Diagnostic strategy for hematology and oncology patients with acute respiratory failure: Randomized controlled trial

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 8, 2010, Pages 1038-1046

  Azoulay, Élie ^a   Mokart, Djamel ^b   Lambert, Jérôme ^a   Lemiale, Virginie ^c   Rabbat, Antoine ^d   Kouatchet, Achille ^e   Vincent, Francxois ^f   Gruson, Didier ^g   Bruneel, Fabrice ^h   Epinette Branche, Géraldine ^a   Lafabrie, Ariane ^a   Hamidfar Roy, Rebecca ⁱ   Cracco, Christophe ^j   Renard, Benoît ^k   Tonnelier, Jean Marie ^l   Blot, François ^m   Chevret, Sylvie ^a   Schlemmer, Benoît ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c Paoli Calmette Institute ^*  (France)

^d HÔTEL DIEU   (France)

^e ANGERS UNIVERSITY HOSPITAL   (France)

^f AVICENNE HOSPITAL   (France)

^g HÔPITAL PELLEGRIN   (France)

^h Mignot Hospital   (France)

ⁱ Michallon Teaching Hospital   (France)

^j PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^k Regional Hospital Center   (France)

^l BREST UNIVERSITY HOSPITAL   (France)

^m INSTITUT GUSTAVE ROUSSY   (France)

more..

Author keywords

Bone marrow transplantation; Nasopharyngeal aspirates; Neutropenia; Pneumocystis jiroveci pneumonia; Polymerase chain reaction

Indexed keywords

ACUTE RESPIRATORY FAILURE; ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CANCER PATIENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; ENDOTRACHEAL INTUBATION; FEMALE; FIBEROPTIC BRONCHOSCOPY; HUMAN; INTENSIVE CARE UNIT; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE;

ACUTE DISEASE; AGED; ANOXIA; BRONCHOALVEOLAR LAVAGE; BRONCHOSCOPY; DIAGNOSTIC TECHNIQUES, RESPIRATORY SYSTEM; FEMALE; FIBER OPTIC TECHNOLOGY; HUMANS; INTENSIVE CARE UNITS; INTENTION TO TREAT ANALYSIS; LOGISTIC MODELS; MALE; MIDDLE AGED; NEOPLASMS; RESPIRATORY INSUFFICIENCY;

EID: 78049345078     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201001-0018OC     Document Type: Article

References (47)

