Enhancement of DC vaccine potency by activating the PI3K/AKT pathway with a small interfering RNA targeting PTEN

Immunology Letters

Volumn 134, Issue 1, 2010, Pages 47-54

  Kim, Jin Hee ^a   Kang, Tae Heung ^a   Noh, Kyung Hee ^a   Kim, Seok Ho ^a   Lee, Young Ho ^a   Kim, Keon Woo ^a   Bae, Hyun Cheol ^a   Ahn, Ye Hyeon ^a   Choi, Eun Young ^b   Kim, Jin Seok ^c   Lee, Kyung Mi ^a   Kim, Tae Woo ^a,c  

^a Korea University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Sookmyung Women's University   (South Korea)

Author keywords

AKT; Dendritic cell; Immunotherapy; PI3K; PTEN; SiRNA

Indexed keywords

CASPASE 3; CHEMOKINE RECEPTOR CCR7; DENDRITIC CELL VACCINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CANCER IMMUNIZATION; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL MEDIATED CYTOTOXICITY; CELL MIGRATION; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; DRUG POTENCY; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE TECHNOLOGY; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; INTERFERON PRODUCTION; LYMPH NODE; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; TUMOR VOLUME; UPREGULATION;

ANIMALS; BCL-X PROTEIN; BLOTTING, WESTERN; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; LYMPH NODES; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PTEN PHOSPHOHYDROLASE; RECEPTORS, CCR7; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78049306941     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.08.008     Document Type: Article

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