., Clark A.L., and Volterrani M. Contribution of muscle afferent to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 93 (1996) 940-952
52. Forjaz C.L., Matsudaira Y., Rodrigues F.B., Nunes N., and Negrão C.E. Post-exercise changes in blood pressure, heart rate and rate pressure product at different exercise intensities in normotensive humans. Braz J Med Biol Res 31 (1998) 1247-1255
53. Watanabe J., Thamilarasan M., Blackstone E.H., et al. Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as a predictors of mortality: the case of stress echocardiography. Circulation 104 (2001) 1911-1916
54. Bilsel T., Terzi S., Akbult T., et al. Abnormal heart rate recovery immediately after cardiopulmonary exercise testing in heart failure patients. Int Heart J 47 (2006) 431-440