1. Coleman MP, Quaresma M, Berrino F, Lutz JM, De Angelis R, Capocaccia R, Baili P, Rachet B, Gatta G, Hakulinen T, et al. Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol 2008;9:730-756.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics, 2008. CA Cancer J Clin 2008;58:71-96.
3. Kinsey T, Jemal A, Liff J, Ward E, Thun M. Secular trends in mortality from common cancers in the United States by educational attainment, 1993-2001. J Natl Cancer Inst 2008;100:1003-1012.
4. Barlogie B, Tricot G, Anaissie E, Shaughnessy J, Rasmussen E, van Rhee F, Fassas A, Zangari M, Hollmig K, Pineda-Roman M, et al. Thalidomide and hematopoietic-cell transplantation for multiple myeloma. N Engl J Med 2006;354:1021-1030.
5. O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004. (Pubitemid 36302244)
6. Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005;23:8093-8108.
7. Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C, Bleickardt E, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006;354:2531-2541. (Pubitemid 43882349)
8. Pfreundschuh M, Trumper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006;7:379-391.
9. Brenner H, Gondos A, Arndt V. Recent major progress in long-term cancer patient survival disclosed by modeled period analysis. J Clin Oncol 2007;25:3274-3280.
10. Azoulay E, Thiery G, Chevret S, Moreau D, Darmon M, Bergeron A, Yang K, Meignin V, Ciroldi M, Le Gall JR, et al. The prognosis of acute respiratory failure in critically ill cancer patients. Medicine (Baltimore) 2004;83:360-370.
11. Chaoui D, Legrand O, Roche N, Cornet M, Lefebvre A, Peffault de Latour R, Sanhes L, Huchon G, Marie JP, Rabbat A. Incidence and prognostic value of respiratory events in acute leukemia. Leukemia 2004;18:670-675.
12. Azoulay E, Mokart D, Rabbat A, Pene F, Kouatchet A, Bruneel F, Vincent F, Hamidfar R, Moreau D, Mohammedi I, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data. Crit Care Med 2008;36:100-107.
13. Azoulay E, Schlemmer B. Diagnostic strategy in cancer patients with acute respiratory failure. Intensive Care Med 2006;32:808-822. (Pubitemid 43781361)
14. Hilbert G, Gruson D, Vargas F, Valentino R, Gbikpi-Benissan G, Dupon M, Reiffers J, Cardinaud JP. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001;344:481-487.
15. Lecuyer L, Chevret S, Thiery G, Darmon M, Schlemmer B, Azoulay E. The ICU trial: a new admission policy for cancer patients requiring mechanical ventilation. Crit Care Med 2007;35:808-814.
16. Gibson PG, Breit SN, Bryant DH. Hypoxia during bronchoalveolar lavage. Aust N Z J Med 1990;20:39-43.
17. Hertz MI, Woodward ME, Gross CR, Swart M, Marcy TW, Bitterman PB. Safety of bronchoalveolar lavage in the critically ill, mechanically ventilated patient. Crit Care Med 1991;19:1526-1532.
18. Davies L, Mister R, Spence DP, Calverley PM, Earis JE, Pearson MG. Cardiovascular consequences of fibreoptic bronchoscopy. Eur Respir J 1997;10:695-698.
19. Bauer TT, Torres A, Ewig S, Hernandez C, Sanchez-Nieto JM, Xaubet A, Agusti C, Rodriguez-Roisin R. Effects of bronchoalveolar lavage volume on arterial oxygenation in mechanically ventilated patients with pneumonia. Intensive Care Med 2001;27:384-393.
20. Verra F, Hmouda H, Rauss A, Lebargy F, Cordonnier C, Bignon J, Lemaire F, Brochard L. Bronchoalveolar lavage in immunocompromised patients. Clinical and functional consequences. Chest 1992;101:1215-1220.
21. British Thoracic Society guidelines on diagnostic flexible bronchoscopy. Thorax 2001;56:i1-i21.
22. Dunagan DP, Baker AM, Hurd DD, Haponik EF. Bronchoscopic evaluation of pulmonary infiltrates following bone marrow transplantation. Chest 1997;111:135-141.
23. White P, Bonacum JT, Miller CB. Utility of fiberoptic bronchoscopy in bone marrow transplant patients. Bone Marrow Transplant 1997;20:681-687.
24. Murray PV, O'Brien ME, Padhani AR, Powles R, Cunningham D, Jeanes A, Ashley S. Use of first line bronchoalveolar lavage in the immunosuppressed oncology patient. Bone Marrow Transplant 2001;27:967-971.
25. Danes C, Gonzalez-Martin J, Pumarola T, Rano A, Benito N, Torres A, Moreno A, Rovira M, Puig de la Bellacasa J. Pulmonary infiltrates in immunosuppressed patients: analysis of a diagnostic protocol. J Clin Microbiol 2002;40:2134-2140.
26. Kovacs JA, Gill VJ, Meshnick S, Masur H. New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia. JAMA 2001;286:2450-2460.
27. Martino R, Ramila E, Rabella N, Munoz JM, Peyret M, Portos JM, Laborda R, Sierra J. Respiratory virus infections in adults with hematologic malignancies: a prospective study. Clin Infect Dis 2003;36:1-8.
28. Schvoerer E, Henriot S, Zachary P, Freitag R, Fuchs A, Fritsch S, Risch S, Meyer N, Caillard S, Lioure B, et al. Monitoring low cytomegalovirus viremia in transplanted patients by a real-time PCR on plasma. J Med Virol 2005;76:76-81.
29. Maertens J, Van Eldere J, Verhaegen J, Verbeken E, Verschakelen J, Boogaerts M. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. J Infect Dis 2002;186:1297-1306.
30. Roson B, Fernandez-Sabe N, Carratala J, Verdaguer R, Dorca J, Manresa F, Gudiol F. Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia. Clin Infect Dis 2004;38:222-226.
31. Azoulay E, Mokart D, Lemiale V, Rabbat A, Kouatchet A, Vincent F, Gruson D, Bruneel F, Hamidfar R, Cracco C, et al. Diagnostic strategies in cancer patients with acute respiratory failure: a multicentre randomized controlled trial. Am J Respir Crit Care Med 2009;179:A1560.
32. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613-619.
33. Le Gall JR, Klar J, Lemeshow S, Saulnier F, Alberti C, Artigas A, Teres D. The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA 1996;276:802-810.
34. Azoulay E, Parrot A, Flahault A, Cesari D, Lecomte I, Roux P, Saidi F, Fartoukh M, Bernaudin JF, Cadranel J, et al. AIDS-related Pneumocystis carinii pneumonia in the era of adjunctive steroids: implication of BAL neutrophilia. Am J Respir Crit Care Med 1999;160:493-499.
35. Azoulay E, Fieux F, Moreau D, Thiery G, Rousselot P, Parrot A, Le Gall JR, Dombret H, Schlemmer B. Acute monocytic leukemia presenting as acute respiratory failure. Am J Respir Crit Care Med 2003;167:1329-1333. (Pubitemid 36609715)
36. Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, Crokaert F, Denning DW, Donnelly JP, Edwards JE, Erjavec Z, et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002;34:7-14.
37. Azoulay E, Mayaud C. Candida pneumopathy: fact or fiction? Rev Pneumol Clin 1999;55:349-351.
38. Gentile G, Donati PP, Capobianchi A, Rolli M, Iori AP, Martino P. Evaluation of a score system for the severity and outcome of cytomegalovirus interstitial pneumonia in allogeneic bone marrow recipients. J Infect 1997;35:117-123.
39. Kress JP, Christenson J, Pohlman AS, Linkin DR, Hall JB. Outcomes of critically ill cancer patients in a university hospital setting. Am J Respir Crit Care Med 1999;160:1957-1961.
40. Gruson D, Hilbert G, Valentino R, Vargas F, Chene G, Bebear C, Allery A, Pigneux A, Gbikpi-Benissan G, Cardinaud JP. Utility of fiberoptic bronchoscopy in neutropenic patients admitted to the intensive care unit with pulmonary infiltrates. Crit Care Med 2000;28:2224-2230.
41. Rano A, Agusti C, Jimenez P, Angrill J, Benito N, Danes C, Gonzalez J, Rovira M, Pumarola T, Moreno A, et al. Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures. Thorax 2001;56:379-387.
42. Rabbat A, Chaoui D, Lefebvre A, Roche N, Legrand O, Lorut C, Rio B, Marie JP, Huchon G. Is BAL useful in patients with acute myeloid leukemia admitted in ICU for severe respiratory complications? Leukemia 2008;22:1361-1367.
43. Antonelli M, Conti G, Riccioni L, Meduri GU. Noninvasive positive-pressure ventilation via face mask during bronchoscopy with BAL in high-risk hypoxemic patients. Chest 1996;110:724-728.
44. Maitre B, Jaber S, Maggiore SM, Bergot E, Richard JC, Bakthiari H, Housset B, Boussignac G, Brochard L. Continuous positive airway pressure during fiberoptic bronchoscopy in hypoxemic patients. A randomized double-blind study using a new device. Am J Respir Crit Care Med 2000;162:1063-1067.
45. Peikert T, Rana S, Edell ES. Safety, diagnostic yield, and therapeutic implications of flexible bronchoscopy in patients with febrile neutropenia and pulmonary infiltrates. Mayo Clin Proc 2005;80:1414-1420.
46. Rolston KV, Bodey GP, Safdar A. Polymicrobial infection in patients with cancer: an underappreciated and underreported entity. Clin Infect Dis 2007;45:228-233.
47. Walsh FW, Rolfe MW, Rumbak MJ. The initial pulmonary evaluation of the immunocompromised patient. Chest Surg Clin N Am 1999;9:19-38.